In the present study a new series of coumarin derivatives have been synthesized by condensation of ethyl acetoacetate and resorcinol. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR and Mass spectral analysis. These compounds were screened for their Analgesic and Anti-inflammatory activities. Among the synthesized compounds II (a-1 to...
Read MoreThe study was undertaken to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of methanolic extract of Momordica charantia. The different fractions of the extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced as well as glucose induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). The different fractions of Momordica charantia to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 50.60% in diabetic control. The plant fractions also improve the glucose tolerance in the glucose induced rats. The effects of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpines, alkaloids and flavonoids etc. were present in the plant which has antidiabetic and glycogenesis properties. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions (Petroleum ether, ethyl...
Read MoreThe direct delivery of therapeutically active drug to the pulmonary tract has proved to be a life saving tool for many Asthmatics. Salbutamol being a drug of choice in severe Asthma attacks, in the present study attempt was made to prepare MDI of Salbutamol in suspension formulation and compare it with the marketed MDI of salbutamol suspension. The proportion of C.F.C. propellant blend (p11 & p12) in 30:70 proportion gave optimum vapor pressure; in the range of 70-75 psig was selected. Oleic acid was selected as a surfactant and its concentration was optimized. A series of physicochemical tests were performed simultaneously on both the preparations. Results were compared. The formulations were further subjected to in-vitro evaluation whereby net respirable fraction was determined. Logic behind this study was to create a better suspension than that available in the market. In all qualitative as well as quantitative tests the formulated suspension was comparable with marketed MDI. However our formulation retained minimum amount of drug (8.57%) on adaptor compared to the marketed...
Read MoreThe purpose of this research was to improve the granulation efficiency and the final granule characteristics for the any kind of the material that is to be granulated via FBG process. The fluid bed granulation process is an influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature etc. These process variables largely affect the granulation efficiency and the final granule characteristics. The effect of starting materials on granule properties was previously studied. The aqueous solution of 5% PVP K-30 was used as a binder and sprayed on lactose monohydrate bed. A full factorial design was applied to optimized the granulation process variables like inlet air temperature, spray rate and batch size and other granule properties, namely the Carr’s index, Hausner index, the angle of repose and the moisture content, were evaluated at the optimal operation conditions. Granules prepared by this technology have good flow property, good compressibility; and good flow ability with a proper adjustment of process variables. So FBG technique has its own...
Read MoreCasein microparticles cross linked with glutaraldehyde were prepared by steric stabilization process and the controlled release of drug from the particles were evaluated in-vitro. Casein is a natural biopolymer present abundantly in milk is utilized because of its biocompatibility through oral route. Methotrexate loaded Casein microparticles of size 0.5 to 5 µm were prepared. The release of methotrexate from the casein microparticles were evaluated in simulated gastric and intestinal fluids in-vitro. The coating of the particles with Eudragit L 100 made them as pH sensitive and therefore we found a significant release in the intestinal pH. The particles were resistant to proteolytic activity which can increase the durability of the particles in the intestine. This study demonstrates that the casein microparticles can be made pH sensitive and it can be successfully used as a targeted delivery system....
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