Posted by admin on Apr 1, 2011 in |
Many chemo prophylactic approaches to manage or prevent opportunistic infections using many drugs have been reported. Based on the reported cases of chemo prophylactic approaches to manage opportunistic infections, the effect of Cotrimoxazole on HIV patients was studied. Seventy two patients with CD4+ cell counts ≤ 350cells/µl were recruited for the study. Each patient received cotrimoxazole two single strength tablets (2 x 480mg) three times a week. The patients were followed for a period of six months during which time data was collected at month 1, month 3 and month 6. The results showed that dermatological, gastrointestinal and respiratory as well as other bacterial related infections were considerably reduced in these patients during the six month period of the study. Being a drug that is cheap, readily available and not requiring any special storage and handling conditions, cotrimoxazole could be considered as a good prophylactic agent in the management of HIV/AIDS disease in resource limited settings such as...
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Posted by admin on Apr 1, 2011 in |
The seeds and leaves of Ficus racemosa have shown considerable antioxidant and cytotoxicity properties while their antibacterial activities were found low. The extracts were found to have different levels of antioxidant and cytotoxicity properties in different concentration. For antioxidant activity, here we used free radial scavenging activity of plant extracts against stable DPPH (1, 1-diphenyl 2-picrylhydrazyl) which was determined spectrophotometrically by the method described in Brand William et al., (1995). Methanolic extracts of these plants were used. As we know that ascorbic acid is a perfect antioxidant, that’s why it was used as a standard reference. The absorbance was taken at 517nm by UV spectrophotometer. The IC50 (Inhibitory Concentration) value of standard was 8.287µg/ml. The IC50 value of Ficus racemosa seeds and leaves were 3.893µg/ml and 14.5µg/ml respectively. For Cytotoxicity, brine shrimp lethality bioassay was used. We used Vincristine sulfate as a standard reference. The LC50 value of standard was 0.057µg/ml. The LC50 (Lethal Concentration) value of the seeds and leaves were 0.56µg/ml and 0.467µg/ml respectively. The plant has...
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Posted by admin on Apr 1, 2011 in |
Hepatitis is major health problem in human being due to various chemical including therapeutic agent and environmental toxin and this can leads to illness like jaundice, which sometime may lead to even death. Ipomoea digitata Linn. is used in ayurvedic formulation for various disease conditions and commonly known as “Vidarikanda”. The present study deals with hepatoprotective activity hydroethanolic extract of tuberous root of Ipomoea digitata Linn. against CCl4 (i.p) induced liver damaged in female Wister rat. The drug was extracted and preliminary phytochemical screening of extract was done then extract was subjected to toxicity study. The hydroethanolic extract of tuberous root of Ipomoea digitata Linn. was administered orally at the dose of 250mg/kg and 500mg/kg .These shows significant protective effect on liver evidenced by lowering serum level of ALT, AST, ALKP, TB, DB, and Serum Triglyceride and also by histopathological study. All result obtain result are compared with standard (Silymarin) and control group. Thus it concludes that hydroethanolic extract of Ipomoea digitata Linn. shows significant hepatoprotective activity prevents chemically...
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Posted by admin on Apr 1, 2011 in |
Adrenal myelolipomas are rare benign endocrinologically inactive tumor composed of mature adipose tissue and hematopoietic cells in varying proportions. Most lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. Its characteristic appearance on sonography and computed tomography enables preoperative diagnosis with a high degree of safety and accuracy. The association of adrenal myelolipoma with cholelithiasis is not well documented in the literature. It could be an incidental association or there may be a common underlying pathologic basis. Here we report a rare case of adrenal myelolipoma in a 30-year old woman. Our case was unusual because of large size, symptomatic presentation and associated gall...
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Posted by admin on Apr 1, 2011 in |
Aerial parts of Ruellia prostrata were subjected to extraction and further fractionation to obtain antioxidant rich fraction. Different concentrations of methanolic extract and its n-butanolic fraction were subjected to antioxidant assay by DPPH method, Nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models. IC50 values for methanolic extract and its n-butanolic fraction were found to be 137.89±5.74 and 42.25±3.17 respectively in comparison to L-Ascorbic acid and Rutin as standard with IC50 values of 6.537±0.235 and 5.437±0.206 respectively, in DPPH model. In nitric oxide scavenging activity the IC50 values were found to be 152.22±6.37 and 67.70±2.29, 21.06±0.953 and 29.93±0.324 for methanolic extract and its n-butanolic fraction, L-Ascorbic acid and Rutin respectively. The fractions showed good reducing power with increasing concentration. However, the n-butanolic fraction showed a good reducing power and better free radical scavenging activity as compared to methanolic extract thus its antioxidant potential is comparable to standards. The phytochemical screenings confirm the presence of triterpenoids glycosides and...
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