Posted by admin on Jul 1, 2012 in |
Argemone mexicana isan indigenous herb commonly known as Prickly poppy. It belongs to the family Papaveraceae. Argemone mexicana is noted to possess medicinal benefits in traditional system of medicine. During last few decades, there has been increasing interest in the study of medicinal properties of this plant and it is reported for Antimicrobial, Antidiabetic, Antioxidant and Hepatoprotective activity. The plant was also reported for other activities like Larvicidal activity, Wound healing activity, Cancer activity, Antihelmintic activity and Neuropharmacological studies. In light of these medicinal properties, this plant can be represented as a valuable source of medicinal compound. This study depicts the overall information about the ethnobotany, phytochemistry and pharmacological activities of the A....
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Posted by admin on Jul 1, 2012 in |
Moxifloxacin Hydrochloride is a fluorinated quinolone antibacterial and Bromfenac Sodium is a non-steroidal anti-inflammatory. The combination formulation is used for the treatment of the reduction of post operative inflammatory conditions of the eye. Three new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Moxifloxacin Hydrochloride (MOX) and Bromfenac Sodium (BROM) in their combined dosage forms. Method – I is based on simultaneous equation method using two wavelengths, 294 nm (λmax of MOX) and 265 nm (λmax of BROM). Method – II Q‐absorption Ratio method using two wavelengths, 294 nm (λmax of MOX) and 276.66 nm (Isoabsorptive point). Method – III involves the use of First order derivative technique. Here 301.71 nm, the zero crossing point of Bromfenac Sodium, was selected for the determination of Moxifloxacin Hydrochloride and 293.22 nm, the zero crossing point of Moxifloxacin Hydrochloride, was selected for the determination of Bromfenac Sodium. Methanolic HCL (0.1 M) was the solvent used in all three methods. Moxifloxacin showed linearity in...
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Posted by admin on Jul 1, 2012 in |
The antifungal, antimicrobial, antioxidant and cytotoxic activities of methylene chloride, methanol and hydroethanolic extracts of the leaves of Bridelia ferruginea and sterm bark of Pteleopsis suberosa were investigated against six Gram Positive and Gram negative strains bacteria and six species of Aspergilus. The antimicrobial activity was investigatedby the microtest method using p-iodonitrotetrazolium and theantifungal activity by measuringthe mycelial and sporulation inhibition. The phytochemical study was performed on Thin Layer Chromatography and antioxidant activity was assayed using qualitative and quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging test. The methanolic extract of Pteleopsis suberosa showed better Minimum Inhibitory Concentration against all the tested bacteria. The strongest activity was observed with the methanolic extract of Pteleopsis suberosa against S. aureus meticillin resistant with Minimum Inhibitory Concentration value of 78µg/ml. All extracts showed an interesting sporulation inhibitory percentage up to 60% whereas little to moderate inhibition was obtained against mycelial development (9.18 to 57.53%). The antioxidant activity of extracts increased in dose dependent manner. The methanolic and hydroethanolic extracts were the most active with inhibitory percentage...
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Posted by admin on Jul 1, 2012 in |
Medicinal plants represent a rich source of antimicrobial agents. The traditional medicine involves the use of different plant extracts of bioactive constituents. Ficus is a huge tropical deciduous or evergreen tree with more than 800 species. Purpose: Ficus benghalensis, Ficus religiosa, Ficus recemosa are important ingredients in many siddha, ayurveda and traditional formulations and used for the treatment of bacterial infections. An attempt was made to study the antibacterial effect of Ficus sp., by appropriate methods. Method: The acetone, methanol, ethylacetate extracts of Ficus benghalensis, Ficus religiosa, Ficus recemosa were evaluated for antibacterial activity against medically important bacteria Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Bacillus subtilis, Staphylococcus aureus. Phyto constituents of three plants were screened. The in-vitro antibacterial activity was performed by agar disc diffusion assay. Results: The plant extract that showed higher active antibacterial activity against tested bacterial strain was chosen analyse beta-lactamase inhibitory activity. Ficus sp. Showed more antibacterial activity on Escherichia coli, Staphylococcus aureus and Proteus vulgaris. Conclusion: Amongst the plant species screened, Ficus benghalensis extracts...
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Posted by admin on Jul 1, 2012 in |
Drug interaction represents a major problem in day- to- day practice. The incidence of adverse reactions increases almost exponentially as the number of drugs co prescribed rises, and this is in part due to interaction. Critically ill, chronically ill and elderly patients are particularly at risk of drug interactions due to polypharmacy as well as impaired homeostatic mechanisms. The study was aimed to assess polypharmacy and drug interaction in the prescriptions. The study was carried out by taking 200 prescriptions from different departments of our hospital and assessed the drug interaction through Micromedex and Drugs update. Polypharmacy was assessed using Prescribing indicators in WHO drug use indicators. Polypharmacy was observed in 85% of the prescriptions and drug interaction was observed in 58.5% of the...
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