Posted by admin on Mar 1, 2011 in |
The aim of the present investigation was to evaluate the antimicrobial efficacy of methanolic extract of whole plant of Nelumbo nucifera Gaertn. The methanolic extract of Nelumbo nucifera were tested for antibacterial efficacy against three gram positive bacteria & three gram negative bacteria and antifungal activity against three fungal strains by disc diffusion method. In present study Ciprofloxacin 100 mcg/ml (antibacterial) and Ketakonazole 100 mcg/ml (antifungal) used as a reference standard. The methanolic extract of Nelumbo nucifera at the concentration of 150mcg/ml were found significant antimicrobial activity against the entire organism was tested. This study scientifically supports the usage of whole plant as a remedy for various superficial bacterial and fungal infections in traditional...
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Posted by admin on Mar 1, 2011 in |
Mucoadhesive microcapsules of verapamil, a peripheral vasodilator, used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, have been prepared from sodium alginate, hydroxypropylmethyl cellulose- K4M & E5LV, Carbopol 934P using 10% w/v calcium chloride solution by ionic gelation method. Drug : polymer ratio was 1:1 in all formulations and polymer mixtures employed were 1:1, 2:1, 3:1, 4:1 of sodium alginate: polymer (hydroxypropyl methyl cellulose- K4M & E5LV, carbopol 934P). Calcium chloride was used for ionic gelatin and cross linking of sodium alginate molecules. Microcapsules were spherical in shape and of sizes between 580 microns to 831 microns. Carbopol 934P was found most effective in controlling drug release from microcapsules followed by hydroxypropyl methyl cellulose- K4M. Drug releases from the best formulations of carbopol 934P and hydroxypropyl methyl cellulose-K4M follow anomalous...
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Posted by admin on Mar 1, 2011 in |
The aqueous, methanolic and saponin extracts of Zizyphus mauritiana barks has been screened for antimicrobial activities against some human vaginal pathogens Staphylococcus aureus, Pseudomonas aeruginosa, streptococcus facecalis, klebsiella pneumoniae, Escherichia coli, Enterobacter faecalis, Enterobacter faecium and Proteus mirabilis isolated from patient samples. Extracts were found to produce significant inhibition against all the pathogens. Saponin extract were observed to be more active than methanolic and aqueous fraction. Extracts are found to be more active against Staphylococcus aureus and Escherichia coli...
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Posted by admin on Mar 1, 2011 in |
Tinospora cordifolia, belonging to the Menispermaceae family, has been investigated for isolation of its secondary metabolites and evaluation of biological activities with special emphasis to the antimicrobial screening and cytotoxic study. The crude methanolic extract of Tinospora cordifolia along with its Pet ether, carbon tetrachloride, and chloroform soluble fractions were subjected to microbiological investigation by the disk diffusion method. The CCl4 soluble fraction was found to have mild to moderate anti-microbial action. In the brine shrimp lethality bioassay, the Pet ether, CCl4, chloroform and aqueous soluble fractions of crude methanolic extract were found to show LC50 1.918 mg/ml, 0.402mg/ml, 0.691 mg/ml and 2.246 mg/ml respectively. This indicated that the carbon tetrachloride and chloroform fractions were highly cytotoxic....
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Posted by admin on Mar 1, 2011 in |
Diabetes mellitus is characterized by persistent fasting and postprandial blood glucose levels due to inability of the body cells to utilize glucose properly. Though drugs are plenty for the treatment of diabetes, none is found to be ideal due to undesirable side effects and diminution after prolonged use. Hence, search for novel drugs, especially from plant origin continues. Based on folkloric use, the present study was designed to evaluate the antidiabetic and antioxidant potential of Annona squamosa Linn. (Annonaceae) in STZ-induced experimental diabetes in rats. Daily oral administration of Annona squamosa leaves extract (100 mg/kg b.w./day) to diabetic rats for 30 days significantly reduced the levels of blood glucose, glycosylated hemoglobin, urea and creatinine. The observed decrease in the levels of plasma protein, plasma insulin, C-peptide and hemoglobin in the diabetic rats were elevated to near normal by the extract treatment. The altered antioxidant status of diabetic rats were reverted back to near normalcy by the administration of Annona squamosa leaves extract. The efficacy of the Annona squamosa extract...
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