Posted by admin on Apr 1, 2012 in |
The extracts of the prop roots of Pandanus fascicularis Lam (Family: Pandanaceae) is claimed as an antidiuretic by some traditional practitioners. However, the validity of this claim has not been scientifically proven or refuted. The aim of this study was to evaluate the antidiuretic potential of ethanol and aqueous extracts of prop roots of P. fascicularis in rats following oral administration. Ethanol and aqueous extracts were prepared from P. facicularis by percolation and cold maturation, respectively. Furosemide was used as a diuretic agent to induce diuresis. Vasopressin (ADH) was used as a standard. The results demonstrated both the ethanol and aqueous extracts of P. facicularis and ADH significantly impaired the total urine output. However, antidiuretic potential of ethanolic extract was similar to that of ADH. The extracts caused a significant decrease in natriuresis and kaliuresis. From this study, we can conclude that ethanol extract of prop roots of Pandanus fascicularis has beneficial effects on anti diuretic activity. It has the potential to impart therapeutic effect in...
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Posted by admin on Apr 1, 2012 in |
BACKGROUND: Self-medication is the selection and use of medicines by individuals to treat selfrecognised illnesses or symptoms and an important initial response to illnesses if successfully used. The objective of this study was to assess knowledge, attitude and practice of self medication among Medical Sciences Faculty students of Jimma University. METHODS: A cross sectional study was conducted in Medical sciences Faculty students in 2009.The faculty and the three schools were selected by lottery method .Then, within the faculty respective number of students for each School was determined by proportion from the total sample size. Data was collected randomly from each School using self administered questionnaires and analyzed using SPSS version 16.0 RESULTS: From a total of 403 (100%) participants,95 (45.89%) students practiced self medication in the past two months for commonly perceived illnesses such as headache 35 (36.85%), abdominal pain 29 (30.55%) and cough 33 (23.16%) using mainly analgesics 40(49.38%) and antibiotics 29 (35.80%) mostly from drug retail outlets 88(92.63). Fifty seven (60.00%) respondents can recall the dose, frequency...
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Posted by admin on Apr 1, 2012 in |
The present study demonstrates the use of mixed co solvency in the enhancement of solubility and estimation of ketoprofen, practically water insoluble dug and thus precludes the use of organic solvents. The selected solubilizers were sodium citrate (15%), PEG 400 (8%) and polyvinyl pyrolidine (7%). Beer’s law was obeyed in the concentration range of 2-20µg/ml at wavelength of 256nm. The solubility of ketoprofen was increased by 30 folds in the mixed cos-solvents as compared to distilled water. The recovery study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method. The low values of LOD and LOQ indicated good sensitivity of proposed method. The study proved that mixed co-solvency phenomenon is an effective technique in enhancement of aqueous solubility of poorly water soluble drugs and can be successfully employed for estimation of drugs in routine analysis of...
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Posted by admin on Apr 1, 2012 in |
Cinnamomum tamala is found in tropical and sub-tropical Himalayas and in some other places. Phytochemical screening of the plant extracts were done to screen their active constituents. Antimicrobial activity of this plant extract was investigated by Kirby-Bayer methodology against four pathogenic organisms: K. Pneumonae, E. coli, S. aureus, and P. aeroginosa. The plant Butanol extract showed inhibitory activity against all the tested organisms and it has enhanced immunomodulatory activity also. Butanol extracts containing remarkable positive results for phytochemicals compared to other solvent extracts. The higher concentration (100mg/ml) of butanol extracts shows maximum inhibition. Proliferation and activation of lymphocytes was also identified. The study scientifically validates the use of plant in traditional medicine....
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Posted by admin on Apr 1, 2012 in |
Euphorbia prostrata Ait.(Euphorbiaceae) is a small, prostrate, annual green herb sometime purple tint in colour. It is widely distributed globally and used as antihemorrhoidal, anti-inflammatory, analgesic, hypolipidemic, antidiabetic, antidirroheal, antiasthmatic and for various skin diseases. The microscopy of root shows the presence of obliterated cork cells, phelloderm, cortex, endodermis, phloem, medulary rays and xylem; the stem shows the presence of multicellular trichome, cuticle, epidermis, cortex, endodermis, pericycle, phloem, latex canal, xylem and pith; the leave reveal the presence of multicellular, multiseriate glandular hairs, epidermis, vascular bundles, stomata anomocytic and anisocytic. The vein islet number and vein termination number have also been determined. The powder study reveals the presence of epidermal cells, trichomes, parenchymatous cells, pollen grains, vessels, fibers and stomata. The water soluble, alcohol soluble and petroleum ether extractive values were determined. The total ash, water soluble ash, acid insoluble ash and sulphated ash were also observed. Preliminary phytochemical studies revealed the presence of flavonoids, tannins, glycosides and saponins in the alcoholic extract of the plant. This is the...
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