Posted by admin on Apr 30, 2023 in |
Traditionally, Croton tiglium seed oil is reported to be very effective for hair loss. Thus, the aim is to study the effectiveness of Croton tiglium with different oils in the treatment of alopecia. The study will help develop the pharmacological profile of herbal formulation, which is being reported scientifically for the first time. The herbal formulations (formulation1, formulation2, formulation3) were formulated by mixing croton oil with olive oil and pure coconut oil. For the primary irritation test, 1 ml quantity of formulations was applied over the respective test sites of one side of the spine. The test sites were observed for erythema and edema for 48 hours after application. A physical parameter study was done for hair length, density, and quantitative histomorphometric studies. Biochemical estimation was done using different biochemical parameters; this oil was applied on shaved skin area of rats for 21 days once a day and hair length, serum total protein, and total testosterone were measured. From observation and results, it can be concluded that all the...
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Posted by admin on Mar 31, 2023 in |
Objective: To investigate the antitumor activity of different extracts (petroleum ether, ethanolic and aqueous extracts) of Taraxacum officinale against DMBA-induced skin cancer in mice. Methods: T. officinale leaves were successively extracted using petroleum ether (PTO), ethanol (ETO) and water (ATO). The antitumor activity was evaluated against DMBA-induced skin cancer in swiss albino mice. The morphological and biochemical parameters were observed inrelation to the skin papilloma. Results: PTO, ETO and ATO were administered at dose of 200 mg/kg body weight, respectively to DMBA-induced skin cancer in mice. All the treatment groups showed a significant (P < 0.05) improvement in all biochemical parameters by restoring to the normal level. The morphological study confirmed that the treatment groups showed a significant reduction in tumor size and the tumor number compared with group II. ETO extract was found to be highly effective against DMBA-induced skin cancer in mice as compared to PTO & ATO groups. Conclusion: The results were significant and confirmed that the T. officinale ETO extract has remarkable antitumor activity against...
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Posted by admin on Mar 31, 2023 in |
A new, precise, economical and gradient reverse-phase high-performance liquid chromatography (RP-HPLC) method has been validated for the relative substance determination in pimecrolimus cream. The chromatographic separation was achieved with phenomenax luna, C18, 150 x 4.6mm and 3 µm particle size column. The flow rate was 1.5 mL/min and eluents were detected at 210 nm using PDA detector. The retention time of pimecrolimus and desmethyl pimecrolimus was found to be 31.5 min and 27.5 min respectively. The calibration curves were linear for both pimecrolimus and desmethyl pimecrolimus. The LOQ was 0.50μg/ ml for pimecrolimus and 0.47μg/ml for desmethyl pimecrolimus. The approach has been validated in accordance with the international conference on harmonization’s regulatory criteria. The evaluated parameters are precision, linearity, detection limit, quantification limit, specificity, accuracy and robustness. The technique may be applied to stability investigations as well as routine analysis to identify and quantify known and unidentified impurities pimecrolimus in the pharmaceutical dosage...
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Posted by admin on Mar 31, 2023 in |
Background: Type 2 diabetes mellitus is increasing very rapidly in India, yet studies regarding knowledge, attitude and practices in diabetes in various Indian communities, especially in the Northeastern region, are limited. It is essential to understand the current gaps in knowledge and problems with the attitude and perceptions of the general population regarding diabetes to effectively plan public health policies. Objective: To assess the knowledge, attitude and practice of type 2 diabetes mellitus (T2DM) patients at Silchar Medical College and Hospital, Silchar, Assam. Materials and Methods: A prospective, cross-sectional, questionnaire-based study was done among 161 patients attending Medicine OPD at Silchar Medical College and Hospital, Silchar, Assam. The study participants were selected using a random sampling method and data were collected through a questionnaire. Results: Out of 161 patients, 66% were male, 34% were female. 70% of the population fell in the 41-60 years age group. 23% of the participants think that diabetes is infectious. 63% of the population believes that insulin is habit-forming and should be avoided. Regular...
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Posted by admin on Mar 31, 2023 in |
The present study aimed to synthesize Carbazole boronic acid derivatives and determine their efficacy in treating breast cancer using the MCF-7 cell line. Nine different derivatives (C1-C12) of boronic acid were prepared i.e. 9-ethyl-(9H-carbazol-3-yl)-boronic acid (C1); (9-benzyl-9H-carbazol-3-yl)-boronic acid (C2); [9-(4-fluorobenzyl)-9H-carbazol-3-yl]-boronic acid (C3); [9-(sec-butyl)-9H-carbazol-3-yl]-boronic acid (C4); (9-pentyl-9H-carbazol-3-yl)-boronic acid (C5); (9-octyl-9H-carbazol-3-yl)-boronic acid (C6); (9-cyclopentyl-9H-carbazol-3-yl)-boronic acid (C7); [9-(4-chlorobenzyl)-9H-carbazol-3-yl)-boronic acid (C8); and [9-(2,4-dichlorobenzyl)-9H-carbazol-3-yl)-boronic acid (C9). Results showed that C3, C7, C8 and C9 exhibited more than 90% inhibition of cancer cell growth in MCF-7 breast cancer cell line. The percentage yield of these compounds was 20%, 26%, 24% and 24%, respectively. However, other compounds have also shown good anticancer properties compared to the control group. Thus, these compounds have shown potential in in-vitro studies and can be used as an anticancer drugs after pre-clinical and clinical...
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