A number of aldehydes were reacted with acetyl acetone or ethyl acetoacetate and urea under Biginelli reaction conditions to give the corresponding 5-acyl-4-(substituted-aryl)-6-methyl-3,4-dihydropyrimidin-2-one. The 5-acetyl-derivatives were converted into pyrimido-oxazoles, pyrimido-pyrazoles, and chalcones. Some Mannich bases were also synthesized. Some selected compounds were tested for their antimicrobial...
Read MoreThe plant of Baliospermum montanum (Willd.) was shaded dried, and then these were made into coarsely powdered by using dry grinder. The powdered roots of the plant (200gm) was packed in soxhlet apparatus and continuously extracted with petroleum ether (40-600C) till complete extraction. After completion of extraction, the solvent was removed by distillation and then concentrated extract obtained was dried under reduced pressure using rotatory evaporator at temperature not exceeding 400C and then moderate heating on water bath. A dark brown extract approximate 2 gm. was obtained. From the drug petroleum ether was removed and the defatted drug was extracted with ethanol (95%) till complete extraction, after completion of extraction the solvent was removed by distillation and then concentrated extract obtained dried under reduced pressure at temperature not exceeding 400C and then give moderate heating on water bath. The ethanol extract obtained was dark brown in color weighed about 18gm. The ethanolic extract was kept in petri dish and it was stored in desiccators at cool...
Read MoreThe plant Sesbania grandiflora (L.) Pers is reported to have great medicinal value in Indian medicine. Sesbania grandiflora, commonly known as “sesbania” and “agathi,” is widely used in Indian traditional medicine for the treatment of a broad spectrum of diseases. Sesbania grandiflora is a fast-growing tree with a typical adult height of between 3 and 5 m. The leaves are regular and rounded and the flowers are white and large, very characteristic. The fruits look like flat, long and thin green beans, belongs to the family Fabaceae under the subfamily Faboideae. It is believed to have originated either in India or Southeast Asia and grows primarily in hot and humid tropical areas of the world. The chemical constituents found are galactomannans, linoleic acids, β- Sitosterol and carbohydrates. The microscopic examination of crude drug aims at determination of the chemical nature of the cell wall along with the determination of the form and chemical nature of the cell contents. Thus it determines the size, shape and relative structure of the...
Read MoreThe effect of different percentages of a hydrophilic polymer and impact of granulation technique on the release profile of gliclazide from matrix system was investigated. Matrix tablets of Gliclazide were prepared by both direct compression and wet granulation process using METHOCEL K15M CR. Release kinetics of Gliclazide matrix tablets were determined using USP paddle method at Phosphate buffer (pH 7.4) and conducting for 10 hours. Statistically significant differences were found among the drug release profile from different polymeric concentration and granulation process. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer model. It’s found that at lower concentration of polymer (15%) most of the formulation tends to Higuchi release kinetics and at higher concentration (30%) best fit with Zero order release kinetics. Higher polymeric content (30%) in the matrix decreased the rate of the drug due to increased tortuosity and decreased porosity. At lower polymeric level (15%) the rate of drug release was elevated. In this study effect of granulation process on drug...
Read MoreA number of aldehydes were reacted with acetyl acetone or ethyl acetoacetate and urea under Biginelli reaction conditions to give the corresponding 5-acyl-4-(substituted-aryl)-6-methyl-3,4-dihydropyrimidin-2-one. The 5-acetyl-derivatives were converted into pyrimido-oxazoles, pyrimido-pyrazoles, and chalcones. Some Mannich bases were also synthesized. Some selected compounds were tested for their antimicrobial...
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