Posted by admin on Apr 1, 2012 in |
The aim of this research was to formulate a matrix-type transdermal therapeutic system containing drug ciprofloxacin with different ratios of hydrophobic (ethyl cellulose) polymer by solvent evaporation technique, using 15% w/w of dibutyl phthalate to the polymer weight, incorporated as plasticizer. Different concentrations of isopropyl myristate were used to enhance the transdermal permeation of Ciprofloxacin. Formulated transdermal films were physically evaluated with regard to thickness, weight variation and drug content. All prepared formulations showed good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. Formulation T3 showed best in-vitro skin permeation through goat skin as compared to all other formulations. The release profile of the optimized formulation T3 indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation T3 showed highest flux among all other formulations. These results indicate that the formulation containing highest amount of isopropyl myristate gives better penetration of ciprofloxacin through goat...
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Posted by admin on Apr 1, 2012 in |
An ethnomedicinal plant, Hugonia mystax L., was examined for preliminary phytochemical screening and antimicrobial activity. Preliminary phytochemical screening showed the presence of various classes of secondary metabolites such as flavonoids, phenols, saponins, steroids, tannins and terpenoids. Antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous fruits extracts showed significant activity against the human pathogens such as Streptococcus pneumoniae causing brain abscesses, pneumonia and septic arthritis; Proteus vulgaris, Pseudomonas aeruginosa causing urinary tract infections and septicaemia; Salmonella typhi causing typhoid fever, Vibrio species causing diarrheal infections and the fungus Candida albicans causes urinary tract infections. The antimicrobial activity of the petroleum ether, chloroform, ethanolic and aqueous fruits extracts showed concentration-dependent activity against all the tested bacteria at various concentrations. Thus, the present findings revealed the medicinal potential of H. mystax to develop a drug against various human...
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Posted by admin on Apr 1, 2012 in |
Present studies on the synthesis and evaluation of anticonvulsant activity of some 6- Substituted- 6H- Pyrrolo [3, 4-d] Pyridazine derivatives. In the preliminary screening for anticonvulsant activity in albino rats, all the synthesized compounds were found to be active, even more than standard at dose 50mg/kg body...
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Posted by admin on Apr 1, 2012 in |
This study was carried out to investigate the hepatoprotective and antioxidant properties of vimliv in ethanol-induced hepatotoxicity in rats. The liver toxicity was induced by the administration of ethanol to the animals at dose of 3 g/kg orally for 35 days. During the period of vimliv was co-administered to the rats at doses of 25 and 50 mg/kg for 35 days. The levels of lipidperoxidative products significantly increased and the levels of antioxidants decreased in ethanol induced rats. Co-administration of vimliv to ethanol-induced rats were significantly minimized the alterations in the levels of lipidperoxidation and antioxidatns. Administration of vimliv protected the liver against ethanol-induced toxicity, possibly by reducing the rate of lipidperoxidation and increasing the antioxidant defense mechanism in...
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Posted by admin on Apr 1, 2012 in |
Acute and sub-acute toxicity of ethanolic extract of Caesalpinia crista (Linn.) was evaluated in Albino mice. The acute toxicity studies were conducted as per the OECD guidelines 420, here the limit test dose of 2000mg/kg used. Observations were made and recorded after treatment at 2 hrs, 4 hrs, 8 hrs and then for seven days regularly for respiration rate, heart rate, and behavioural signs like apathy, reduced locomotor activity as well as licking. Three groups of 6 mice were made for the sub-acute toxicity study. Group I (control) received distilled water, group II 200 mg/kg and group III 400 mg/kg received ethanolic extracts every 24 hr orally for 28 days. No toxic effects of the Ethanolic extract were observed on body and organ weights between the control and the treated group after 28 days of treatment. No significant variation was found in the Hematological analysis and clinical blood chemistry. No mortality was found during...
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