Posted by admin on Feb 1, 2011 in |
Ayurvedic medicine plays a crucial role in healthcare and serves the health need of a vast majority of people in developing countries. Some clinically used ayurvedic herbal preparations were investigated (solvent extract preparation) for antibacterial potential against enteric bacterial pathogens such as Escherichia coli, Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa, Bacillus subtilis, Klebsiella pneumoniae, Salmonella typhi, Staphylococcus epidermidis, Salmonella typhimurium and Proteus vulgaris. In present study Shatawaryadi churna, Panchasakar churna, Talisadi churna, Dashmula churna and Manjistadi churna were potent antibacterial against Staphylococcus epidermidis, Proteus vulgaris, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi. Study suggested thatthese herbal preparations may be useful as an alternative medicine in the treatment of enteric bacterial...
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Posted by admin on Feb 1, 2011 in |
Crude ethanolic extract of Brassica nigra was studied to detect the chemical compounds as well as to evaluate the antioxidant and anti-inflammatory activities. The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, reducing power, total phenolic content and flavonoid content were studied. Phytochemical screening showed the presence of alkaloids, flavonoids, glycosides and carbohydrates in the extract. Total phenol content in the plant was 6.67 mg/g of galic acid. Brassica nigra was found to contain 2.04 mg/g of quercetin in flavonoid assay. Total antioxidant capacity of the extractwas found to be 97.08 mg/g of ascorbic acid. Brassica nigra showed IC 50 value of 63.09µg/ml whereas the standard antioxidant showed IC 50 value 14.45 µg/ml in DPPH method. The standard antioxidants ascorbic acid, galic acid and quercetin showed the reducing power 485.75%, 736.30% and 763.01%, respectively whereas Brassica nigra showed the value 263.69%. IC50 value in NO scavenging activity of the extract was found to be 118.21 µg/ml whereas ascorbic acid showed the value 5.47 µg/ml and...
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Posted by admin on Feb 1, 2011 in |
Some novel benzimidazole derivatives were synthesized with ibuprofen and evaluated for its activity. This compound showed notable antibacterial activity against gram-positive organisms and antifungal activity against when compared with respective...
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Posted by admin on Jan 1, 2011 in |
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat various ailments for over 100 years. As a class, these drugs possess anti-inflammatory, anti-allergy, analgesic and antipyretic activity. A series of benzothiazolyl-amides has been synthesized and tested for anti-inflammatory activity. Basic NSAIDs are gaining interest because of their improved biological properties with the aim of improving the therapeutic index through prevention of gastrointestinal complications. The title compounds were identified by performing Thin Layer Chromatography and recording their physical constants. They were further characterized by spectral analysis (IR, 1HNMR, Mass spectroscopy). The effect of the synthesized compounds on inflammation, using the carageenan induced mouse paw edema model was studied. In general, the studied compounds were found to be potent anti-inflammatory agents. Anti-inflammatory activity was influenced by some structural characteristics of the synthesized compounds. Some physicochemical parameters and ADME Properties were computed by using software...
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Posted by admin on Jan 1, 2011 in |
Antioxidant activities of different vegetables Bitter gourd, Tomato and Spinach (Momordica charantia, Lycopersicon esculentum, Spinacia oleracea) were determined. In addition, rapid visual estimation of tannin content, total phenolic, tested for their free radical scavenging activity (FRSA) in the DPPH (1, 1-dephenyl- 2-picrylhydrazil radical) of those samples were assessed. A new technique was used to quickly distinguish between intermediate, moderately high and high tannin content by the development of shades of purple, light blue and deep blue colors (Bitter gourd, Tomato and Spinach) respectively. The total phenolics in methanol solution for all the samples were analyzed with slightly higher value for spinach paste. The % of condensed tannin of all the three vegetables were low as determined by the Vanillin- HCl method respectively. The antioxidant activity with DPPH- method expressed as per percent inhibition of oxidation ranged from a high of 88% in bitter gourd extract to near about 70% in tomato and spinach respectively. The studies can be further extended to exploit their possible application for the preservation of...
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