Posted by admin on Feb 1, 2012 in |
A simple, sensitive and accurate spectrophotometric method has been developed for the deterrmination of Risperidone in raw material and capsule. The λmax of Risperidone was found to be 202nm. Risperidone obeys linearity within the concentration range of 2.5 to 20µg/mL and coefficient correlation was found to be 0.9991.The regression of the curve was Y= 0.0508X+0.0112. The %RSD value is below 2.0 for intraday and interday precision indicated that the method is highly precised. The percentage recovery value was higher than 100%, indicating the accuracy of the method and absence of interference of the excipients present in the formulation. The proposed method will be suitable for the analysis of Risperidone in bulk and pharmaceutical...
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Posted by admin on Feb 1, 2012 in |
Staphylococcus aureus causes a wide range of infection such as skin and soft tissue infection to life threatening disease like respiratory tract infection, musculoskeletal infection, endocarditis and urinary tract infection. The aim of the present study was to evaluate the possible protective effects of nanoconjugated vancomycin against VSSA infection on select makers of oxidative damage and antioxidant status in liver, kidney and spleen.A coagulase positive VSSAstrain was used for this study. VSSA infection was developed in Swiss mice by intraperitoneal injection of 5 X 106 CFU/ml bacterial solutions. Nanoconjugated vancomycin was treated to VSSA infected mice at a dose of 100 mg/kg b.w/day for 10 days. After decapitation, liver, kidney and spleen were excised from control and experimental groups, homogenized and used for different biochemical estimation. Nitrate level, myeloperoxidse activity, lipid peroxidation, protein oxidation, oxidized glutathione, DNA fragmentation level were increased significantly (p<0.05) in liver, kidney and spleen of VSSA infected group as compared to control group, and reduced glutathione level, activity of antioxidant enzymes (SOD and CAT), glutathione...
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Posted by admin on Feb 1, 2012 in |
The study aimed to access the analgesic effect of Feronia limonia (FL, leaves of Feronia limonia (L.) Swingle). The leaves of FL were extracted with 95% ethanol and the dried extract (FLE) was administered intragastically (i.g.) at 100, 200 and 400 mg/kg. Analgesic effect was evaluated in two experimental animal models. Pretreatment with single dose of FLE also produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. In addition, single dose of FLE at 2g/kg body weight produce no observable acute toxicity in mice within seven days. These results demonstrate that FLE possess analgesic effects and has no obvious acute...
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Posted by admin on Feb 1, 2012 in |
There are various drugs used in daily life. Some of them show hazardous effect on various organs and some of them shows even lethal effect. Such drugs are required to banned. One of them is Etizolam (marketed under the brand name Sedekopan, Pasaden or Depas) is a drug which is a thiebenzothiodiazepines analog. The aim of this work is done to compare the effect of administration of the etizolam drug at (Zero-day) before incubation and at the (5-day) first week of incubation, to get an idea about the extent of the teratogenic effect of this drug on the development of chick embryo. So that morphological and biochemical studies were done on the chick embryo of 8- and 16-days old chick embryos treated with (0.5mg/ml egg) of etizolam on the (zero and 5-th days) of incubation. Etizolam caused abnormality in concentration dependent manner. Enlarged remains of primitive streak was seen at 0.1mg/ml and o.3mg/ml concentration of Etizolam embryo dies. Etizolam inhibit development of somites of the development of 5-day at...
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Posted by admin on Feb 1, 2012 in |
The study has been designed to investigate the effect of aqueous extract of rind of Punica granatum in sciatic nerve ligation induced-neuropathic pain in rats. Surgical procedure was performed with sciatic nerve ligation to develop neuropathic pain in rats. The development of neuropathic pain was assessed by employing behaviour parameters such as hyperalgesia and allodynia. Further, the functionality of sciatic nerve was assessed using the histopathological study of myelinated and unmyelinated fibers in sciatic nerve. Moreover, the oxidative stress was assessed by estimating serum thiobarbituric acid reactive substances (TBARS), catalase, glutathione and tissue TBARS and Superoxide dismutase (SOD). Rats exposed to sciatic nerve ligation produced marked increase in oxidative stress, which was assessed in terms of TBARS and SOD along with decrease in the level of catalase and glutathione. Moreover, it develops neuropathic pain by impairing the normal functions of myelinated and unmyelinated fibers in sciatic nerve. Treatment with aqueous extract of Punica granatum extract (100mg/kg, p.o) markedly prevented sciatic nerve ligation-induced neuropathy and oxidative stress by increasing the...
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