Posted by admin on Sep 1, 2010 in |
Medicinal plants are important source of potentially useful structures for the development of novel chemotherapeutic agents. The present study was aimed to evaluate the antifungal effect of partially purified C. gigantea latex extract on some human pathogenic fungi. Ethanolic extract of the latex were tested in vitro against fungi strains. The inhibitory effect was assessed by disc diffusion method. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were also determined by serial dilution method. The ethanolic extract was subjected to qualitative phytochemical screening for the presence of bioactive ingredients. The ethanolic extract shows the presence of many biologically active molecules such as flavonoids, alkaloids, triterpenoids, steroids, saponins, phenols and glycosides. The latex extract shows significant zone of inhibition in dose dependent manner. The MIC and MFC values of latex extract against fungal strains varies from 1 mg to 8 mg and the results are comparable with Amphotericin B. From this study, we conclude that the latex extract possesses potent fungicidal activity which may be due to the...
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Posted by admin on Sep 1, 2010 in |
Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β- cytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants leaves of Caesalpinia bonducella, Mucona puriens, Pongamia pinnata. The extracts were prepared by continous hot soxhlet extraction using petroleum ether and water. Conclusion: The study reveals that the polyherbal formulations have antidiabetic activity and the action may be due to the restoration or regeneration of β-cells of...
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Posted by admin on Sep 1, 2010 in |
The optimization of this study is biochemical effect of protein in Liver, Kidney, Uterus and Ovary of albino rats (Sprague-dawley strain) weighing about 200-250gm treated orally of ethanolic extract of plant Tridax procumbens at 300mg/kg body weight concentration for 3 and 5 days chronically. The result showed that both treated groups of rats are not showing very significant changes in protein content of Liver, Kidney, Uterus and Ovary of rats as compared to their control groups. Therefore, it is safe to use it against various...
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Posted by admin on Sep 1, 2010 in |
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, PNA, ONF, MND, PAH posses significant anti convulsant activity. However, all the compounds showed analgesic activity less than the reference standard. Anti bacterial activities of the compounds were evaluated against staphylococcus aureus and the zone of inhibition was measured as the parameter of activity. Amikacin, the standard showed a zone of inhibition of 18 mm out of 8 synthesized compounds only one PNN (Ia) compound showed an equal activity when compared with standard. In which (ONF, PAN) showed considerable anti bacterial activity. The remaining four compounds PNM, MNC, MNA, PAK showed moderate antibacterial activity. Anti bacterial activity of the compounds were evaluated against E. Coli and the zone of inhibition was measured as the parameter of...
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Posted by admin on Sep 1, 2010 in |
The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax Procumbens Linn. Tridax Procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. Thus from the extensive literature survey it was revealed that no reports were available on microscopic evaluation, standardization parameters and chemo profile of Tridax Procumbens to check the identity and purity of the drug. The present work embodies the investigations carried out to establish methods for quality control of drugs as per WHO guidelines: complete botanical evaluation which comprises macroscopic, microscopy physicochemical parameters like loss on drying extractive value, ash value and to investigate the Phytochemical present the extract in the preliminary level were carried out for the quality control of the drug. Thus it was thought worthwhile to explore this endangered plant on the basis of this standardization parameter. The study will provide referential information for the...
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