Posted by admin on Aug 1, 2011 in |
Antibiotics are not chemically stable in water based oral pharmaceutical suspensions. Anhydrous liquid antibiotic suspension for oral administration provides a product having good shelf life and taste characteristics relative to conventional liquid formulations. A ready to use oil based cefpodoxime proxetil preparation which can be stored at room temperature was prepared and evaluated for its organoleptic properties, viscosity, flow behavior and accelerated physical and chemical stability. The formulation showed improved redispersibility, good taste masking of the bitter drug and allows the product to be stored longer preventing hydrolysis of the...
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Posted by admin on Aug 1, 2011 in |
Urinary tract infections are common type of pathogenic infections in body. Essential oils of Coleus aromaticus and two varieties of Ocimum sanctum (Rama Tulasi and Shyama Tulasi) were compared for antibacterial activity against urinary tract infection (UTI) causing bacteria; Staphylococcus aureus, Klebsiella oxytoca, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. Ocimum sanctum (Rama Tulasi) and Coleus aromaticus oils showed remarkable activity, later being more active. Least activity was observed in Shyama Tulasi variety of Ocimum sanctum. Constituents of the oils were analyzed by GC-MS and GC-FID. The essential oils have promising inhibitory effect with minimal inhibitory concentration (MIC) ranging from 0.5μl/ml -6μl/ml. The essential oils of two varieties of Ocimum sanctum have differences both in chemical composition and MIC values against UTI infection causing...
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Posted by admin on Aug 1, 2011 in |
Many patients are express difficulty in swallowing tablets and hard gelatin capsules tending to non compliance and ineffective therapy. In the present work, fast dissolving tablets of metoprolol tartrate are formulated with a view to enhance the patient compliance. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect. Hence the main objective of the study was to formulate fast dissolving tablets of Metoprolol tartrate to achieve a better dissolution rate and further improving the bioavailability of the drug. These tablets prepared with a various concentration (4%, 5%, 6%w/w) of superdisintegrants such as crosscarmellose sodium (CCS), crosspovidone (CP) and pregelatinized starch (PGS) along with directly compressible mannitol to enhance mouth feel. The prepared tablet were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, wetting time, water absorption ratio and in- vitro dispersion time, in- vitro disintegration and in- vitro dissolution profile are found satisfactory. Among the nine formulations, the formulation F9 containing pregelatinized starch...
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Posted by admin on Aug 1, 2011 in |
A new, simple, precise, rapid and accurate RP-HPLC (Reverse Phase – High Performance Liquid Chromatography) method has been developed for the simultaneous estimation of Atenolol (AT) and Amlodipine Besylate (AB) in bulk and in tablet formulations. The chromatographic separation was achieved on Agilent technologies 1200 series HPLC using Inertsil C18, 5 mm, 250 mm x 4.6 mm column maintained at ambient temperature with mobile phase, Buffer: Acetonitrile: Methanol (4:3.5:2.5 v/v/v), flow rate 1.0 ml/min, load volume 10 μl and a run time of 10 min. The UV detection was performed at 225 nm. Buffer was prepared with Triethylamine and adjusted pH to 3.0 with Ortho-Phosphoric Acid. The retention time and mean recoveries obtained for AT was 2.23 min and 100.1%, for AB was 5.97 min and 100.4% respectively. Linearity response was established over the concentration range of 50-150 μg/ml for AT and 5-15 μg/ml for AB. The correlation coefficient for AT and AB was 0.9992 and 0.9998 respectively. The recovery studies ascertained the accuracy of proposed method and the...
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Posted by admin on Aug 1, 2011 in |
A simple and cost effective spectrophotometric method is described for the determination of flupenthixol dihydrochloride in pure form and in pharmaceutical formulations. The drug was highly soluble in methanol so it was selected as the solvent system for the drug. This ensured adequate drug solubility and maximum assay sensitivity. The linearity range for flupenthixol dihydrochloride at its wavelength of detection of 230 nm was obtained as 1-15 µg/ml. The linear regression equation obtained by least square regression method, were Y = 0.0639X + 0.0013, where Y is the absorbance and X is the concentration (in µg/ml) of pure drug solution. The absorbance was found to increase linearly with increasing concentration of flupenthixol dihydrochloride, which is corroborated by the calculated correlation coefficient value of 0.9997. The limit of detection and limit of quantification was found to be 0.324 µg/ml & 0.982 µg/ml. The validity of the described procedure was assessed. Statistical analysis of the result has been carried out revealing high accuracy and good precision. The proposed method was successfully...
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