Posted by admin on Dec 1, 2010 in |
Calotropis procera (Asclepiadaceae) is an erect, perennial shrub luxuriantly thriving in wastelands. It is commonly distributed in most parts of India and also distributed in Persia, tropical Africa and other tropical countries of the World. The aqueous extract of some parts have laxative property and beneficial in skin diseases, ulcers, enlargement of the spleen, abdominal glands, liver diseases, promotes digestive power and also useful in colics. The milky exudate is useful in skin diseases, tumour and ascitis. It is a very good purgative. Here an attempt has been taken to evaluate the antioxidant activity, CNS depressant activity and also antimicrobial activity of methanolic extract of fresh flowers of C. procera. In result, the methanolic flower extract showed a significant activity against DPPH free radicals and the IC50 value is 64.87µg/ml. On the other hand, CNS depressant activity of the extract was also observed by using In Vivo model. In antimicrobial activity five different fungal species were inhibited by this extract and from the above study the flowers extract showed...
Read More
Posted by admin on Dec 1, 2010 in |
Garcinia indica is well spread in tropical rain forest of Western Ghats of India. Extract of dried fruit rind of kokum was prepared using methanol. Extract was evaluated for antioxidant and antihyperlipidemic activity. Garcinia was tested for antihyperlipidemic activity using cholesterol induced hyperlipidemic model in Albino Wistar rats. It exhibited significant reduction in total cholesterol, triglycerides, LDL-C, VLDL-C levels and increase in level of HDL-C when compared to Lovastatin. Artherogenic index and LDL-C: HDL-C ratio was also reduced to significant extent. Significant antioxidant and antihyperlipidemic activity may be due to the presence of polyphenols like Garcinol and hydroxycitricacid in...
Read More
Posted by admin on Dec 1, 2010 in |
In the present study, Solanum melongena Linn. (Brinjal; Solanaceae), was evaluated for its antiepileptic activity against experimental seizures. The roots ethanolic extract of Solanum melongena protected mice against tonic convulsion induced by maximal electroshock, Pentylenetetrazole and Picrotoxin. It was found that ethanolic extract up to a dose of 300 mg/kg p.o. decreased the duration of tonic extensor phase and delayed the onset of time of jerk against maximal electroshock induced seizure and pentylenetetrazole induced seizure. In Picrotoxin induced seizure, the extract at a dose of 200 mg/kg significantly increased the onset of clonic- tonic convulsion. These findings suggest that extract of the roots of Solanum melongena posses anticonvulsant effect and reduce mortality. The further studies to determine the mechanism(s) and compound(s) involved in the anticonvulsant...
Read More
Posted by admin on Dec 1, 2010 in |
A simple, rapid and accurate reverse phase high-performance liquid chromatographic method for the determination of 5-Flurouracil (5-FU) in pharmaceutical formulations and human plasma samples has been developed and validated. The assay of the drug was performed on a CLC C18 (5 μm, 25 cm 4.6 mm i.d.) with UV detection at 266 nm. The mobile phase consisted of methanol-water mixture in the ratio of 98:2, and a flow rate of 1 ml/min was maintained. The standard curve was linear over the range of 0.9-18.4 µg/ml (r2=0.9966). Analytic parameters have been evaluated. Within-day and between-day precision as expressed by relative standard deviation was found to be less than 2%. The method has been applied successfully for the determination of 5-FU in spiked human plasma samples and pharmaceutical formulations. The method will be useful for routine quality control...
Read More
Posted by admin on Dec 1, 2010 in |
Antioxidant activity of methanolic extract of Tectona grandis root was investigated for its free radical scavenging activity by determining the nitric oxide and superoxide radical scavenging activity. Maximum scavenging of nitric oxide and superoxide radical found were 26.61% and 46.64% respectively at 250 μg/ml concentration. The results were compared with rutin as a standard. These results clearly indicate that Tectona grandis is effective in scavenging free radicals and has the potential to be a powerful...
Read More
