Posted by admin on Jan 1, 2012 in |
Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been...
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Posted by admin on Jan 1, 2012 in |
CLX (celecoxib) is a highly hydrophobic non-steroidal anti-inflammatory drug with high plasma protein binding. We describe here the encapsulation of CLX in MLVs composed of SPC and variable amounts of cholesterol. The influence of drug – lipid ratio was studied and amount of the drug could be encapsulated was optimized. The effect of cholesterol and other process parameters were studied to obtain the liposomal vesicles with desired quality. All the prepared formulations were characterized for their physico chemical properties such as appearance, vesicle size, vesicle size distribution and percentage drug entrapment. Stability of the liposomes in terms of their drug leakage and drug retention behaviour was studied by storing the liposomal formulations under different conditions for the period of 30 days. The optimized formulation parameters and process parameters resulted the liposomes with mean vesicle diameter of 4.81μ. The maximum percentage drug entrapment was achieved with the formulation CL3 which contains the drug – lipid ratio of 1:10%W/W and the percentage drug entrapment is equal to 72.33±0.64 (%). In vitro...
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Posted by admin on Jan 1, 2012 in |
The present study was aimed to investigate the effects of bark extract of Terminalia arjuna (6.75mg/kg of body weight) on caffeine (10 mg/kg body weight) induced coronary heart disease. Male wistar rats weighing about 120 and 160g were used as the experimental animal for the study. Caffeine dissolved in physiological saline (Nacl) with a pH of 7.0 administered orally to wistar rats continuosly for about 14 days. Thereafter, all the animals at the end of experiment showed a significant elevation in level of total cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides and also a decreased level of HDL-cholesterol, (P< 0.01). When compared to the control rats, co-treatment of rats with caffeine and Terminalia arjuna resulted in an increase in HDL-cholesterol, decrease in serum total cholesterol, triglycerides, LDL cholesterol and VLDL cholesterol as compared to caffeine treated animals with a significant of p<0.05. These findings suggest that the bark extract of Terminalia arjuna has protective effects against caffeine induced coronary heart disease and may have potential as a cardioprotective...
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Posted by admin on Jan 1, 2012 in |
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Amlodipine Besylate, Valsartan, Telmisartan and diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (150 mm × 4.6 mm) 5 μm column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 consisted of 0.05 M sodium dihydrogen phosphate buffer and acetonitrile (Gradient ratio). The UV detection was carried out at 220 nm. The method was successfully validated in accordance to ICH guidelines. Further, the validated method was applied for commercially available pharmaceutical dosage...
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Posted by admin on Jan 1, 2012 in |
Paracetamol was formulated as lozenges to provide slow release medicament for the management of fever and pain. There are many dosage forms like syrups, tablets, inhalers are available in the market but still there is a need for new dosage forms which acts effectively and locally. So the present investigation has been taken up to design, prepare and evaluated tablet lozenges to meet the need of improved bioavailability and hence avoid hepatic toxicity. The benefits of these prepared lozenges showed increase in bioavailability, reduction in gastric irritation by passing of 1st pass metabolism and increase in onset of action. The lozenges were prepared using sucrose as base; Sodium Carboxy Methyl Cellulose (NaCMC) and Methyl Cellulose(MC) are used as polymers. Eudragit is used as taste masking agent. All the formulations prepared were subjected to various physicochemical parameters like hardness, content uniformity, friability, weight variation etc. The prepared formulations have a hardness of 9-10 Kg/cm², not gritty, mouth feel freshness taste. Stability studies of selected formulations were also carried out at...
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