Posted by admin on Mar 1, 2012 in |
The development of topical anesthetics can serve as a better alternative to infiltration anaesthesia for short dermatosurgical procedures. EMLA cream (eutectic mixture of local anesthetics), a topical local anesthetic cream has been shown to penetrate intact skin and provide analgesia of superficial layers. Very few comparative studies are available and therefore data regarding the efficacy and patient acceptability of EMLA over lignocaine infiltration are limited. So, with this background the present prospective study was planned to compare the efficacy, safety and patient acceptability of topical EMLA cream with lignocaine infiltration in patients undergoing radiofrequency ablation of warts from the intact skin of face and neck. A total of 40 volunteer patients with 10 – 15 warts present on face and neck were divided into two groups (group A and B), 20 patients in each group. Group A received lignocaine infiltration and group B received topical EMLA cream under occlusive dressing. The procedure was executed after 5 min of lignocaine infiltration and 30 min of EMLA application. Pain assessment was...
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Posted by admin on Mar 1, 2012 in |
Identification of protein-ligand interactionnetworks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics. In this study we have developed a novel computational strategy to identify ligand binding profiles of proteins across gene families and applied it to predicting protein functions, elucidating molecular mechanisms of drug adverse effects, and repositioning safe pharmaceuticals to treat different diseases The resultant network is then extrapolated to proteomics level to sort out the genes only expressed in the specific cancer types. The network is statistically analyzed and represented by the graphical interpretation to encounter the hub nodes. The objective of developing a biological networking is for the evaluation and validation of cancer drugs and their targets. In the field of cancer biology, the drug and their targets holds a role of paramount importance. With the work conducted here it shows the study of relation between drug target networks. Kaposi’s sarcoma (KS) is a systemic disease...
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Posted by admin on Mar 1, 2012 in |
Protective effect of Cassia auriculata Linn., floral extract was examined against Isoproterenol induced Myocardial infarction in male albino rats. The oral administration of aqueous extract of Cassia auriculata, afforded protection against Isoproterenol induced alterations in Cholesterol, LDL, HDL, TG, Protein, AST, ALT, LDH, Catalase and GPx. The protective effect was further supported by the histological observations. The results clearly demonstrate that Cassia auriculata flowers have potent cardioprotective...
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Posted by admin on Mar 1, 2012 in |
Ondansetron is the first of a new class of drugs, selective serotonin receptor antagonist (5 hydroxy tryptamine type 3) used as an anti emetic associated with cancer chemotherapy. Its Orally Disintegrating Tablet has been developed for patients who find swallowing difficult by freeze dried technology by RP Scherer Corporation and Scherer DDS. The aim of this study was to design a new orally disintegrating tablet that has high hardness and a fast disintegration rate using conventional tablet technology. Ondansetron ODT was prepared by using traditional technology like direct compression and wet granulation technique. As blend exhibited poor flow in direct compression process, so wet granulation process was finalized. Bitter taste of Ondansetron has been masked by use of sweetener like aspartame and peppermint flavor. Quick disintegration has been achieved by use of surfactant in the granulating solvent and superdisintegrant like crospovidone in both intra and extragranular part. Design space has been created by use of different concentrations of both binders as well as disintegrant with the help of DOE...
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Posted by admin on Mar 1, 2012 in |
Cichorium intybus Linn (Compositae) contains UV-absorbing metabolites. Studies on methanol extract of Cichorium intybus Linn by means of HPLC-UV, NMR, HPLC-MS resulted in isolation and identification of three previously unknown flavones glycosides: 5, 6, 7, 3′, 4′, 7′-hexahydroxy flavones-7-O-β-D-glucopyranoside (1), 3, 5, 7 – trihydroxy-3′,4′-dimethoxy-flavone-7-O-β-D-galactopyranosyl-(1→4)-β-D-xylopyranosyl-3-O-α-L-rhamnopyranoside (2), 3, 5, 7-trihydroxy-6, 4′-dimethoxy flavones (3) also isolated were three known flavones, luteolin (4), ladanetin (5) and spicoside...
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