Posted by admin on May 1, 2010 in |
The present endeavour was directed towards fabrication of the novel colon drug delivery system of ketorolac tromethamine capsule. Hard gelatin Capsules were fabricated using combination of both microflora activated natural polysaccharide (guar gum) and pH-dependent polymer (cellulose acetate phthalate). In vitro drug release studies revealed that Ketorolac tromethamine granules bearing hard gelatin capsules coated with cellulose acetate phthalate released drug only at higher pH (6.8 PBS), in vitro drug release studies showed that capsules were retained in stomach pH (1.2 N HCl) with-out any drug release, whereas minimal amount of drug release in small intestine pH (7.4 PBS) and almost drug release showed in the colonic pH (6.8 PBS). The rate of drug release was observed fast with caecal content (4% w/w rat caecal) than the control medium. Hence 50% guar gum containing coated capsules may be potentially useful for delivery of ketorolac tromethamine for colon. The drug release follows case ІІ (non- fickian) diffusion control...
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Posted by admin on May 1, 2010 in |
The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copiously branched perennial herb. Present work was undertaken to study antioxidant potential of the plant. Dried ethanol and aqueous extracts plant were screened for in-vitro antioxidant activity by DPPH assay and nitric oxide screening methods. Results showed that IC50 value of aqueous extract in DPPH assay and nitric oxide scavenging assay are 78 ug/ml and 89 ug/ml respectively. Phytochemical screening revealed that flavonoids, alkaloids, saponins, tannins and phenolic compound are present in aqueous extract and may be responsible for the activity. It can be concluded that the aqueous extract of T. purpurea L. root can be used as antioxidant and it can be recommended for the treatment of various...
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Posted by admin on Apr 1, 2010 in |
The hepatoprotective activity of juice of Saccharum officinarum was investigated against paracetamol (acetaminophen) induced liver damage in rats. Paracetamol (PCM) is analgesic, antipyretics drugs available as an over the counter (OTC) medication which cause hepatotoxicity as higher doses. Paracetamol at 3gm/kg induced liver damage in rats manifested by statically increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), total and direct billirubin. The antioxidant parameter malondialdehyde (MDA) level was increase and reduced glutathione (GHS), total protein (TP) level were decrease. The physical parameter of liver weight and volume also increase. Histopatholgical and in vitro (% of cell viability) studies of the experimental animals were also done. The results indicate that the juice of Saccharum officinarum protects against PCM-induced hepatotoxicity presumably via antioxidant action....
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Posted by admin on Apr 1, 2010 in |
Ketoprofen is a non-steroidal anti-inflammatory drug. Glucopyranoside Conjugates of Ketoprofen have been synthesized and evaluated for anti- inflammatory, analgesic and ulcerogenic activities. In vivo biological screening in mice and rats indicated that conjugates improved analgesic and anti-inflammatory activities with significantly reduced ulcerogenicity compared to the parent...
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Posted by admin on Apr 1, 2010 in |
The study is aimed at development of Physico-chemical parameters and to investigate the active principle present in Chlorophytum borivilianum. Chlorophytum borivilianum San. and Fern. (Liliaceae) commonly known as Safed Musli is an important plant used against various disorders in indigenous systems of medicine, such as antioxidant, analgesic, and as a remedy for male impotence and to boost the immune system. This plant is to be considered as an endangered plant due to its potent use in many of the tribal areas in India and used widely in Traditional System of Medicine. Thus from extensive literature survey it was revealed that no reports were available on microscopic evaluation, standardization parameters and chemoprofile of Chlorophytum borivilianum to check the identity and purity of the drug. The present work embodies the investigations carried out to establish methods for quality control of drugs as per WHO guidelines: complete botanical evaluation which comprises of macroscopy, microscopy, physico-chemical parameters like Loss on Drying, Extractive values, Foaming index, Ash values and to investigate the phytochemical present...
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