Posted by admin on Mar 1, 2012 in |
The study was designed with an aim to evaluate the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of liver tissue homogenates as markers of lipid peroxidation. The study reveals the lipid peroxidation induction capacity of busulfan and the antiperoxidative potential of ascorbic acid on busulfan-induced lipid...
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Posted by admin on Mar 1, 2012 in |
The main objective of study was to formulate SEDDS of Spironolactone in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. SEDDS are isotropic mixtures of oils and surfactants, sometimes containing cosolvents. The present research work describes a Self Emulsifying Drug Delivery System (SEDDS) of Spironolactone using oils (Arachise oil, Oleic Acid, Castor oil, Soyabean Oil, Neobee M5, Migloyol, Capmul), surfactants (Tween-80, Cremophor RH40,Cremophor EL) and adsorbents (Aerosil-200,Avicel PH101,Lactose, Dextrose, Mannitol and Talc). In case of SEEDS of Spironolactone, the release rates of all oils were very rapid in Avicel PH101(above 82%) because it has the best flow property among the other absorbents. It Self Emulsifying Drug Delivery System observed that the release pattern from Arachis oil (92.95%), Oleic acid (90.21%) and Castor oil (97.54%) were better in comparison to other oils. Besides, it can be comprehend that the release rate of the three oils were very rapid in Tween-80(above 85%) because it has the best emulsifying property than Cremophor RH40 and Cremophor...
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Posted by admin on Mar 1, 2012 in |
Epilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupt the nervous system and can cause mental and physical dysfunction. Based on the ethnopharmacological information of the plant, the methanol and aqueous extract of the whole plant of MELISSA OFFICINALIS was evaluated for its antiepileptic activity in Swiss Albino Mice .Antiepileptic activity was assessed by using MES and PTZ induced models (250 and 500 mg/kg). Body weight doses were used for the present study. In the MES model the methanol and aqueous extracts showed a dose dependent reduction in the duration of hind limb extensor phase. In pentylenetetrazole induced model methanol and aqueous extracts at dose level of 500mg/kg body weight showed significant reduction in the tonic convulsions induced by PTZ when compared with control group. The results suggest a possible anticonvulsant effect of the methanol and aqueous extracts of Melissa officinalis inSwiss Albino...
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Posted by admin on Mar 1, 2012 in |
The phytochemical analysis of the medicinal plant Kalonchoe pinnata was carried out to evaluate the antioxidant potential. Alcoholic extracts of the leaves was subjected to in vitro antioxidant activity screening models such as inhibition of lipid peroxidation, nitric oxide ,superoxide radical and hydroxyl radical scavenging activity. Ascorbic acid was used as the standard for superoxide anion radical scavenging activities. Butylated Hydroxy Toluene (BHT) is used as standard for anti-lipid peroxidation activity and for nitric oxide scavenging activity Gallic acid is used as a standard. In all the models studied, the extracts showed potent antioxidant activity, thereby augmenting it into the present day system of...
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Posted by admin on Mar 1, 2012 in |
The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins. It also exhibited antioxidant activity by showing the increased activity of SOD, CAT, GPx and GRD and decreased in TBARS compared to CCl4 treated groups. Silymarin, a known hepatoprotective drug is used for comparison. The plant extracts were effective in protecting liver against injury induced by CCl4 in...
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