Posted by admin on Jul 1, 2011 in |
In the present study, toxicity was developed by oral administration of AFB1 at a dose of (2µg/kg body weight) for 45 days in male mice. Curcuma longa (100 and 200 mg/kg body weight) and Curcumin (50 and 100 mg/kg body weight) were given individually and in combination with AFB1 for 45 days. At the end of 45 days, the blood samples were collected from various groups by heart puncture in eppendroff tubes with anticoagulant for hematological assays. Noncoagulated blood was tested for total erythrocyte count, total leukocyte count, hemoglobin, differential leukocyte count and for other blood indices. The results of present study suggest that Turmeric rhizome powder (Curcuma longa) and Curcumin showed protective effects against AFB1 induced toxicity by modulating red blood cell count, white blood cell count and Hb percentage to some...
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Posted by admin on Jul 1, 2011 in |
Buccholzia coriacea Engle (Capparidaceae ‘wonderful cola’) a tropical plant is used in traditional medicine in the management of diabetes, malaria and hypertension. This study aims to investigate the larvicidal activities of the Petroleum ether, chloroform fractions and methanol extract of B. coriacea seed as a potential agent in vector control for malaria. Third and fourth instar larvae of Anopheles gambiae were used for the study. Five doses (62.5 μg/ml, 125 μg/ml, 250 μg/ml, 500 μg/ml and 1000 μg/ml) of the methanol extract petroleum ether and chloroform fractions tested against the larva with 1% ethanol used as control. The mortality rates were determined 24 and 48 hr after exposure to extract following the WHO procedure. The chloroform fraction exhibited the highest mortality rate of 100% at 250, 500, 1000 μg/ml after 24 hr exposure, the pet ether exhibited mortality rate of 77.5% (1000 μg/ml) after 48 hr exposure while the methanol extract had the lowest effect of 22.5 % after 48 hr. This study reports for the first time the...
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Posted by admin on Jul 1, 2011 in |
The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting starch with di-sodium hydrogen orthophosphate anhydrous at elevated temperatures. It was insoluble in water and has good swelling (400%) property without pasting or gelling when heated in water. Solid dispersions of ritonavir in starch phosphate were prepared by solvent evaporation method employing various weight ratios of drug: starch phosphate such as 2:1(SD-1), 1:1(SD-2), 1:2(SD-3), 1:3(SD-4) and 1:9(SD-5) and were evaluated for dissolution rate and efficiency. All the solid dispersions prepared gave rapid and higher dissolution of ritonavir when compared to pure drug. A 58.34 and 94.41 fold increase in the dissolution rate (K1) of ritonavir was observed with solid dispersions SD-4 and SD-5 respectively. The DE30 was also increased from 6.80%...
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Posted by admin on Jul 1, 2011 in |
The present study carried out to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and antihyperlipidemic (Total cholesterol and triglycerides) effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Stevia rebaudiana leaves. The different fractions of the extract were administered orally as a single dose of 150 mg/kg body weight to alloxan induced hyperglycemic rats and found to reduce blood glucose level significantly (p<0.05). The different fractions resulted in the significant reduction of lipid content which was increased in hyperglycemic rats. The plant fractions also improve the glucose tolerance in the glucose induced rats. The effects of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpines, alkaloids, flavonoids and glycosides etc. were present in the plant which has antidiabetic and hypolipidemic properties. Thus, this investigation paves the way for plant based antihyperglycemic and antihyperlipidemic treatment and indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract...
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Posted by admin on Jun 1, 2011 in |
Lagenaria siceraria is traditionally being used in many countries in the treatment of various diseases including diabetes. The aim of the present study was to evaluate the safety of the methanol extract of L. siceraria aerial parts (MELS) through acute and subchronic toxicity study in mice. For acute toxicity study 500-2000 mg/kg MELS were administered orally and obvious toxic symptoms and mortality was studied upto 72 h. In subchronic study, effect of multiple weekly dosing of 400 mg/kg (one-fifth of the maximum tolerated dose) of MELS was investigated in mice for six weeks and the evaluation was done by the studies of hematological parameters, biochemical estimations of hepatorenal parameters, antioxidant status, and histological observations of the tissue. The extract was found to be well tolerated upto 2g/kg in acute toxicity study. In subchronic toxicity study it showed no significant alteration on any of the parameters, however an improvement in the lipid profile was observed in the treated group of animals. Hence the results suggest that methanol extract of L.siceraria...
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