Posted by admin on May 1, 2012 in |
Polymethyl mehtacrylates polymers such as Eudragit RL100 have been used in preparation of matrix type oral sustained release, coating and in microencapsulation of drug. Embedding of drug within an insoluble matrix is convenient way of controlling the drug release.The prepared microspheres by emulsion solvent evaporation technique was simple and reproducible, possessed good sphericity, smooth surface morphology, uniform and narrow size distribution (170-200 μm), when analyzed by scanning electron microscopy, and optical microscopy. Method of preparation has influenced the particle size and drug loading efficiency. The carrier ethyl cellulose and Eudragit RL100 are easily available and compatible. Drug-polymer compatibility was confirmed by Fourier transform infrared spectroscopy and DSC and X-ray diffraction studies revealed that the drug was dispersed inside the microspheres in the form of an insoluble matrix. The formation of microspheres was affected by glass transition temperature of the polymer, surfactant, type of plasticizers, volume of internal phase, stirrer speed etc. IR of Eudragit RL indicated high thermal stability of the polymer. Percentage loading increases with the increase in...
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Posted by admin on May 1, 2012 in |
Costus speciosus belongs to the family Zingiberaceae and contains lots of medicinal properties. The aim of this study was to screen, characterise and quantify the selected biomolecules viz. phenolics, proteins in C. speciosus. Ethanol extract possessed high amount of phenolics than the acetone and aqueous extract. Aqueous extract has least amount of phenolics compared to ethanol and acetone extracts. The protein contents were high in phosphate buffer as compared to the aqueous extract. Qualitative estimation of phenolic compounds was accomplished by reverse phase high pressure liquid chromatography. High amount of phenolic content was found in the mature leaf of C....
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Posted by admin on May 1, 2012 in |
Three different solvent extracts of seeds of Annona squamosa L. were studied for its antibacterial activity. Agar cup method was selected to test antibacterial activity using two Gram-positive (Bacillus subtilis, Staphylococcus aureus) and three Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria. The screeningresults showed that highest inhibition was observed by the methanol extract followed bypetroleum ether and chloroform extracts for Annona squamosa seed. Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus are the most sensitive bacterial strains among all test...
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Posted by admin on May 1, 2012 in |
Casuarina equisetifolia (Casuarinaceae) is considered a medicinal plant and is traditionally used for the treatment of diarrhoea. Preliminary phytochemical screening of methanolic extract of the aerial bark revealed the presence of carbohydrates, alkaloids, proteins, glycosides, saponins, flavonoids and tannins. The extract reduced contractions in isolated ileum induced by spasmogens like ACh, Histamine, KCl and BaCl2 and potentiated the effect of Nifedipine suggesting an antimuscarinic, antihistaminic and a calcium channel blocking action. Flavonoids and tannins present in the extract might be responsible for the observed antispasmodic effect and suggests multiple mechanisms, which can be exploited in future...
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Posted by admin on May 1, 2012 in |
The present study was designed to evaluate the heavy metal absorbing potential of bacteria isolated from industry effluent sites of river Nagavali, Srikakulam Andhra Pradesh. From the effluent waste water three bacteria were isolated and confirmed as Staphylococcus aureus and Staphylococcus epidermidis and Staphylococcus saprophyticus after performing various biochemical tests. The heavy metal tolerant efficiency was determined by analyzing the growth of the bacteria in presence of heavy metal (Cu, Hg, Co and Zn) solution and their optimum tolerance was determined by measuring the optical density at 600nm after 24hr and 48hr of incubation. Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus saprophyticus were found to grow in heavy metal...
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