Posted by admin on Oct 1, 2011 in |
To determine the anticonvulsant activity of the leaf extract of Erythrina Indica in mice and rats, and in order to verify the traditional use of the plant in the treatment of epilepsy. The pentyleneterazole (PTZ) and the maximal electroshock seizure (MES) models were used for assessing the anticonvulsant effects of the chloroform leaf extract in mice and rats. The chloroform extract (500 mg/kg p.o) of that produced significant protection (71.4%) against PTZ-induced convulsion and onset of seizures compared with the control group in mice. At 500 mg/kg p.o., the extract also produced sig-nificant protection (71.4%) against MES-induced convulsions in mice. The results obtained from this study indicate that the chloroform leaf extract of Erythrina Indica may be beneficial in both absence and tonic clonic...
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Posted by admin on Oct 1, 2011 in |
Zymodyne Syrup is poly herbal formulation made by Ayrulab Herbals Pvt. Ltd., as an appetite enhancer. This formulation contains various 17 plant extract from these 6 plants namely Cyperus rotundus, Bacopa monnieri, Glycyrrhiza glabra, Phyllanthus amarus, Asparagus racemosus, and Tribulus terrestris contains Quercetin flavonoid as a chemical constitute and it can be determined by HPTLC method. The concentration of Quercetin in formulation was 0.1100 mcg/ml and in individual extracts were 0.870, 0.783, 0.782, 0.855, 0.875, 0.957 mcg/ml respectively. This study may provide useful information in searching the role of Quercetin to enhance appetite...
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Posted by admin on Oct 1, 2011 in |
The study was designed to determine the relative bioavailability of two sustained release Fixed dose combination (FDC) products of two manufacturers containing Lornoxicam [CAS No. 70374-39-9] 8mg and Thiocolchicoside [CAS No. 602-41-5] 8mg in 24 healthy male volunteers. The pharmacokinetics of Lornoxicam and Thiocolchicoside individually after oral administration of tablet formulation has been extensively evaluated in adult volunteers. However, no published data are available regarding the combined pharmacokinetics and bioavailability of this particular fixed dose combination. The clinical study was randomized, balanced, open-label, 2-period cross-over study. Each subject was randomized at the beginning of the study to receive either a single dose of test fixed dose combination or reference fixed dose combination during Period I. Following a 7-day wash out period, all subjects received the alternate formulation during Period II. No statistically significant differences were obtained between the two products with respect to the mean concentration-time profiles or in the pharmacokinetic parameters, including area under the serum concentration-time curve from the present study. The relative extent of absorption as...
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Posted by admin on Oct 1, 2011 in |
Aim of the study: Now a days due to the hammering of movies and fashion most of the people specifically age group between 18 to 30 years, are diverted more to have the protein supplements in excess for getting good physique and well toned body shape. The people suppose to eat more calcium, vitamins and some steroids with intension that they will get done the things too fast. Without been having good trainee and medical supervisor most of the people doing exercise in the fitness club and gym and taking the diet which is one of the major cause of nephrotoxicity. Materials and Methods: Ethanolic extract of stem barks of Crataeva nurvula Buch hum in the doses of 200 mg, 400 mg and 600 mg is useful as a laxative, demulcent, stomachic, and is reported to cure disorders of urinary organs. It is also very useful as anti-inflammatory drug and act as a good contraceptive for women and also used in arthritis. Results: In the current study, effects of...
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Posted by admin on Oct 1, 2011 in |
A new, simple, safe, accurate and reproducible spectrophotometric analytical method was developed for the quantitative estimation of gatifloxacin in solid dosage form by mixed hydrotropic agents. The enhancement of solubility of drug gatifloxacin was more than 15 fold in mixed hydrotropic solution (20% N,N dimethyl urea and 20% sodium citrate solution) as compared to solubility in distilled water. Therefore, it was thought worthwhile to solubilize this poorly water soluble drug from fine powder of its tablets by this novel mixed hydrotropic solubilization technique and then carryout its spectrophotometric estimation at 333 nm (20% N,N dimethyl urea and 20% sodium citrate being non-interfering in the estimation). The results of the analysis were validated statistically and by recovery studies & its follows Beer’s law in concentration range of 10-60 mcg/ml. The percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error. Thus, the method was accurate providing additional advantage of being cost effective and environment...
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