Posted by admin on Jun 1, 2011 in |
Mallotus tetracoccus (Roxb.) Kurz. is found in Western Ghats of India. Mallotus tetracoccus is one of the medicinally important plants belonging to the family Euphorbiaceae, commonly known as “vatta kanni” in Tamil. In the present study the ethanolic extract of Mallotus tetracoccus has been subjected to GC-MS analysis. The major chemical constituents are Bis (2-ethyl hexyl) phthalate (46.78%), 3-methyl-2-(2-oxypropyl) furan (13.31%), E-8-methyl-9-tetradecen-1-ol acetate (6.63%), Octadecanoic acid, 2-oxo (4.46%) and Longiborneol (2.39%). Thus the extract of Mallotus tetracoccus was characterized by substantial levels of diesters (50%), alcohols (15%), alkanes (3%), sesquiterpenes (5%), terpenoids (13%), fattyacid (5%) and sugars (2.6%). The presence of some of these constituents in the plant extract provides the scientific evidences for the antipyretic, anti-inflammatory and hepatoprotective properties of the...
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Posted by admin on Jun 1, 2011 in |
The methanol extract of the stem bark of Anogeissus leiocarpus was evaluated in vivo at 2.5mg/kg for antioxidant, hepatoprotective and ameliorative effect on hepatocellular injury following pre-treatment or post-treatment with carbon tetrachloride (CCl4). Levels of the lipid peroxidation product, malondialdehyde (MDA) or thiobarbituric reactive substances (TBARS) were taken as a measure of oxidative stress, while levels of biochemical such as aspartate aminotransferase, alanine aminotransferase and bilirubin (total and conjugated) were taken as biomarkers of liver damage. Irrespective of whether the animals were pre- or post- treated with Anogeissus leiocarpus, there was no statistical difference between the levels of MDA and markers of liver damage in the groups on A. Leiocarpus + CCL4 group and Vitamin E + CCl4, although both were significantly (P<0.05) lower than in the group on CCL4 only. However, malondialdehyde (MDA) levels in the heart, and to some extent, in the kidney, were hardly influenced by the treatments. These results indicate that methanolic extract of the stem bark of Anogeissus leiocarpus possess antioxidant, hepatoprotective and ameliorative...
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Posted by admin on Jun 1, 2011 in |
The present work carried out the study to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Brassica oleracea. The different fractions of the extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced as well as glucose induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). The different fractions of Brassica oleracea to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 49% in diabetic control. The plant fractions also improve the glucose tolerance in the glucose induced rats. The effects of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpenes, alkaloids and flavonoids etc. were present in the plant which has antidiabetic and glycogenesis properties. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions...
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Posted by admin on Jun 1, 2011 in |
Premna integrifolia Linn. (Family: Verbenaceae) is a medicinal plant which is traditionally used against a number of diseases including inflammatory condition. On the scientific basis of traditional uses, the ethanolic extract of leaves of Premna integrifolia Linn. was assessed for its possible analgesic and antimicrobial activity. The analgesic activity of the sample was studied using acetic acid induced writhing model in mice. Antibacterial activity of leaves of Premna integrifolia Linn. was tested by using the disc diffusion method. In analgesic activity, the extract produced 52.17% (p<0.01) acetic acid induced writhing inhibition in mice at the dose of 500 mg/kg body weight, which is comparable to diclofenac sodium 65.21% (p<0.01) at the dose of 25 mg/kg body weight. The extract showed significant antibacterial activity against both gram positive and gram negative bacteria. All the results tend to justify the traditional uses of the plant and require further investigation to identify the chemicals responsible for these...
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Posted by admin on Jun 1, 2011 in |
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method against Gram-positive bacterial strains (Bacillus subtillis, Staphylococcus aureus) Gram-negative bacterial strains (Pseudomonas aerugenosa, Kleibsella pneumonia) and fungal strains (Aspergillus niger, Candida albicans). The analogues 1b, 1h and 1i showed promising antimicrobial activity against gram-negative Kleibsella pneumonia; where as analogues 1b, 1e, 1g and 1h showed promising antifungal activity against Candida...
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