Posted by admin on Apr 30, 2023 in |
The in-vitro drug release profile from a hydrophilic matrix tablet is influenced by the viscosity of the gel layer formed due to its polymer hydration, and it depends on various other physical properties like a drug: polymer ratio water-solubility and particle size of the drug, particle size and type of the polymer, type of diluents used, and temperature of media. The drug release profile of different formulations i.e., C1to C6 formulated by utilizing Hypromellose K4M, Hypromellose K15M and Hypromellose K100M Respectively. K4M, which is low viscosity polymer, shows a faster release at initial time points. Hypromellose polymer (K100M) is hydrophilic in nature, showing fast hydration and controlling the dissolution profile. The dissolution profile of batch C1 to C2 having drug (Metformin HCl): polymer ratio 1:0.25 and 1:0.5 gives little controlled release profiles of the drug in C1, C2. Hence, 1:0.5 drug (Metformin HCl) to HPMC K100M was used for further study. It had been observed that HPMC K15M and K4M could not retard the release rate sufficiently to get...
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Posted by admin on Apr 30, 2023 in |
Hypercholesterolemia occurs when a high cholesterol level in the blood may lead to atherosclerosis. Scavenger receptor class B type 1 (SR-B1) is a protein found on the surface of various cells that facilitates the reverse cholesterol transport or efflux of cholesterol from peripheral tissues back to the liver. SR-B1 receives cholesterol from high-density lipoprotein (HDL), which is then transported and metabolized in the liver cells. In this study, the compound methyl benzoate isolated from Acanthaster planci was investigated for its ability to reduce hypercholesterolemia by increasing the expression of the SR-B1 gene. Using MTS assay, methyl benzoate showed a non-cytotoxic effect on hepatocellular liver carcinoma (HepG2) cells. The luciferase assay revealed that methyl benzoate increased SR-B1 promoter activity by 1.23-fold compared to the negative control. The expression of SR-B1 gene examined by real-time polymerase chain reaction (RT-PCR) increased the expression by 1.24-fold higher than that of the positive control. In addition, HDL uptake increased by 5% in the methyl benzoate-treated cells. As for the in-vivo model, methyl benzoate was...
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Posted by admin on Apr 30, 2023 in |
Incorporating the under-consumed super food ingredients rich in nutrients or functional compounds is a growing concern in healthcare product formulation. Health-ensuring cookies blend with Nelumbonucifera (Lotus) stem powder were standardized in the laboratory and found its acceptable form with comparatively higher acceptability and good flavour profile. Safety assurance is also a part of product development to assure and instruct the consumer regarding its life span or safe consumption time on storage duration. Therefore, the study further aimed at to- Aims and Objective: 1. To assess the quality of lotus stem cookies in terms of microbiological and organoleptic aspects. 2. To assess the impact of the growth of microorganisms in cookies prepared through blend of lotus stem powder. Methodology: Keeping quality of this formulated product has been assessed by enumerating the total bacteria, yeast and mould count in between a fixed time duration (0 – 90 days) and assessing its sensory qualities. AOAC (1994) suggested techniques (microbiological count assessment) and 9 point hedonic scale to observe the flavour profile were...
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Posted by admin on Apr 30, 2023 in |
Background: Pain is warning signal of the underlying pathology and is also essential for the diagnosis. Vanilla planifolia (VP) as per literature has analgesic activity. Analgesics like NSAIDs and Opioids are used for treating pain. Adverse effects limits their long-term use. Therefore, there is always a need of more effective and safe drugs. Objective: To evaluate the analgesic activity of ethanolic extract of Vanilla planifolia seeds. Material and Methods: Wistar rats weighing 150-200gms and mice 30-40 gms of either sex were included in the study. Hot plate model and acetic acid-induced writhing test was used. Animals were divided into four groups -Vehicle control, Standard control, VP Low Dose and VP High Dose. Drug treatment was given 1hr prior to the test & response to the thermal stimuli was noted on eddy’s hot plate. Drug treatment was given 1 h before and number of writhes was measured, at different time intervals 30 min up to 240 min after the injection of 1% acetic acid in writhing test. Data analyzed with...
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Posted by admin on Apr 30, 2023 in |
In the present COVID-19 situation, it poses a danger to a person’s life because of organ infection and other health problems. It is mandatory to research work to find a better COVID-19 infection diagnosis method through scans and contact tracing through the AI method. In this, a novel AI structural model is intended to identify the infection features in the respective regions of human being availability, which makes the infection monitoring easier to identify an infected and non-infected human being from the population identified. The method used for monitoring the multiplicative nature of Coronavirus infections is through contact feature tracing and infection confirmation status and confirms the Coronavirus cases from scans and feature analysis to include real-time contact tracking from the same region and distant regions, providing an efficient method to track the infection spread. The anticipated model is used to forecast coronavirus transmission using feature forecasting data. The performance assessment is compared based on the outcomes of the suggested model and shows an enhanced COVID-19 diagnostic...
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