Posted by admin on Feb 1, 2012 in |
The purpose of the present study is to prepare different combinations of drug Simvastatin (SV) with different polymers like Sodium alginate (SA), Hydroxypropylmethylcellulose (HPMC), Pectin (P), Dillenia (D) and Hydroxy propyl β- cyclodextrin. (HPC), thereby determine and report any possible interactions between the drug Simvastatin (SV) and various polymers both from natural and synthetic sources. The natural plant fruit seed mucilage Dillenia(D) was extracted from the plant Dillenia indica ,Family Dilleniaceae and was dried. Individual polymers and their combinations with drug SV were tested analytically and comparison of the results was done to find out any interactions. The analytical techniques used for the purpose are Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetric analysis (TGA). The techniques of FTIR and TGA serves as a good means for determination of any interactions as the change in characteristics of the drug peak and its melting point can be detected by the two techniques respectively. From the study it was Simvastatin when complexed with Hydroxy propyl beta cyclodextrin (HP) showed some changes but...
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Posted by admin on Feb 1, 2012 in |
Most of the plant parts of Syzygium cumini aredocumented in the traditional systems of medicine in India for their key usage as a hypoglycemic in the management of diabetes. Many such formulations of Jamun fruits/seed powder are available in the market. Hence, in the present investigation, the detailed pharmacognostic evaluation of Syzygium cumini seed powders has been carried out to develop a fast, easy and efficient protocol for the authentication of the formulations of Jamun available in the market. Also, an effort has been made to quantitate the gallic acid component of tannins using different chromatographic and spectrophotometric techniques....
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Posted by admin on Feb 1, 2012 in |
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of cefpodoxime proxetil and ofloxacin in combined tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Cefpodoxime proxetil has absorabance maxima at 236 nm and ofloxacin has absorbance maxima at 299 nm in methanol. The linearity was obtained in the concentration range of 5-29 μg/ ml and 1-13 μg/ml for cefpodoxime proxetil and ofloxacin respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The suitability of this method for the quantitative determination of cefpodoxime proxetil and ofloxacin was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of cefpodoxime proxetil and ofloxacin in pharmaceutical dosage form. The result of analysis has been validated statistically and...
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Posted by admin on Feb 1, 2012 in |
The safety and efficacy of a pharmaceutical dosage form can be guaranteed when its quality is reliable. The efficacy of pharmaceutical dosage forms generally depends on their formulation properties, and manufacturing methods, hence it is likely that the quality of dosage form may vary. The aim was to evaluate the quality of paracetamol tablet marketed in Somali region of Ethiopia. The study was exclusively experimental that used BP, USP and other standard books to check the in vitro quality of Paracetamol tablet using different analytical techniques and procedure. Test for weight variation, friability, disintegration time, identification test and assay were conducted. All of the brands under the study were within the specification for weight variation test. But from the contraband brands, two for friability, one for disintegration and all for percentage content paracetamol failed to satisfy the requirement though all of the products contain the wright active ingredients. The research has showed that the quality of contraband tablets were below the standard in contrast to the legal paracetamol tablet...
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Posted by admin on Feb 1, 2012 in |
Trihexyphenidyle is a lipophilic antiparkinsonian drug with short half life. Practically slightly soluble in water makes formulation and delivery difficult. By formulating the same in the microcapsule by using biodegradable polymer Eudrajit L 100 and S 100, the half life and solubility can be altered and hence drug release pattern. Trihexyphenidyle microcapsules were prepared by solvent evaporation method by using different drug-polymer ratio (1:2, 1:3, 1:4, 1:5). Prepared microcapsules were evaluated for the particle size, percentage yield, incorporation efficiency, flow property and in vitro drug release at pH 6.8 for 12 hours. From the result we can conclude that as the concentration of polymer increases, it affects the particle size, percentage yield and drug release of micro capsules. The formulation F2 shows the excellent flow properties, particle size, percentage yield (91.24%), incorporation efficiency (94.59%) and percentage drug release (95.88%) for a period of 12 hrs. Results of the present study indicate that Trihexyphenidyle microcapsules can be successfully designed to develop sustained drug delivery, that reduces the dosing frequency and...
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