Posted by admin on Aug 1, 2011 in |
Ixora pavetta Vahl. is a small tree, traditionally used for the treatment of diarrhoea, dysentery, urinary disorders, leucorrhoea, veneral diseases and sedative. The flowers of the plant were extracted with ethanol by cold percolation method. The presence of the compounds in the extract was analyzed by GC-MS technique. The parameters of mass spectral analysis viz. retention time and characteristics of peak using NIST library were considered for the detection of compounds, The compounds viz. 3-Butyn-2-ol, 3-Butyn-1-ol, Amyl nitrite, 2Octyn-1-ol, 1, 9-Decadiyne and Butyl glyoxylate were identified from the study. With reference to the phytochemical and ethanobotanical databases, the Pharmacological activity of the compounds which identified were found out and compared with its traditional uses. Sedative property is one of the traditional uses of Ixora pavetta was found to be due to the presence of Amyl nitrite in the extract....
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Posted by admin on Aug 1, 2011 in |
Andrographis paniculata Nees. is an important medicinal plant in India which is used in traditional medicine. Although, its antibacterial property has been shown by some researchers, there are very few studies showing its antioxidant activity and there are no reports of its antifungal activity against dermatophytes. So, in this study we evaluate the antibacterial, antifungal and antioxidant activities of A. paniculata leaves in different solvent extracts. A. paniculata leaves were extracted with chloroform, hexane, methanol, ethanol and water separately and phenol and flavonoid contents were estimated in these extracts. The antibacterial and antifungal activity studies were carried out by using disc diffusion method and mycelial dry weight method respectively. Ferrous reducing antioxidant power assay, 1, 1-diphenyl-2-picryl hydrazyl (DPPH) scavenging activity, lipid peroxidation inhibitory activity and superoxide scavenging activity were used for in vitro antioxidant activity studies. A. panicualta ethanol leaf extract showed the highest phenol and flavonoid contents of 64.82 mg/g and 0.87 mg/g respectively. The highest antibacterial activity was recorded in the ethanol extract with Minimum Inhibitory Concentration...
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Posted by admin on Aug 1, 2011 in |
The aim of this study was to prepare and evaluate poly(ε-caprolactone) (PCL) microspheres containing acetazolamide. Microspheres were prepared by solvent evaporation method. The influence of formulation factors (polymer: drug ratio, aqueous: oil phase ratio, concentration of aqueous phase, stirring speed and stirring time) on morphology, particle size, encapsulation and recovery efficiency were investigated. The microspheres were spherical with a mean diameter of 99.09±1.71μm, the encapsulation efficiency was 75.28±0.97% (w/w) and the recovery efficiency was 88.23±1.06% (w/w). In vitro release studies revealed a controlled release of acetazolamide from PCL microspheres suitable for peroral administration. In conclusion, PCL microspheres containing acetazolamide were successfully prepared by using solvent evaporation method with the selection of appropriate experimental...
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Posted by admin on Aug 1, 2011 in |
The present work deals with development and standardization of phytochemical screening for quantification of ethanolic extract of medicinal plant leaves of Pongamia pinnata Linn. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical evaluation and preliminary phytochemical screening of various successive extracts such as qualitative chemical analysis and HPTLC of extract shows the twelve different peaks confirming that the twelve compounds present in ethanolic extract of Pongamia pinnata. These studies indicated the possible information for correct identification and standardization of this plant...
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Posted by admin on Aug 1, 2011 in |
A validated simple, economic, selective, and stability indicating spectrofluorimetric method was developed for the determination of some antihistaminic H1 receptor antagonist drugs namely ebastine (EBS), cetirizine dihydrochloride (CTZ), and fexofenadine hydrochloride (FXD). The method is based on the reaction of the cited drugs with 2-cyanoacetamide in alkaline medium to give highly fluorescent derivatives measured at 365 nm after excitation at 312 nm. The method was applied for the determination of the studied drugs in their dosage forms. Furthermore, the method was applied for the determination of the drugs in spiked human plasma, and used to reveal the pharmacokinetic characters in a healthy volunteer treated with oral administration of the different dosages of the drugs. The method was utilized to investigate the kinetics of the alkaline, acidic, oxidative, and ultraviolet degradation of the drugs. The apparent first order rate constants and half life times of the degradation products were...
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