Posted by admin on Oct 1, 2011 in |
Eclipta prostrata Linn. (Asteraceae) popularly known as “Bhringaraj” is a very useful medicinal plant in India. The aim of the present study is to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Eclipta prostrata. The anti-inflammatory effects were investigated by employing acute inflammatory model; Carrageenan induced paw edema and Sub-acute inflammatory model; formalin induced paw edema in rats. The ethanolic extracts at a dose of 200mg/kg and 400mg/kg body weight showed significant anti inflammatory activity in both the models in a dose dependent...
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Posted by admin on Oct 1, 2011 in |
Liver is a major metabolic organ affected by various toxins and chemicals. So the potential therapeutic agent is needed for the treatment of liver diseases. Natural products are the best source of remedies for the treatment of all diseases.The aim of our study was to investigate the effect of leaf extract of Coccinia indica against Alcohol combines with CCl4 and Paracetamol induced hepatotoxicity.The effects of oral treatment with Coccinia indica (CI) leaf extracts (100mg/kg and 200mg/kg for 7 days) were studied on hepatic damage induced by alcohol (40% alcohol 2.0ml/100g, p.o. for 21 days) and CCl4 (0.1ml/kg, s.c. on 20th day) and also with paracetamol ( 750mg/kg ip.) in rats. Biochemical parameters in serum like glutamate oxaloacetate transaminase (SGOT), total Billirubin (TB), Alkaline phosphatase (ALP) and total proteins (TP) were estimated to assess the liver function. Alcohol – CCl4 and paracetamol treatment produced an increase in SGOT, ALP, Total billirubin and decrease in total proteins indicating the liver damage. These effects were progressively reduced (SGOT, ALP and Total billirubin)...
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Posted by admin on Oct 1, 2011 in |
A simple and cost effective spectrophotometric method is described for the determination of febuxostat in pure form and in pharmaceutical formulations. The drug was highly soluble in methanol so it was selected as the solvent system for the drug. This ensured adequate drug solubility and maximum assay sensitivity. The linearity range for febuxostat at its wavelength of detection of 315 nm was obtained as 0.2–15 µg/ml.The linear regression equation obtained by least square regression method, were Y =0.0802.X + 0.0036, where Y is the absorbance and X is the concentration (in µg/ml) of pure drug solution. The absorbance was found to increase linearly with increasing concentration of febuxostat, which is corroborated by the calculated correlation coefficient value of 0.9999. The limit of detection and limit of quantification was found to be 0.1743 µg/ ml & 0.5281 µg /ml respectively. The validity of the described procedure was assessed. Statistical analysis of the result shows high accuracy and good precision. The proposed method was successfully applied to the determination of febuxostat...
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Posted by admin on Oct 1, 2011 in |
The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl –Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCI-Ethanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity of plant extract was observed in all the models. Pylorus ligation model showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed significant ulcer inhibition in HCl- Ethanol induced ulcer and ulcer protection index in stress induced ulcer. This present study indicates that Heliotropium indicum leaves extract have potential anti ulcer...
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Posted by admin on Oct 1, 2011 in |
Caesalpinia pulcherrima (Linn.) Popularly known as Peacock flower in India belongs to family Caesalpiniace. The objective of the present work was to evaluate the in-vitro antimicrobial potency of the ethanolic and aqueous extract of Caesalpinia pulcherrima (Linn.) flower (CPF) using agar plate disk diffusion method against Escherichia coli, bacillus subtilis and streptococcus aureus. Cephalosporin (5µg/ml) use as a Standard drug. Results were subjected to minimum inhibitory concentration assay by two fold dilution method. Ethanolic extract of Caesalpinia pulcherrima was more effective against Escherichia coli, bacillus subtilis than aqueous extract and cephalosporin. While in case of streptococcus aureus aqueous extract is more effective than ethanolic extract and cephalosporin. Thus, the present study demonstrate that the traditional claim of Caesalpinia pulcherrima (Linn.) flower as an antimicrobial has been confirmed as the aqueous and ethanolic extracts displayed activity against the different microorganism used in...
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