Posted by admin on Mar 1, 2010 in |
Gastroretentive dosage forms have potential for use as controlled drug delivery systems. Multiple unit systems avoid the “all-or-none” gastric emptying nature of single unit system. A controlled release system designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating microballoons by the emulsion solvent diffusion technique using acrylic polymers (i.e. Eudragit RS-100 and Eudragit S-100) with drug (metformin) in a mixture of ethanol, dichloromethane and propanol. The effect of various formulation and variables on the internal and external particle morphology, micromeritics properties, in vitro floating behavior, physical state of the incorporated drug, drug loading and invitro drug release was studied. The microparticles were found to be regular in shape and highly porous. The release rate was determined in simulated gastro-intestinal fluids at 37oC. The formulation demonstrated favorable invitro floating and release characteristics. The drug encapsulation efficiency was high. Incorporation of Eudragit RS-100 and Eudragit S-100 in the microballoons proved to be an effective method to achieve the desired...
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Posted by admin on Mar 1, 2010 in |
The present study concerned with the development and characterization of bioadhesive vaginal film (VF). Zidovudine containing VF were prepared by solvent casting method using different ratios of Acrycoat S 100 (AC) or Ethyl cellulose (EC) to Hydroxy propyl methyl cellulose (HPMC) and di butyl phthalate(DBP) as a plasticizer. The optimized films were found to be transparent, flexible and soft and evaluated for mechanical properties by modified instrument, drug content, folding endurance, in vitro drug release with release kinetic and % moisture content bioadhesive strength by modified pan balance method. The films were found higher drug content and flexible. The VF10 (containing AC: HPMC 4:1) was selected. In vitro drug was found of Zidovudine over 11 hr obeying zero order followed by Higuchi kinetics and Case II non-Fickian (anomalous) diffusion control, indicating the rate of drug release is due to the combined effect of drug diffusion and polymer relaxation with a sufficient bio adhesion quality with good mechanical properties. The results were compared statistically and found with satisfactory correlation. Thus...
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Posted by admin on Feb 1, 2010 in |
Condensation of thiaourea with chloro acetic acid gave Thiazolidinedione which react with aromatic aldehyde and produce 5- benzylidine, 2, 4 Thiazolidinedione.To this different secondary amine was reacted and final derivatives was obtained. The structures of these compounds were established by means of IR, 1 H-NMR.All the compounds were evaluated for antidiabetic activities. Most of the compounds have shown significant antidiabetic activity when compared with the standard...
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Posted by admin on Feb 1, 2010 in |
The antimicrobial activities of aqueous, ethanolic and petroleum ether extracts of the leaves of Basella rubra were evaluated in the present study by measuring the inhibition zones using Cup Plate Diffusion method. The inhibition zones were significantly different (P<0.001) in each plant extract. The ethanolic extract showed maximum activity with zone of inhibition (14.3±1.82 mm) against E.coli, followed by aqueous extract (13.4±1.2 mm) and petroleum ether (5.6±0.62 mm) at a concentration of 50g/ml. Ciprofloxacin was used as the standard drug having zones of inhibition(17±0.34 mm) against E.coli and 19±0.18 mm against A. niger. Microbial inhibition was in the order E.coli (12.57±0.99), A. niger (11.68±0.71), V. cholera (11.42±0.60), S. aureus (10.71±0.46), S. typhi (9.80±0.90) , respectively with all the extracts. The extracts were not able to inhibit the growth of P....
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Posted by admin on Feb 1, 2010 in |
Vasicine is a pyrralazoquinazoline monobasic alkaloid obtained from the Plant Adhatoda vasica. In the present paper, the experiment were carried out to synthesis the various analogs of Vasicine, where the five membered ring C, was converted to seven membered ring, thus producing 7,8,9,10-Tetrahydroazepino[2,1-b] quinazolin-12(6H)one (RLX), was reported to be 6-10 times more potent than aminophylline as a bronchodilatory agent. A series of new compounds were synthesized, as modification in ring A and in ring B. The resulted compounds were evaluated for the antihistaminic activity to synthesis even more potent compounds....
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