Posted by admin on May 1, 2010 in |
Inflammation is a biological reaction attributed with several acute and chronic pathological conditions. The study revealed the pharmacological effect of Tecomella undulate: bark against carrageenan induced paw edema and cotton pellet induced granuloma in rat. Wistar albino rats of either sex (180-240 g) were employed into the study. Acute inflammation was induced by injecting carrageenan (1%) in rat paw and estimated using plethysmograph. Chronic inflammation was induced by cotton pellet induced granuloma method. Serum nitrate/nitrate estimation was also done as an index of inflammatory reactions. Acute toxicity study was also done using Swiss albino mice. Butanolic and water fractions of Tecomella undulate (200 & 400 mg/kg) and indomethacin (10 mg/kg) were used as test drugs. Carrageennan caused a marked increase in rat paw volume due to edema formation. T. undulate: butanolic fraction significantly inhibited paw volume in successive hours similar to indomethacin. Interscapular implanted cotton caused significant increase in granuloma wt. and serum nitrate/nitrite level in control group. However, the test drugs lowered the effects of cotton pellet induced...
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Posted by admin on May 1, 2010 in |
Diabetes induced neuropathic pain is recognized as one of the most difficult pain to treat and conventional analgesic are well known to be partially effective or ineffective. Non-steroidal anti-inflammatory drugs and opioids are effective antinociceptive drugs, however, their antinociceptive activity decreased in diabetic neuropathy. The study was designed to investigate the mechanism of diabetes induced decrease in the antinociceptive effect of analgesics in rats. Streptozotocin (STZ) (20 mg/kg, i. p. 4 days) was administered to induce experimental diabetes in the rats. One week after the administration of STZ, the tail-flick and paw withdrawal test was performed. Spleen homogenate supernatant (SHS) was prepared from spleen of 28th day diabetic rats and administered to normal rats (400 µl, i. v.) for 28 days. Thermal hyperalgesia was noted in both diabetic and SHS (400 µl, i. v.) treated non-diabetic rats. Moreover, analgesic effect of morphine (8mg/kg, s.c.), lysine acetylsalicylic acid (400mg/kg i. v) and indomethacin (10 mg/kg, i. p.) was progressively decrease in diabetic and SHS of 28 day diabetic treated non...
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Posted by admin on May 1, 2010 in |
Oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration. Carbopol 934p as a primary polymer and HPMC K15M, HPMC K4M, and HPMC K100M as secondary polymers in different proportions has been used to formulate the desired mucoadhesive formulation with other tablet excipients and lubricants to give good compressibility by dry granulation method. The tablets were characterized by weight variation, hardness, thickness, friability, swelling ability, dissolution profile, assay and mucoadhesive strength. The selected mucoadhesive formulation FC2 exhibited 99.51% of drug release in 24 hrs, the mucoadhesive strength was found to be 95.04 gm so it has enough strength to adhere on the mucosa for an extended period of time. Kinetic study has been studied for the selected formulation it follows zero order release and matches with Higuchi regression....
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Posted by admin on May 1, 2010 in |
Objective of the study was to assess the anticonvulsant activity of extracts of Hibiscus rosa sinesis in albino rats. Methods: The anticonvulsant activity of extracts of flowers of Hibiscus rosa sinesis in rats were assessed using maximum electroshock seizure (MES) test and isoniazid (INH) using albino rats. The time taken before the onset of clonic convulsions, the duration of colonic convulsions and mortality protection were recorded. Results: The alcoholic extract of Hibiscus rosa sinesis flowers decreased the duration of hindlimb extension; clonus and stupor phase of MES induced convulsions as compared to control. However, all the extracts of flowers of Hibiscus rosa sinesis Linn. did not show any significant anticonvulsant activity against INH induced seizures. Conclusion: The alcoholic extract of Hibiscus rosa sinesis inhibits MES -induced convulsions but not INH-induced convulsions in animal...
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Posted by admin on May 1, 2010 in |
The present study deals with evaluation of antioxidant, wound healing and anti-inflammatory activity of ethanolic extract of leaves of Ficus religiosa. The ethanolic extract prepared by maceration technique was subjected to screen for antioxidant activity using DPPH radical scavenging method and wound healing activity using incision, excision, histopathological and dead space wound model and the study was supported with evaluation of granuloma tissue to estimate hydroxyproline content and histopathological evaluation. The anti-inflammatory study was carried out by using carageenan induced rat paw odema method. The tested extract of different dilutions in range 200µg/ml to 1000 µg/ml shows activity in range of 6.34% to 13.35%. Significant increase in wound closure rate, skin breaking strength, granuloma breaking strength was observed. The hydroxyproline content was also increased with decrease in scar area. The initial healing action might be due to increased collagen deposition and better alignment, with the obtained results it can be concluded that Ficus religiosa extract has significant wound healing activity and initial healing may be due to presence of...
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