Posted by admin on Jul 1, 2010 in |
Paliperidone is a new active substance, belonging to the class of atypical antipsychotic, and is the active metabolite of a well-known active substance, risperidone that has been used for the last 3 years. A randomized, double-blind, multicentric, study to evaluate the safety and efficacy of Paliperidone ER compared to Olanzapine in patients with Schizophrenia was conducted in Indian schizophrenic patients. Pharmacokinetic Evaluation in Indian schizophrenic patients randomized to Paliperidone ER was an open label extension, pharmacokinetic (PK) study of previously conducted phase III trial. The doses of paliperidone 3, 6, 9, and 12 mg were administered during the study. Paliperidone concentrations were measured up to 36 hours post dose after administration of paliperidone ER 30 minutes after dinner to the patients who continued the medication after completion of phase III clinical trial. The mean Cmin, Cmax, AUC (tau) for paliperidone ER 3 mg, 6 mg, 9 mg, 12 mg were found to be [6.71 ng/ml, 23.59 ng/ml, 349.50 hr*ng/ml]; [28.88 ng/ml, 57.77 ng/ml, 1040.86 hr*ng/ml]; [17.25 ng/ml, 71.05 ng/ml,...
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Posted by admin on Jul 1, 2010 in |
The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using superdisintegrating agents. Recently fast disintegrating drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as a bronchodilator. It forms part of initial therapy of acute as well as chronic asthma. In present work an attempt has been made to formulate and evaluate fast disintegrating tablets of Salbutamol Sulphate. Ac-di-sol, Polyplasdone and Primojel were used as super disintegrating agents, while microcrystalline cellulose and mannitol were used as diluents. Direct compression technique was used as it requires conventional tablet machinery and thus economical process. Formulations containing Ac-di-sol as super disintegrating agent show rapid in-vitro and in-vivo dispersion time as compared to other...
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Posted by admin on Jul 1, 2010 in |
The antioxidants such as quercetin and alpha- tocopherol were subjected for in vitro prophylactic cataract prevention study on glucose induced cataract model. Goat lenses were incubated in artificial aqueous humor containing 55 mM glucose with test drugs in different concentrations at room temperature for 72 h. Biochemical parameters studied in the lens were electrolytes (Na+, K+), Na+– K+– ATPase activity, malondialdehyde (MDA) and proteins. Glucose induced opacification of goat lens began 8-10 hrs after incubation and was complete in 72-80 hrs. Cataractous lenses showed higher Na+, MDA (P<0.001), lower Na+-K+– ATPase activity, and water-soluble protein content. Lenses treated with test drugs has shown higher protein content and prevented formation and progress of cataract by glucose, as evidenced by biochemical parameters....
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Posted by admin on Jun 1, 2010 in |
Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in 1:1 and 1:2 ratios to study the effect of PVP in dissolution profile of drug. Dissolution study showed a linear increase in paracetamol release with increase in polymer concentration. Two different batches of granules are also evaluated for their micromeritics properties and flow behavior. The micromeritics properties and dissolution profile showed a evident that PVP can be used to improve dissolution behavior of...
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Posted by admin on Jun 1, 2010 in |
Barberries are a large group of evergreen shrubs, found in Lalitpur, Allahabad, Bhopal and Haldwani etc. It is an evergreen shrub. Commonly, its fruits are called as berries. This plant is generally use in case of diabetes and mouth ulcer, as a traditional use. Type 2 diabetes mellitus (formerly called NIDDM, type II or adult-onset) is characterized by insulin resistance in peripheral tissue and an insulin secretory defect of the β- cell. This is the most common form of diabetes mellitus and is highly associated with a family history of...
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