Posted by admin on Nov 1, 2011 in |
Bacopa monnieri Linn. is an important medicinal plant belonging to family scrophulariaceae. Bacopa is a neurotonic, immuno-modulator, tranquilizing, memory and learning enhancing, cerebral activator, anti-ulcer, antispasmodic, anti-asthmatic. It is also used in Epilepsy, anxiety and depression. Major component of Bacopa are saponins Bacoside A and Bacoside B. The cell suspension culture of Bacopa monnieri was treated with 0.2%, 0.6% and 1% concentrations of DMSO (Dimethyl sulphoxide), a cell permeabilizing agent for 3 and 6 hours. The samples were analyzed for the content of bacoside A using HPTLC technique to identify and quantify the amount of released product. Maximum release of bioactive compound, Bacoside A was observed (4.6±0.02µg/mg) in suspension culture treated with 1% DMSO for 3 and 6 hrs treatment durations compared to control (2.1±0.05 and 3.2±0.01,...
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Posted by admin on Nov 1, 2011 in |
Purpose: Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles to epithelial ovarian cancer (EOC). The purpose of this study is to present a case history, treatment & review the current available literature on PFTC. Material, methods and results: Early clinical presentation and prompt investigation often lead to diagnosis at an early stage. The diagnosis of PFTC is rarely done preoperatively and is usually detected by the pathologist. Surgical staging, management and the use of combination chemotherapy based on concepts similar of epithelial ovarian cancer (EOC).The timely diagnosis of PFTC leads to better survival compared with EOC. However, as with EOC, stage and residual tumors are the most important prognostic variables. Conclusion: Tumors of the fallopian tube can be suspected pre-operatively with current radiological facilities. Aggressive clinical search should also be made for a concomitant primary or as an isolated metastatic secondary of another primary cancer. Until more extensive clinical research has been performed, ovarian carcinoma management principles should be used in clinical...
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Posted by admin on Nov 1, 2011 in |
Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods were reported in the literature for the simultaneous determination of FH and OZ from combined dosage forms. In the present investigation an attempt has been made to develop accurate, reproducible, rapid and cost-effective method for simultaneous determination of FH and OZ in pharmaceutical formulation. The wavelengths selected for determination of FH and OZ is 235.5nm and 296nm, respectively. The beer’s law was obeyed in the concentration range of 8-80μg/mL and 2-20μg/mL for Fluoxetine and Olanzapine, respectively. The proposed methods were validated and successfully applied to the determination of FH and OZ in tablet formulations. The results suggested that the proposed procedures can be used for routine quality control of tablets containing FH and...
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Posted by admin on Nov 1, 2011 in |
Moringa preparations have been cited in the scientific literature as having antibiotic, antitrypanosomal, hypotensive, and antispasmodic, antiulcer, anti-inflammatory, hypo-cholesterolemic, and hypoglycemic activities, as well as having considerable efficacy in water purification by flocculation, sedimentation, antibiosis. To evaluate the antioxidant activity of Moringa oleifera leaf extracts and their in- vitro antibacterial activity against four microorganisms, viz. Escherichia Coli, Bacillus subtilis, Staphylococcus aureus and Salmonella typhii. Phytochemical screening of the leaf extracts in solvents of varying polarity; viz., water, methanol, ethanol and acetone were also carried out. The antioxidant activity of the extracts was determined by the reducing power assay using ascorbic acid as standard. Well diffusion method was used to assess the antimicrobial effect of the extracts on both Gram positive and Gram negative micro-organisms. Well known chemical procedures were used for the detection of the phytochemical components. The aqueous extract exhibited maximum antioxidant activity compared to the organic solvent extracts. Acetone extract showed broad spectrum antimicrobial effect against all the tested micro-organisms while the methanolic extract was active against...
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Posted by admin on Oct 1, 2011 in |
A number of 2-amino-4-(2′, 5′-dimethyl-3′-furyl)-6-(aryl)-pyrimidines 4(a-n) have been synthesized by treating the 1-(2′, 5′-dimethyl-3′-furyl)-3-(aryl)-2-propen-1-one (3a-n) with guanidine hydrochloride in presence of potassium hydroxide and ethanol. All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. When these compounds were evaluated for anticancer activity, some of them were found to possess significant...
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