Posted by admin on Jul 31, 2023 in |
The advent of new diseases and the subsequent outbreak of the Covid-19 pandemic has resulted in a tremendous increase in both the production and consumption of antibiotics. While this has helped the economy expand, it has also led to the rise of a problem known as antibiotic resistance. Scientists and researchers worldwide are worried about the spread of antibiotic resistance among various bacterial species. Treating ailments brought on by bacteria resistant to antibiotics is possible through phage treatment. Although phage therapy has shown promise in treating several diseases, it is currently hindered by several obstacles that make widespread use of the technique problematic. We analyze an online survey’s results to better understand the prevalence of antibiotic resistance and phage therapy in human practice and the benefits and downsides of utilizing phages to combat pathogenic...
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Posted by admin on Jul 31, 2023 in |
One of the main causes of mortality around the globe is cancer. Cell division routes increase as cancer progresses, but planned cell death decreases. As a result, cancer is characterized by a variety of these failing systems. The present study used an in-silico approach to examine the ability of sesquiterpene lactones to inhibit the anti-apoptotic proteins Bcl-2 and Bcl-xl. Numerous Bcl-2 inhibitors are undergoing clinical studies. Using PyRx AutodockVina, the phytocompounds were further examined for their in-silico docking interactions. It is interesting to develop novel Bcl-2 inhibitors from phytocompounds such as Arctigenin, Arteminolide C, Gaillardin, Helenalin, and Ixerin D, which have binding affinity scores similar to obatoclax. Potential binding mechanisms within the receptor’s active sites were explored using molecular docking studies of all active substances into the binding sites of Bcl-2 and Bcl-xl, and the physiochemical properties of the phytocompounds were predicted according to Lipinski’s rule of...
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Posted by admin on Jul 31, 2023 in |
Thunbergia grandiflora Roxb. (Mizo local name- Vakohrui or Zawngafian), commonly known as Bengal clockvine, is a long-lived, dicotyledonous plant traditionally used in the state of Mizoram, India for the treatment of cancer, diabetes, eye diseases, cuts and wounds etc. This study aimed to conduct in-vitro, in-vivo anti-inflammatory studies and HPTLC fingerprinting and quantifying the bioactive compounds from Thunbergia grandiflora Roxb. The IC50 value of Egg albumin and BSA denaturation studies was found to be 423.59 µg/ml & 400.76 µg/ml respectively. The results showed that methanolic leaf extract of the plant 200mg/kg b.w. and 400mg/kg b.w. considerably reduced carrageenan-induced paw edema, and their effects were comparable to the standard diclofenac sodium. HPTLC analysis showed the presence of β -Sitosterol in the methanolic extract and the amount of β -sitosterol was found to be 22ng/µl. The identity of the bands of β -Sitosterol in the samples was confirmed by overlapping their UV absorption spectrum with that of the standards. The results for anti-inflammatory studies showed marked anti-inflammatory activity, which was found...
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Posted by admin on Jul 31, 2023 in |
Chickpeas (Phaseolus vulgaris L.) contain various health-promoting bioactive components. Examples: Alkaloids, anthocyanins, catechins, carbohydrates, fibre, flavonoids, phytic acid, quercetin, saponins, steroids, tannins and terpenoids are plant components. Nevertheless, little is known about how these bioactive chemicals function in progressive situations. These results suggest that P. vulgaris seeds could cure metabolic diseases, including diabetes and obesity. This research offers enormous potential for nutraceuticals. Further research is needed to confirm and extend previous findings. Phaseolus vulgaris seeds are also needed in complementary and alternative medicine and pharmaceutical companies. Plant-derived drugs like quinine, artemisinin, digoxin, atropine, strychnine and reserpine have been demonstrated to treat many disorders. Due to their low cost, effectiveness, and safety, traditional medicine and herbal medicines provide the most primary medical care in the world’s poorest countries. Any plant component can produce secondary metabolites or bioactive compounds. Glycosides, tannins, alkaloids, flavonoids, steroids, and triterpenoids have several health benefits. After testing, these plant chemicals are antibacterial, antioxidant, anticancer, and...
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Posted by admin on Jul 31, 2023 in |
Evaluation of drug utilization patterns and cost analysis (direct and indirect) at the dermatology department help to implement guidelines/policy regarding rational prescription and reduce the cost burden on the health care system. The 250 patients’ prescriptions attending the dermatology outpatient department were analyzed using WHO core drug use indicators. Prescribed drugs were classified according to ATC/DDD classification system, the PDD/DDD ratio of drugs was calculated, and direct and indirect costs per encounter were done. The average drug per prescription was 3.3±1, the percentage of drugs prescribed by generic name was 95.52%, the percentage of utilization of scheduled drugs from the National List of Essential Medicines (NLEM) (2022) was 98.79%, the percentage of scheduled drugs from the WHO essential list (2019) was 46.73%. Patient’s care indicators where average consulting time was 7min±1min, average dispensing time was 7min±2min, percentage of drug dispensed was 95.04%, and patient’s knowledge about correct dosage is 10%. Antifungal (26.66%) class of drugs were prescribed maximum followed by antihistaminic (25.42%) in participants. Among prescribed drugs, 41.66% of...
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