Posted by admin on Feb 1, 2012 in |
The effect of aqueous seeds extract of Trigonella foenum graecumLinn was studied on Lactate dehydrogenase (LDH) activity of blood, liver and pancreas in normal and alloxan- induced diabetic mice. Our study showed that aqueous seeds extract, Oral administration of 50 mg/animal (0.5 ml of extract) in alternative days up to 7 days (1st, 3rd, 5th & 7th day). In alloxan induced diabetic mice, there was a significant increase in LDH activity of all the three tissues. The enzyme Lactate dehydrogenase showed significant decrease in the diabetic group treated with aqueous extract of tested plant when compared with the diabetic group. It is clear from the current data in this study that ginseng aqueous extract was the most efficient of the tested...
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Posted by admin on Feb 1, 2012 in |
The objective of the project work was to study the effect of Hypoglycemic and Hypolipidemic activity of 2- hydroxychalcone on high fructose diet induced insulin resistance in male Wister Albino rats. Rats were rendered insulin resistant by feeding 66% (w/w) fructose and 1.1% (v/w) coconut oil mixed with normal pellet diet (NPD) for 3 weeks. Insulin resistance high fructose diabetic rats receiving hydroxychalcone intraperitoneally (i.p.) at the dose of 25mg/kg body weight daily for 7 consecutive days. At the end of the study blood glucose, serum insulin, glycosylated haemoglobin was estimated. The tissue was used for the assay of enzyme activity of Hexokinase, Glycogen, Glu-6-phosphatase and fru-1, 6 bis phosphatase were also estimated. Fructose diet with 2-hydroxychalcone significantly reduced the blood glucose, insulin, glu-6-phosphatase, fru-1, 6 bis phosphatase and significantly increase the hexokinase and glycogen activity. The flavonoid present in the cinnamon 2-hydroxychalcone were found to exhibit a significant Hypoglycemic activity in fructose fed insulin resistant...
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Posted by admin on Feb 1, 2012 in |
Many cytological characteristics were studied in two species of Genus Delonix i.e., D. regia and D. elata . Delonix regia possessed 2n = 28 chromosome number. Both univalent as well as bivalents occurred invariably in this plant species, the former type being predominant over latter type. The chiasma frequency per PMc varied from 8-12 with average being 15.82. The chiasma frequency per chromosome averaged 0.56. The meiosis as well as meiotic indices was quite normal. Whereas Delonix elata is concerned for the above said chromosomal characteristics, it differed minutely in the frequency of chromosomal associations and chiasma frequency (per PMc and per chromosome). It does not show any change in comparison to D. regia in chromosome number, chromosomal distribution at AI and meiotic index. However rod bivalent occurred more frequently than ring type unlike D....
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Posted by admin on Feb 1, 2012 in |
The impact of salt stress and water stress on seed germination, root and shoot length, fresh and dry biomass, vigour index was investigated in Senna (Cassia angustifolia) at germination stage (7DAS). Salinity stress was induced by using NaCl and drought stress by using PEG-6000. Different concentration of NaCl (0.1 to 100 mM) and PEG-6000(-0.1 bars to -2.0 bars) were used for seed treatment. The objective of the present investigation was to study the comparatively impact of NaCl salinity stress and water stress on seed germination, seedling growth, fresh and dry weight in...
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Posted by admin on Feb 1, 2012 in |
Quinazoline and its analogues have important therapeutic value in the treatment of cancer to induce apoptosis in cancer cells in a proliferation-independent manner. The binding free energies of quinazoline based inhibitors of kinase were computed using linear interaction energy method with a surface generalized Born (SGB) continuum solvation model in the human ALK5 kinase domain. A training set of 20 quinazoline analogues was used to build a binding affinity model for estimating the free energy of binding for 12 inhibitors (test set) with diverse structural modifications. The root mean square error (RMSE) between the experimental and predicted activity values was 0.02 µM which is comparable to the level of accuracy achieved by the most accurate methods, such as free energy perturbation (FEP) or thermodynamic integration (TI). The correlation coefficient between experimental and predicted activity based on SGB-LIE estimation for the test set compounds is also significant (R2 = 0.9693). Low levels of RMSE for the majority of inhibitors establish the structure-based LIE method as an efficient tool for generating...
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