Posted by admin on Apr 1, 2012 in |
The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol succinate using pH sensitive polymer HPMC and sodium alginate and to evaluate its efficacy in reducing the hypertension. The drug filler blend was mixed with various concentrations of hydrophilic polymers such as HPMC, sodium alginate and combination of both the matrixing agents. The tablets were prepared by wet granulation method. Matrix tablets were evaluated for weight variation, content uniformity, friability, hardness, thickness, swelling index, and in vitro dissolution. The assays of different formulations were determined and the drug content was found between 85-115%. The weight variation was observed to be within the prescribed limits for each formulation. In-Vitro drug release studies carried out with different formulation tablets in 0.1N HCl for 2hrs, pH 6.8 phosphate buffer for 12hrs. Up to 2 hr study the formulation shows low release in gastric medium (0.1N HCl). From the 2 hr up to 12 hr study percentage of drug release was increased in intestinal fluid (pH...
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Posted by admin on Apr 1, 2012 in |
The extracts of the prop roots of Pandanus fascicularis Lam (Family: Pandanaceae) is claimed as an antidiuretic by some traditional practitioners. However, the validity of this claim has not been scientifically proven or refuted. The aim of this study was to evaluate the antidiuretic potential of ethanol and aqueous extracts of prop roots of P. fascicularis in rats following oral administration. Ethanol and aqueous extracts were prepared from P. facicularis by percolation and cold maturation, respectively. Furosemide was used as a diuretic agent to induce diuresis. Vasopressin (ADH) was used as a standard. The results demonstrated both the ethanol and aqueous extracts of P. facicularis and ADH significantly impaired the total urine output. However, antidiuretic potential of ethanolic extract was similar to that of ADH. The extracts caused a significant decrease in natriuresis and kaliuresis. From this study, we can conclude that ethanol extract of prop roots of Pandanus fascicularis has beneficial effects on anti diuretic activity. It has the potential to impart therapeutic effect in...
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Posted by admin on Apr 1, 2012 in |
BACKGROUND: Self-medication is the selection and use of medicines by individuals to treat selfrecognised illnesses or symptoms and an important initial response to illnesses if successfully used. The objective of this study was to assess knowledge, attitude and practice of self medication among Medical Sciences Faculty students of Jimma University. METHODS: A cross sectional study was conducted in Medical sciences Faculty students in 2009.The faculty and the three schools were selected by lottery method .Then, within the faculty respective number of students for each School was determined by proportion from the total sample size. Data was collected randomly from each School using self administered questionnaires and analyzed using SPSS version 16.0 RESULTS: From a total of 403 (100%) participants,95 (45.89%) students practiced self medication in the past two months for commonly perceived illnesses such as headache 35 (36.85%), abdominal pain 29 (30.55%) and cough 33 (23.16%) using mainly analgesics 40(49.38%) and antibiotics 29 (35.80%) mostly from drug retail outlets 88(92.63). Fifty seven (60.00%) respondents can recall the dose, frequency...
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Posted by admin on Apr 1, 2012 in |
The present study demonstrates the use of mixed co solvency in the enhancement of solubility and estimation of ketoprofen, practically water insoluble dug and thus precludes the use of organic solvents. The selected solubilizers were sodium citrate (15%), PEG 400 (8%) and polyvinyl pyrolidine (7%). Beer’s law was obeyed in the concentration range of 2-20µg/ml at wavelength of 256nm. The solubility of ketoprofen was increased by 30 folds in the mixed cos-solvents as compared to distilled water. The recovery study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method. The low values of LOD and LOQ indicated good sensitivity of proposed method. The study proved that mixed co-solvency phenomenon is an effective technique in enhancement of aqueous solubility of poorly water soluble drugs and can be successfully employed for estimation of drugs in routine analysis of...
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Posted by admin on Apr 1, 2012 in |
Cinnamomum tamala is found in tropical and sub-tropical Himalayas and in some other places. Phytochemical screening of the plant extracts were done to screen their active constituents. Antimicrobial activity of this plant extract was investigated by Kirby-Bayer methodology against four pathogenic organisms: K. Pneumonae, E. coli, S. aureus, and P. aeroginosa. The plant Butanol extract showed inhibitory activity against all the tested organisms and it has enhanced immunomodulatory activity also. Butanol extracts containing remarkable positive results for phytochemicals compared to other solvent extracts. The higher concentration (100mg/ml) of butanol extracts shows maximum inhibition. Proliferation and activation of lymphocytes was also identified. The study scientifically validates the use of plant in traditional medicine....
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