Posted by admin on Oct 1, 2011 in |
Objectives: To develop an integrated industrial production and quality control layout which facilitates the pharmaceutical industries for manufacturing, controlling quality of various types of pharmaceutical formulations in a single production unit. Methods: For designing the integrated process layout for the production and quality control, different operations and their sequences involved in the manufacturing and official tests to be met by various formulations had been considered respectively for achieving an efficient and effective movement of material and people. Results: An ideal integrated industrial process layout for the production and quality control of various pharmaceutical formulations had been developed. Conclusions: In the current marketing trend it is necessary for the manufacturer to shift from single line production layout to multi-product production (integrated) layout to maintain several types of formulations (product mix) to make his presence and sustaining in the market with involvement of...
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Posted by admin on Oct 1, 2011 in |
The purpose of the study was to improve the physicochemical properties of Mesalamine like solubility and dissolution rate by forming solid dispersions with sodium lauryl sulphate (SLS) and Urea (UR) as water-soluble carriers. The solid dispersion of Mesalamine by kneading method were prepared using 1:1, 1:2 and 1:3 ratios of drug to polymer using methanol as solvent. Characterization of Mesalamine solid dispersion was performed by Fourier Transform Infrared (FTIR) spectroscopy and X-ray powder diffractometry study. FTIR spectra reveal that there was no drug – carrier interaction and absence of Mesalamine peaks in XRD profile suggests the transformation of crystalline Mesalamine to amorphous form. The saturation Solubility study was carried out by using flask shaker method at room temperature. Dissolution study was conducted in 0.1N HCl at 37oC ± 0.5oC using USP type II (paddle) type dissolution apparatus. The prepared dispersion showed marked increase the saturation solubility and dissolution rate of Mesalamine than that of drug alone. Therefore the dissolution rate of poorly water soluble drug Mesalamine can be significantly...
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Posted by admin on Oct 1, 2011 in |
Optically active 1, 5- benzothiazepines belong to the well known benzothiazepine type substances. Some of them possess important bioactivities. In this article, optically active 2, 3-dihydro-1, 5-benzothiazepine derivatives are synthesized by the reaction of new α-β unsaturated carbonyl compounds with 2-aminothiophenol under mild conditions in the presence of silver sulphate in acetonitrile in short reaction time with excellent yield. The structures of newly synthesized compounds were confirmed by spectral evidence and the compounds were evaluated for their anti-bacterial and antifungal activity. All synthesized compounds have shown excellent...
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Posted by admin on Oct 1, 2011 in |
The free radical scavenging potential of blue green algae spirulina platensis (Oscillatoriaceae) was studied by different antioxidant models. Free radicals are implicated for more than 80 diseases including Diabetes mellitus, arthritis, cancer, ageing etc. In the treatment of theses diseases, antioxidant therapy has gained an utmost importance. Current research is directed towards finding naturally occurring antioxidant of plant origin. In Indian system of medicine, blue green algae spirulina platensis is an important medicinal plant and it has been used in various ailments and as health tonic. To understand the mechanisms of pharmacological actions, the in vitro antioxidant activity of ethanolic extract of spirulina platensis was investigated for the activity of scavenging DPPH radical, nitric oxide radical. In all the testing, a significant correlation existed between concentrations of the extract and percentage inhibition of free radicals. These results clearly indicate that blue green algae spirulina platensis is effective against free radical mediated diseases. The data suggests that the extract contains compounds may be effectively utilized as a wide spectrum of...
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Posted by admin on Oct 1, 2011 in |
Primary spinal cord presentation of Primitive neuroectodermal tumors (PNET) is a rare occurrence and carries poor prognosis. A 13-year-old boy presented with pain in neck region, bilateral upper and lower limb weakness and bladder and bowel dysfunction. Neurological examination revealed the marked paresis with hyporeflexia of both the upper and lower extremities. Preoperative MRI of spine revealed an intradural mass at the C2-C5 level. A laminectomy of C2-C5 vertebra level and near total removal of the tumor was performed. Pathological findings were consistent with PNET. Chemotherapy along with radiotherapy was started and good response was observed. The clinical, histopathologic, and radiologic findings of the patient are...
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