Posted by admin on Jun 1, 2012 in |
Nalbari district is situated in between 26°N and 27oN latitude and 92oE and 97oE longitude. It lies between Kamrup and Barpeta district of lower Assam. Nalbari has a population of 1138184 (2001 census). An ethnobotanical Survey was conducted in 2010 in selected villages to explore the medicinal plant used by the villagers to cure Diabetes. This villages are inhabited by Boros, Koch, Muslim communities. The indigenous knowledge of local traditional healers and native plants used by the villagers to cure Diabetes were collected using a questionnaire and personal interviews. Total 30 villagers in the age group of 30-68 years were interviewed out of which 3 were local healers. The investigation reveals 35 species of plants belonging to 28 families which are used to cure Diabetes. It is found that the whole plant is used for curing the ailment but mostly fresh juice, powder, fresh leaves, paste or decoction in water remains the most preferred method of preparation. Most plants are very effective remedy when used in a combination or...
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Posted by admin on Jun 1, 2012 in |
Objective: Analysis of prescribing pattern of antihypertensives in patients with hypertension alone and with coexisting diabetes mellitus. Materials and Methods: A cross sectional study was conducted in an outpatient and inpatient department of general medicine at JJM Medical College hospital for a period of 3 months (July 2011 to September 2011). Prescriptions of the patients were collected and relevant data was entered in the preformed proforma and analyzed. Results: A total of 210 prescriptions were analyzed using chi square test. Out of which 126 prescriptions were of patients with hypertension alone which contain calcium channel blockers (30%), beta blockers (26%), angiotensin receptor blockers (15%), angiotensin converting enzyme inhibitors (4%) and fixed dose combinations of angiotensin receptor blockers with hydrochlorothiazide (11%) and combination of amlodipine with hydro-chlorothiazide (2.5%).84 Prescriptions of hypertension with coexisting diabetes mellitus had calcium channel blockers (24%), angiotensin converting enzyme inhibitors (19%), angiotensin receptor blockers (13%), beta blockers (13%), and fixed dose combinations of angiotensin receptor blockers with hydrochlorothiazide (18%) and combination of amlodipine with hydrochlorothiazide (6%).[χ2=17.01,...
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Posted by admin on Jun 1, 2012 in |
Phytochemical screening and antibacterial activity of aqueous and methanolic root extracts of Stachytarpheta indica Vahl. was assessed. Phytochemical analysis revealed the presence of flavonoids, terpenoides, tannins and reducing sugars. The antibacterial properties of both the aqueous and methanolic extracts were studied against clinically important bacteria viz., Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa and Enterobacter aerogens by disc diffusion method. The aqueous extract showed significant activity against all the presently investigated species of bacteria which is comparable with standard antibiotic streptomycin. At the concentrations of 50-100µg /disc, aqueous extract showed significant zone of inhibition against E. coli, (14 mm), B. cereus (13 mm), P. aeruginosa, (17 mm), and E. aerogens (7 mm). Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) have been determined. The MIC values observed was 20, 30, 5 and 25µg/ml (for aqueous extract) and 40, 35, 20 and 30µg/ml (for methanolic extract) against E. coli, B. cereus, P. aeruginosa, and E. aerogens respectively. Further isolation of active compound responsible for the activity could be the potential...
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Posted by admin on Jun 1, 2012 in |
Among the different routes of administration, the oral route of administration continues to be the most preferred route due to various advantages including ease of ingestion, avoidance of pain, versatility and most importantly patient compliance. The different dosage forms include tablets and capsules. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better patient compliance. The present work involves the formulation development, optimization and in-vitro evaluation of immediate release allylestrenol tablets. To minimize critical process parameters and since allylestrenol is heat sensitive, direct compression method was selected for the formulation of immediate release allylestrenol tablets. Tablets were prepared using cross carmellose sodium, crosspovidone, pre gelatinized starch and sodium starch glycolate as disintegrants. During the course of study it was found that the formula G4 containing sodium starch glycolate as disintegrant exhibited acceptable disintegration time, percentage drug content per tablet and in vitro drug release. So at last it was concluded that immediate release...
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Posted by admin on Jun 1, 2012 in |
A new, simple, precise, sensitive, accurate and reproducible Reverse phase HPLC method was developed and validated for the analysis of amlodipine in bulk dosage forms. The separation was conducted by using c-18 RP-HPLC coloumn, which was maintained at ambient temperature. The mobile phase consisting of Phosphate buffer and Acetonitrile (90:10v/v) was delivered at a rate of 1.5 ml/min. The analysis was detected by using UV detector at the wave length of 225nm.The method is validated for its specificity, precision, accuracy, linearity and robustness. The method was found to be linear over the concentration range 10-100 mg/ml (r2 =0.999). The retention time for amlodipine was found to be 3.34min. Limit of quantification of the method is 0.179mg/ml and limit of detection is 0.054...
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