Posted by admin on Aug 1, 2012 in |
Objectives: The study was designed to evaluate hepatoprotective effect of the ethanolic leaves extract of Jasminum grandiflorum (JG) in Isoniazid (INH) induced hepatotoxicity in wistar albino rats. Materials and methods: Mature leaves of JG were collected, authenticated and subjected to successive ethanolic extraction. Hepatic damage was induced in wistar rats by administering INH (54mg/kg, p.o.) once a daily for 30 days followed by administration of JG(200mg/kg, p.o.) 1h.prior to the administration of INH (54mg/kg, p.o.) once daily. Silymarin (50mg/kg. p. o) was used as standard for 30 days. Result: Elevated levels of Aspartate transaminase, Alanine transaminase, and Lipid profile following INH administration were significantly lowered by JGtreatment. Deposition of collagen was observed in liver and found to be less inJG treated animals; Pretreatment of rats with JG significantly decreases Lipid peroxidation (LPO) and increases the antioxidant activities. Conclusion: The study reveals the hepatoprotective activity of leaves extract of JGin isoniazid induced liver...
Read More
Posted by admin on Aug 1, 2012 in |
The objective of the present study was to evaluate the anticataleptic effect of Halela siyah (Terminalia chebula Retz) extract, on haloperidol induced catalepsy in swiss mice which were divided into four groups of six animals each. Animals in different groups were administered distilled water, scopolamine (1.0 mg/kg p.o) and hydroxy alcoholic (3:7) extract of Halela siyah (Terminalia chebula Retz), 1.5gm/kg and 3gm/kg p.o. respectively. Catalepsy was induced with haloperidol (1.0 mg/kg i.p.) administered 30 minutes prior to the drug administration. The duration of cataleptic time in the animals was assessed at 30 minute intervals up to 120 minutes and at the end of 240 minutes. Haloperidol induced catalepsy test was carried out for single dose study and after seven days of drug administration, to assess time and dose dependent effect of the test drug. The results showed that after the haloperidol administration, Halela siyah (Terminalia chebula Retz) extract in different doses was effective in reducing the cataleptic time significantly (p<0.01) in a time and dose dependent manner. The present...
Read More
Posted by admin on Aug 1, 2012 in |
In the present study, ethanolic nanovesicles of Aceclofenac developed for the site specific delivery to joints for effective treatment of osteoarthritis. Ethanolic nano-vesicles were prepared by solvent dispersion method. Vesicles were characterized for vesicular size, surface morphology, size and size distribution, zeta potential, entrapment efficiency. Formulations were also evaluated for drug-vesicle (excipients) interaction, in vitro permeation, in vitro deposition. The TEM showed dark vesicular structures by which it is possible to notice the outer most bilayer. In the ethanol concentration range of 20-40%, the size of the vesicles increased with decreasing ethanol concentration, with the largest vesicles in preparations containing 20% ethanol (809.34±2.329 nm) and the smallest in preparations containing 40% ethanol (627±3.684 nm). Zeta potential of formulations shows negative value, which indicates that, the higher concentration of ethanol make the negative charge on vesicles surface. The entrapment was found to increase with increase in ethanol concentration, however percent entrapment decreased when ethanol concentration exceeded 40%. The FTIR spectra reveled no considerable change in IR peaks of Aceclofenac loaded...
Read More
Posted by admin on Aug 1, 2012 in |
India is a landmark for traditional system of medicine from past few centuries. Most of the medicines are effective but only one major drawback is lack of standardization. So, there is a need to develop a standardization technique to mingle this system of medicine in the main stream of health science. Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles. The present work is an attempt to standardize Vatari Churna, a traditional formulation, used in rheumatoid arthritis. Marketed and in-house preparation was used for the study. The various parameters performed included organoleptic characteristics, physical characteristics physicochemical. The results obtained may be considered as tools for assistance to the regulatory authorities, scientific organizations and manufacturers for developing standard formulation of great...
Read More
Posted by admin on Aug 1, 2012 in |
Antioxidant property of Phomopsis amygdali culture filtrate extracted with ethanol, was evaluated in vitro. ABTS and DPPH radicals were used to evaluate their antioxidant activity. Antioxidant components like total phenol and flavonoid were also determined. The ethanolic extract of Phomopsis amygdali showed potent antioxidant activity against both ABTS and DPPH radicals with the EC50 value of 580.02 ± 0.511μg/ml and 2030.25±501 μg/ml respectively. Total amount of phenol and flavonoid quantified were of 18.33 ± 0.68 gallic acid equivalents per gram and 6.44 ± 1.24 μg/mg of quercetin equivalent respectively. In conclusion, the culture filtrate of Phomopsis amygdali may have potential source of natural...
Read More
