Posted by admin on Mar 1, 2012 in |
The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins. It also exhibited antioxidant activity by showing the increased activity of SOD, CAT, GPx and GRD and decreased in TBARS compared to CCl4 treated groups. Silymarin, a known hepatoprotective drug is used for comparison. The plant extracts were effective in protecting liver against injury induced by CCl4 in...
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Posted by admin on Mar 1, 2012 in |
Centella asiatica is a medicinal plant. It is severely affected by leaf spot disease caused by a harmful, antibiotic resistant phyto pathogen Xanthomonas campestris pv. centellae (X. c. pv. c). Farmers used synthetic pesticides to control the disease. When pesticides are applied to control this pathogen, pesticides may cause environmental hazards and health problems in man. But traditionally plants are used to prevent or control the plant diseases in agriculture. It is an eco- friendly, biocontrol, traditional method. Hence the aim of the present study is to control the pathogen in biocontrol method by screening the phytochemicals and antibacterial activity of petroleum ether, chloroform, benzene, methanol and aqueous extracts of fronds of five ferns (Pteridophytes) Adiantum caudatum, Angiopteris evecta, Pteris confusa, Pteris argyraea and Lygodium microphyllum against X. c. pv. c. The methanol extracts of all the ferns gave successful result against the tested bacteria. Phytochemical analysis of all the extracts revealed that antibacterial activity is due to the presence of alkaloids, flavonoids and phenolic compounds. According to the...
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Posted by admin on Mar 1, 2012 in |
In the present study,FDDS of Famotidine, a copmpetative inhibitor of histamine H2 receptors were prepared by using natural gums viz. xanthan gum and guar gum at different drug to gum ratio using sodium bicarbonate and citric acid as gas generating agents and lactose as diluent.FDDS tablets were prepared by wet granulation technique using PVP K30 as granulating agent. The prepared FDDS tablets were evaluated for its pre compression characteristics like bulk density, angle of repose, true density and compresibility index and post compression parameters such as hardness, friability, uniformity of drug content, in vitro floating studies, in vitro dissolution studies. The physical evaluation of all the formulations showed values within the prescribed limits for tests like hardness, friability and weight variation which indicate that the prepared tablets are of standard quality. The floating lag time of all the formulations was less than 10 minutes,All the formulations showed good matrix integrity and retarded the release of drug for 10 hours. Formulation X3 containg drug: xantahne gum ratio of 1:3 showed...
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Posted by admin on Mar 1, 2012 in |
The development of topical anesthetics can serve as a better alternative to infiltration anaesthesia for short dermatosurgical procedures. EMLA cream (eutectic mixture of local anesthetics), a topical local anesthetic cream has been shown to penetrate intact skin and provide analgesia of superficial layers. Very few comparative studies are available and therefore data regarding the efficacy and patient acceptability of EMLA over lignocaine infiltration are limited. So, with this background the present prospective study was planned to compare the efficacy, safety and patient acceptability of topical EMLA cream with lignocaine infiltration in patients undergoing radiofrequency ablation of warts from the intact skin of face and neck. A total of 40 volunteer patients with 10 – 15 warts present on face and neck were divided into two groups (group A and B), 20 patients in each group. Group A received lignocaine infiltration and group B received topical EMLA cream under occlusive dressing. The procedure was executed after 5 min of lignocaine infiltration and 30 min of EMLA application. Pain assessment was...
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Posted by admin on Mar 1, 2012 in |
Identification of protein-ligand interactionnetworks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics. In this study we have developed a novel computational strategy to identify ligand binding profiles of proteins across gene families and applied it to predicting protein functions, elucidating molecular mechanisms of drug adverse effects, and repositioning safe pharmaceuticals to treat different diseases The resultant network is then extrapolated to proteomics level to sort out the genes only expressed in the specific cancer types. The network is statistically analyzed and represented by the graphical interpretation to encounter the hub nodes. The objective of developing a biological networking is for the evaluation and validation of cancer drugs and their targets. In the field of cancer biology, the drug and their targets holds a role of paramount importance. With the work conducted here it shows the study of relation between drug target networks. Kaposi’s sarcoma (KS) is a systemic disease...
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