Posted by admin on Feb 1, 2011 in |
The present work describes new spectrophotometeric methods for the assay of four drugs namely Meropenem (MPN), Cefditoren Pivoxil (CTP), Mesalamine (MSL) and Cefdinir (CDN) in both pure form and Pharmaceutical formulations. All methods involve the oxidative coupling reaction of MPN, CTP, MSL and CDN with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in presence of Fe(III) in an acidic medium to form colored products with absorption maxima at 620, 630, 500 and 620 nm respectively. Beer’s law was obeyed in the ranges of 5-25, 5-40, 5-25 and 2-12 µg/ml for MPN-MBTH, CTP-MBTH, MSL-MBTH and CDN-MBTH respectively. Statistical treatment of the experimental results indicates that the methods are precise and accurate. The proposed methods have been applied to the determination of the active components in commercial formulations with no interference from excipients. A comparative study between the suggested procedures and reference procedure for these compounds in the commercial formulations showed no significant difference between two...
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Posted by admin on Feb 1, 2011 in |
Plants have traditionally provided a source of hope for novel drug compounds, as plant herbal mixtures have made large contributions to human health and well-being. We report in this work for the first time, the potent antibacterial activity of Punica granatum and its wild form daru. Ethanol, petroleum ether and distilled water extract of fruit’s white membrane were screened for in vitro activity against four dental bacteria- Streptococcus sp., Lactobacillus sp., Staphylococcus sp. and Proteus sp. This plant was selected due to its traditional use for the treatment of oral infections. Among three tested extracts ethanol extract was the most effective against all the four dental...
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Posted by admin on Feb 1, 2011 in |
The purpose of the study was to determine the in vitro as well in vivo efficiencies of 1% carbopol hydrogel different preparations containing the meloxicam, a cyclooxygenase-2 inhibitor anti-inflammatory drug with b-cyclodextrin. The release of plain drug was then compared with release of from trans dermal gel containing physical mixture of drug and b-cyclodextrin, inclusion complex of drug and b-cyclodextrin obtained by kneading method and in situ complex of drug and b-cyclodextrin obtained by reacting the drug and b-cyclodextrin within the gel. All solid inclusion complex abstained were then characterized by x-ray diffractrometry, infrared spectroscopy, differential scanning colorimetry and scanning electron microscopy, where as the in situ complex formation was evidenced only by release and permeation studies. Although many other derivative of cyclodextrins such as hydroxy propyl-b-cyclodextrin and methylated-b-cyclodextrin are better skin permeating enhancers but in this study b-cyclodextrin was employed because of ease of availability and low cost. Solid inclusion complex was prepared by kneading method. Gel formulations were prepared by incorporating pure drug, physical mixture, inclusion complex...
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Posted by admin on Feb 1, 2011 in |
New 5- phenyl- 1, 3, 4- oxadiazole- 2- thiol derivative was synthesized by the ring closure reactions of benzohydrazides with carbon disulphide in presence of ethanolic KOH followed by substitution with secondary amines at 2nd position. All the newly synthesized compounds were characterized by IR, NMR and LC-MASS spectral data. Most of them were tested for their anti-inflammatory and antibacterial...
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Posted by admin on Feb 1, 2011 in |
Hormonal changes during the menstrual cycle are well documented but there are very few reports on the changes in serum calcium, phosphorus and uric acid levels in various phases of the menstrual cycle. Therefore, present study was conducted on 50 healthy females in the age group of 18-35 menstruating regularly (cycle length between 25 and 35 days). The study demonstrated that serum calcium levels were significantly (p<0.001) higher in follicular phase than menstrual and luteal phases. Serum inorganic phosphorus levels decreased progressively and significantly (p<0.001) from the menstrual phase to the follicular phase and from the follicular phase to the luteal phase while serum uric acid levels were significantly (p<0.001) lower in luteal phase than the menstrual and follicular phases. These changes in calcium, phosphorus and uric acid in serum may have significance in terms of the normal reference interval, hence necessitate small but significant alterations to the normal reference interval for these analytes in menstruating...
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