Posted by admin on Jun 30, 2023 in |
Herbs, which have been used to cure numerous ailments since ancient times, play an important role in building the foundation of modern medications. The present study aimed to investigate the antioxidant potential of nutraceutical dry powder suspension formulated with Moringa oleifera leaves and Celastrus paniculatus seeds extract against DPPH (2,2-diphenyl-1-picryl-hydrazine-hydrate). Plant extracts are prepared using ethanol as a solvent in the Soxhlet apparatus and extracts are evaluated for antioxidant activity using ascorbic acid as standard and best % inhibition of free radicals the dose is selected for formulation. Further evaluation studies are carried out for all the batches to finalize the optimized batch showing good flow properties and drug release profile. Both plant extracts showed good % Radical scavenging activity (%RSA) compared to ascorbic acid’s scavenging activity. The optimized formulation showed acceptable evaluation results, including pH, angle of repose, carr’s index, hausner ratio, sedimentation volume, redispersibility, viscosity and drug release. The formulated dry powder suspension formulation showed good antioxidant activity. Thus, the present investigation revealed that the developed nutraceutical...
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Posted by admin on Jun 30, 2023 in |
Hordeum vulgare (Barley) grass is the best functional food for providing nutrition and eliminating toxins from human cells; however, its functional ingredients have also played an important role in health benefits. Flavonoids, saponarin, lutonarin, K, Ca, Se, dietary fiber, polysaccharide, alkaloid, glycoside, tannin, metallothionein and polyphenols are all found in barley grass. Microscopical studies showed that stomata, epidermal cells and trichomes were conducted as part of a pharmacognostic investigation of the grass of H. vulgare. The qualitative assays were done to predict the presence of phenols, tannin and flavonoid content. The Minimum inhibitory concentration (MIC) method was used to screen H. vulgare leaf extract for antimicrobial potential against S. typhi, S. aureus, B. subtilis and E. coli and chloramphenicol was used as a standard. Amongst all the extracts, the chloroform extract of H. vulgare was found to be more effective as its MIC value is almost equal to the standard antibiotic...
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Posted by admin on Jun 30, 2023 in |
Antibiotic yield has been raised by numerous pharmaceutical firms in response to the rising population, the COVID-19 outbreak, and the introduction of several new diseases. Several heavy metals are used in the antibiotics’ formulation. The release of antibiotics and heavy metal ions has wreaked havoc on the ecosystem. The issue with heavy metals is that the bulk of them last a long time in the environment and are a leading cause of different types of cancer and other human diseases. On the other hand, experts worldwide are concerned about the presence of antibiotics in the environment, particularly in wastewater, because it leads to the emergence of antibiotic-resistant microorganisms (superbugs) that can cause widespread damage. Bioremediation is a viable approach for treating pharmaceutical industry wastewater with antibiotics and heavy metal ions. Copper, cadmium, nickel, zinc, lead and iron are common heavy metal ions found in wastewater from antibiotic-producing pharmaceutical firms. Along with it, antibiotics like chlortetracycline, oxytetracycline, cefalexin, Sulfamethoxazole, norfloxacin and ciprofloxacin are frequently found in the effluent of pharmaceutical...
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Posted by admin on Jun 30, 2023 in |
Introduction: The aim was this trial is to assess to evaluate the effect of “Chaturjatadi Sambharaka” in the management of malnutrition in Children. Material and methods: This research work was done in two phases. Phase one included demographic study and in phase two was clinical study. A Randomized open label-controlled trial was conducted on100 undernourished children of 1-10 years of age group. Total cases were divided into two groups (50 in each). In Group A, only Nutritional Rehabilitation (As per ICMR guidelines) was administered whereas in Group B, Nutritional Rehabilitation (As per ICMR guidelines) along with the trial drug Chaturjatadi Sambharaka was administered. The trial drug was administered in Avleha form in a dose 180-200 mg/kg/day in divided dose or 8 weeks and post follow up was done after month. Scoring of chief clinical features was done before and after treatment. Result: The clinical efficacy of the drug was analysed statistically on all parameters mentioned in the Assessment criteria. Both groups, showed statistically significant (P<0.001) improvement on anthropometric parameters-...
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Posted by admin on Jun 30, 2023 in |
Clove oil is an essential oil made from the plant, Szygium aromaticum. It is commonly used to help ease digestive issues, relieve pain, and support respiratory conditions. This work aims to determine at what temperature sublingual films are formed most effectively during process. The given temperature batches were manufactured at 75 °C, 80 °C, 85 °C, 90 °C. The sublingual films were prepared by using the solvent casting method, and the materials used, such as Hydroxypropyl methylcellulose E5, and different grades of polyox were previously optimized. The various batches at different temperatures went through characterization regarding the viscosity of the solution before casting as well as film weight and thickness after casting. All other samples used were of 21 mm x 25 mm film. With these given film samples from each batch, surface pH, swelling index, folding endurance, tensile strength, disintegration time, and percent moisture were all tested. Thus, this study showed the optimum temperature for fast-dissolving sublingual films of clove oil to improve bioavailability and ease of...
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