Posted by admin on Sep 15, 2010 in |
Soils generally contain adequate amount of inorganic and organic phosphorous but most of these remain unavailable to plants. The efficiency of water soluble phosphorus alone is usually low and soluble phosphorus when added to soil along with phosphate solubilizing microorganisms indicates utilization. The presence of soil microorganisms capable of transforming insoluble phosphorus to soluble form of phosphorus was studied Different phosphate dissolving bacterial strains are isolated from the rhizosphere soil of Costus plant and biochemical characterization and P2O5 uptake in liquid culture was...
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Posted by admin on Sep 15, 2010 in |
Objective: The selective COX-2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the health due to chances of less adverse effects. So the main objective of this research work is to lower the dose of selective COX -2 inhibitor, combine with a conventional NSAID and find out the pharmacological activity of combination drug, selective cox-2 inhibitor alone and other standard NSAIDs and compare with control. Methods: Carrageenan induced hind paw edema in Rats and Brewer’s yeast induced pyrexia in rat models were used for the evaluation of anti-inflammatory and antipyretic activity. Results: The % age of inhibition of edema at peak hrs i.e. at 3 and 4 hrs were (51.8%) and (49.7%) for standard drug (62.1%) and (59.3%) for test-1 drug (71.4%) and (70.1%). The percentage of reductions in rectal temperature of tests and standard group was shown in Graph-1 b. The present results show that...
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Posted by admin on Sep 15, 2010 in |
This study was undertaken to examine the antioxidant activity of methanolic extract of rhizomes of Curcuma caesia using DPPH free radical scavenging assay. The IC50 (The concentration of sample required to scavenge 50% of DPPH free radical) was calculated by plotting graph between % inhibition vs concentration. The Butylated Hydroxytoluene was used as standard antioxidant in comparison to methanolic extract of Curcuma caesia. The IC 50 value of extract and Butylated Hydroxytoluene was found to be 862.35 µgm and 46.25 µgm for 2 ml of 500 µM concentration of DPPH. This suggests that methanolic extract of Curcuma caesia had moderate IC 50 value as compared to Butylated...
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Posted by admin on Sep 15, 2010 in |
Aim: Litsea glutinosa (L.) a medicinal plant is popularly used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic potential of the ethanolic extract of the bark of the plant. Approach: The analgesic activity of standard tramadol HCl was determined for its central pharmacological actions using hotplate method in mice. Simultaneously the ethanolic extract was also investigated for its analgesic action. Results: The extract, at the dose of 100 and 300 mg/ Kg, has shown a significant (p<0.05) increase in pain threshold in hotplate, as compared with control...
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Posted by admin on Sep 15, 2010 in |
Chlorpyrifos (CPF) an Organophosphate insecticide was evaluated for its potential to produce reproductive toxicity in rats following oral exposure. In the present study mice were given CPF at the dose level of 10 mg/kg body weight by Gavage method for 14 and 21 days. Morphological alterations of ovary were examined under LM. Its oxidative stress levels were also evaluated by Lipid peroxidation levels and hormonal changes (FSH) were also measured to evaluate the fertility rate in case of CPF induced toxicity mice. Bioremediation was done to the toxicity induced mice using extracted curcumin at 100 mg/kg body weight for 7 days. In control group, the germinal epithelium was continuous with prominent and well defined different stages of graffian follicles. While in chlorpyrifos treated group ruptured germinal epithelium with multiple nuclei were observed. Degenerated ovum was observed in matured graffian follicles. Rudimentary cells were observed in corpus leutium. Many vacuolated spaces were observed in ovarian cortex which is unusual. Significant increase in serum LPO levels and decrease in FSH levels...
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