Posted by admin on Mar 1, 2012 in |
Protective effect of Cassia auriculata Linn., floral extract was examined against Isoproterenol induced Myocardial infarction in male albino rats. The oral administration of aqueous extract of Cassia auriculata, afforded protection against Isoproterenol induced alterations in Cholesterol, LDL, HDL, TG, Protein, AST, ALT, LDH, Catalase and GPx. The protective effect was further supported by the histological observations. The results clearly demonstrate that Cassia auriculata flowers have potent cardioprotective...
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Posted by admin on Mar 1, 2012 in |
Ondansetron is the first of a new class of drugs, selective serotonin receptor antagonist (5 hydroxy tryptamine type 3) used as an anti emetic associated with cancer chemotherapy. Its Orally Disintegrating Tablet has been developed for patients who find swallowing difficult by freeze dried technology by RP Scherer Corporation and Scherer DDS. The aim of this study was to design a new orally disintegrating tablet that has high hardness and a fast disintegration rate using conventional tablet technology. Ondansetron ODT was prepared by using traditional technology like direct compression and wet granulation technique. As blend exhibited poor flow in direct compression process, so wet granulation process was finalized. Bitter taste of Ondansetron has been masked by use of sweetener like aspartame and peppermint flavor. Quick disintegration has been achieved by use of surfactant in the granulating solvent and superdisintegrant like crospovidone in both intra and extragranular part. Design space has been created by use of different concentrations of both binders as well as disintegrant with the help of DOE...
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Posted by admin on Mar 1, 2012 in |
Cichorium intybus Linn (Compositae) contains UV-absorbing metabolites. Studies on methanol extract of Cichorium intybus Linn by means of HPLC-UV, NMR, HPLC-MS resulted in isolation and identification of three previously unknown flavones glycosides: 5, 6, 7, 3′, 4′, 7′-hexahydroxy flavones-7-O-β-D-glucopyranoside (1), 3, 5, 7 – trihydroxy-3′,4′-dimethoxy-flavone-7-O-β-D-galactopyranosyl-(1→4)-β-D-xylopyranosyl-3-O-α-L-rhamnopyranoside (2), 3, 5, 7-trihydroxy-6, 4′-dimethoxy flavones (3) also isolated were three known flavones, luteolin (4), ladanetin (5) and spicoside...
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Posted by admin on Mar 1, 2012 in |
Antibacterial and cytotoxic activities of the chloroform extract of the stem bark of Crataeva nurvala (Bengali name- Borun; Family- Capparidaceae) were studied. Antibacterial activity was determined against two Gram positive (Bacillus cereus, Bacillus megaterium,) and four Gram negative (Escherichia coli, Shigella dysenteriae, Shigella sonnei, Shigella boydii) human pathogenic bacteria by disc diffusion method. The range of zone of inhibition of the extract was 8.3 to 22.1 mm. The extract showed no activity against Bacillus megaterium. Brine shrimp lethality bioassay method was used to determine the toxicity of the plant extract and ampicillin trihydrate was used as positive control. The LC50 values of standard ampicillin trihydrate and extract were 11.48 µg/ml and 14.12 μg/ml respectively. In addition serial dilution technique was used to determine the minimum inhibitory concentration (MIC) of the plant extract. The MIC values were recorded 62.5 µg/ml against both Escherichia coli and Bacillus...
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Posted by admin on Mar 1, 2012 in |
A rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of zoledronic acid in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on an ODS C18column (250 x 4.6 mm x 5 m length),using a mixture of methanol and 0.01M phophate buffer (pH-3) (60:40 v/v) as the mobile phase at a flow rate of 0.8 mL/min and the detection was done at 210 nm. The retention time of the drug was 3.812 min. The method produced linear responses in the concentration range of 0.25 to 60 g/mL of zoledronic acid. The method was found to be reproducible for analysis of the drug in parentral...
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