Posted by admin on Jul 31, 2023 in |
Proton Pump Inhibitors (PPIs) are widely used acid suppression medications for many conditions. PPIs class includes many drugs, such as omeprazole, lansoprazole, pantoprazole and esomeprazole, available orally in a tablet/capsule form. PPI’s products have reasonably high prices with quality differences that most healthcare providers must know. Therefore, this study aimed to compare the quality of PPIs for brand and generics in the Saudi market. Gastric ulcers result from an imbalance involving gastric protection and aggressive factors. Gastric protection depends on several factors, such as the release of prostaglandin E2 (PGE2), bicarbonate secretion, gastric mucus production, and gastric mucosal blood flow regulation. Factors leading to gastric offensives are the hypersecretion of H.C.L. or pepsin. Ethanol is well known to induce gastric ulcers via multi-factorial mechanisms such as the impairment of gastric defensive factors like mucus dissolution or by increasing offensive factors such as acid secretion or gastrin release. Our study reveals that the gastroprotective effect of PPIs marketed in Saudi Arabia has significantly protected the gastric mucosa against ethanol...
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Posted by admin on Jul 31, 2023 in |
Contrast-induced nephropathy (CIN) is a frequent cause of hospital-acquired acute kidney injury (AKI) and is associated with adverse clinical outcome. It occurs often among patients with multiple comorbidities and compromised renal function. This study is aimed to determine the prevalence of the risk factors associated with contrast-induced nephropathy in patients undergoing various percutaneous coronary interventions (PCI). A prospective observational cross-sectional study was conducted in a tertiary care hospital for 12 months. Patients undergoing PCI were recruited in accordance with the eligibility criteria. The baseline characteristics as well as laboratory and cath-lab procedure data, were obtained from their case files. The prevalence of risk factors among the patients was assessed using the Mehran score and the association of risk factors with CIN was analysed using binary logistic regression. CIN was prevalent in 30 (15%) out of 200 recruited patients. The prevalence of risk factors among the recruited patients was 8.5% aged > 75 yrs, 11% hypotensive, 9% requiring an intra-aortic balloon pump, 44% anaemic, 36% diabetic, and 4.5% having serum...
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Posted by admin on Jul 31, 2023 in |
Dendrocnide sinuate (Blume) has been widely used in the treatment of various diseases. The plant Dendrocnide sinuate (Blume) belonging to the family Urticaceae. Many indigenous peoples used this herb to treat swelling, fever, and urinary disorders. The karbis tribes also used it as a hypersensitivity therapy. The Bodo people of Assam gather the flowers of Dendrocnide sinuata (blume) and use them as a portion of food with fish. The plant extract was subjected to a preliminary phytochemical analysis, which revealed the presence of carbohydrate, tannin, flavanoid, phenol, terpenoids, cardiac glycoside, alkaloid. As part of the investigation on the mechanism of the anti-inflammation activity, plant extract’s ability to stabilize human red blood cells membrane was studied. It was effective in the stabilization of the human red blood cells membrane. Maximum stabilization of 65.03% was observed at 150µg/ml. Diclofenac, a standard anti-inflammation drug, showed a maximum stabilization of 54.08% at 150 µg/ml concentration compared with...
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Posted by admin on Jul 31, 2023 in |
Catharanthus roseus (periwinkle) is a medicinal plant that belongs to the Apocynaceae family. All parts of this plant are used as medicine according to ancient medicinal systems. In this research paper, plant leaf samples undergo phytochemical investigation through gas chromatography-mass spectrometry (GC-MS). As the result of GC-MS spectra we identified twenty-three phytochemical compounds in methanolic extract of C. roseus leaves. The identification of phytochemical compounds is based on the peak area, retention time, molecular weight and molecular formula. Compounds present to a major extent are specified with their NMR, IR, and Mass spectrometry data. This spectral analysis helps in the discovery of novel phytochemicals in the plant extract of this plant. We can guess about any novel phytochemicals that can be further used as synthetic units in organic synthesis reactions because natural synthetic units used in any process will always be environmentally friendly and follow green chemistry...
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Posted by admin on Jul 31, 2023 in |
A new simple High-Performance Thin Layer Chromato-graphic (HPTLC) method for determining Paracetamol, Diclofenac and Caffeine in combined tablet dosage form has been developed and validated. The mobile phase selected was Ethyl acetate: Methanol: ammonia (8: 2:0.1 v/v/v) with UV detection at 263 nm. The retention factor for Paracetamol, Diclofenac, and caffeine was found to be 0.639 ± 0.018, 0.267 ± 0.026, and 0.447 ± 0.026, respectively. The method was validated with respect to linearity, accuracy, precision and robustness as per the International Conference on Harmonization (ICH) guidelines. Results were found to be linear in the concentration range of 1000-6000 ng/band for Paracetamol 200-1200 ng/band for Diclofenac and 100-600 ng/band for caffeine, respectively. The method has been successfully applied to analyze drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 98.64 ± 0.184 for paracetamol, 97.17± 1.074 for Diclofenac and 98.27± 0.86 caffeine. The method can be used for routine analysis of these drugs in combined tablet dosage forms in quality-control...
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