Posted by admin on Feb 1, 2011 in |
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range. Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to a wet mass and passed through 20# sieve in order to obtain granules. These granules were air dried and passed through 30# sieve. These dried granules were lubricated with Magnesium stearate, which was previously passed through 60# Sieve and then punched using single punching machine. Results: Pre-compression character such as compressibility index, angle of repose and Post-compressional characteristics such as weight variation, hardness, diameter, thickness, friability were found to be with in the I.P limits. In vitro release profile was studied using HPMC K4M, HPMC K 100M and methocel E50 LV at three different concentration. The percentage cumulative amount of drug...
Read More
Posted by admin on Feb 1, 2011 in |
The study was obtained to develop oral controlled release matrix tablets of Lamivudine having different proportion of Guar gum (retardant polymer) and to study the effect of formulation factor such as polymer proportion on the in- vitro release. The prepared granules were evaluated such as angle of repose, loose bulk density, tapped bulk density and compressibility index and satisfactory results were obtained. Compressed tablets were also evaluated for uniformity of weight, content of active ingredient, thickness, friability, hardness, swelling, erosion behaviour and in-vitro dissolution studies. All the formulations showed good results which were compliance with Pharmacopoeial standards. In-vitro drug release studies were carried out using USP XXII dissolution apparatus type II at 50 rpm with 900 ml phosphate buffer solutions (PBS) of pH 6.8, maintained at 37±0.50C. The release kinetics was analyzed using the zero-order, first-order model equation, Higuchi’s square-root equation, and the Korsmeyer-peppas model. In vitro release studies revealed that the release rate decreased with increases in polymer proportion. Matrix tablets containing 15% guar gum (Formulation F2) were...
Read More
Posted by admin on Feb 1, 2011 in |
Purpose: Ciprofloxacin, an antibacterial agent, is having low solubility in aqueous solution and high rate of absorption from the stomach. It is precipitated at alkaline pH which leads to erratic absorption of the drug from small intestine. To overcome these difficulties, many researchers have prepared different formulations of Ciprofloxacin. But till now very few formulations are available from which the drug is absorbed uniformly, so that safe and effective blood level of Ciprofloxacin can be maintained for a prolonged period. To fulfill this requirement, in the present study, a sustained release drug delivery system (hydrogel) has been designed and chemical interaction between Ciprofloxacin and polymer in hydrogel has been studied by FTIR and Raman Spectroscopy. Methods: Ultrasonication method was used for preparation of hydrogel of the Ciprofloxacin, taking Carbopol 934 polymer with drug to polymer weight ratio 1:5. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were carried out and spectra were used for interpretation. Results: From the spectral interpretation, it...
Read More
Posted by admin on Feb 1, 2011 in |
The present study was aimed to evaluate total antioxidant capacities of eleven different commonly consumed aqueous fruit extracts viz. Ananas comosus, Artocarpus heterophyllus, Carica papaya, Citrullus vulgaris, Citrus sinensis, Malus domestica, Manilkara zapota, Musa paradisiaca, Phyllanthus emblica, Psidium guajava and Pyrus communis. The total antioxidant capacity was assessed using phosphomolybdenum method at different concentrations. Total antioxidant capacity was found to be highest in Phyllanthus emblica (197.5μg of ascorbic acid/mg extract) and lowest in Artocarpus heterophyllus (1μg of ascorbic acid/mg extract). The present research programme underlies the total antioxidant potentials of...
Read More
Posted by admin on Feb 1, 2011 in |
Chlorpyrifos (CPF) an Organophosphate insecticide was evaluated for its toxicity to produce reproductive disorders in rats following oral exposure. In the present study CPF was given to the mice at the dose levels of 10 and 20mg/kg body weight by Gavage method. A histological alteration of ovary and uterus was examined under light microscope. Its oxidative stress levels were studied by noting lipid peroxidation levels and hormonal changes (FSH) were also checked to evaluate the fertility rate in CPF induces toxicity mice. LD50 CPF was established for Swiss albino mice. Bioremediation was done to toxic induced mice using crude and extracted curcumin at 100 and 200 mg/kg body weight respectively. In control group, the germinal epithelium was continuous with prominent and well defined different stages of graffian follicles. On the other hand chlorpyrifos (CPF) treated group showed ruptured germinal epithelium with multiple nuclei and matured graffian follicles with degenerated ovum. Corpus leutium cells were observed to be rudimentary. Unusual number of vacuolated spaces was observed in ovarian cortex. Thus,...
Read More
