Posted by admin on Oct 1, 2010 in |
The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8) MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram +ve (Bacillus subtilis and Staphylococcus aureus) and gram -ve (Shigella flexneri, Salmonella typhosa, Escherichia coli) and some fungi (Aspergillus flavus, Fusarium oxysporum, Chrysosporium pannicale, Alternaria solani, Candida albicans )....
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Posted by admin on Oct 1, 2010 in |
A simple, precise and reproducible liquid chromatography–tandem mass spectrometry method has been developed and validated according to the United States – Food and Drug Administration (US-FDA) guidelines for the quantitation of Montelukat in human plasma using Neverapine as an internal standard. Montelukast is a fast acting and potent cysteinyl leukotriene receptor antagonist which is being used in the treatment of asthma. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in multiple reaction monitoring and positive ion mode. The chromatographic run time was 3.2 mins on a Agilent Zorbax SB C8, 150×4.6 mm, 5.0µm Column. The mobile phase was a mixture of Methanol: 0.1 % Formic acid in water (90:10 v/v). Inter-batch and intra-batch coefficient of variation across four validation runs for the quality control samples was less than 6.02%. The accuracy determined at quality control levels was within 90.98 –...
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Posted by admin on Oct 1, 2010 in |
Rhein and several analogues thereof, are particularly important from commercial point of view and are known for their use in the treatment of degenerative diseases of the joints, for example osteoarthritis, osteoporosis and rheumatoid arthritis. Rhein occurs in nature in plant families such as Cassia, Rheum and Rhamnus, but in a very less concentration. Aloin, a natural substance isolated from various species of aloe, consist almost exclusively of barbaloin (10-β-glucopyranosyl-1, 8-dihydroxy-3-hydroxymethyl-anthracen-9-one). Barbaloin, the C-glycoside of aloe-emodin anthrone, localizes in the outer rind of the aloe vera leaf, has been reported to constitute upto 30% of aloe plants dried leaf exudate and proposed as a part of defense mechanism against herbivores. In this paper, an attempt has been made to prepare rhein from barbaloin via formation of aloe-emodin and its chemical modification using benzyl alcohol to prepare its benzyl carboxylate...
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Posted by admin on Sep 15, 2010 in |
Aqueous extract of the fruits of the plant Piper longum was studied for their Anti rheumatoid activity in Freunds Adjuvant Induced Arthritis Rats with the dose of 200 and 400 mg/kg p. o. The administration of extract reported significant reduction in paw swelling on 4th, 8th, 14th and 21st day after sub-plenter administration of Complete Freunds adjuvant. The paw swelling was measured as a volume displacement using digital Plethysmometer. Furthermore, these results supported by radiographic analysis of affected knees of rats. From the results observed in the present investigation, it may be concluded that the aqueous extract of P. longum possesses potentially useful anti-arthritic activity in Complete Freunds Adjuvant...
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Posted by admin on Sep 15, 2010 in |
Medicinal plants are a major source of therapeutic agents since time immemorial. Tribal and rural community from their parents on folklore medicines acquires incredible knowledge of phytomedicine in non-coded form. With the repeated discussions and consultations with Tribal and Bhumkas, we selected 36 different medicinal plants of 30 families used against enteric infections form Melghat forest (Amravati district). Antibacterial activity with extracts prepared in aqueous, ethanol, methanol, and acetone was performed by disk diffusion method against bacterial enteric pathogens such as E. coli, S. aureus, E. aerogenes, Ps. aeruginosa, S. typhi, S. typhimurium, S. paratyphi, Pr. vulgaris, K. pneumoniae and Sh. flexneri. Acacia arabica leaves proved strong antibacterial against E. coli, S. aureus, E. aerogenes, Sh. flexneri, S. paratyphi and S. typhi. In Terminalia chebula fruits and Terminalia bellirica fruits strong antibacterial potential was observed against E. coli, E. aerogenes, Ps. aeruginosa and S. typhimurium. Phytochemical analysis showed presence of fats, oils, alkaloids, cardiac glycosides, anthraquinones, tannins, and...
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