Posted by admin on May 31, 2023 in |
Atherosclerosis is a chronic inflammatory disease that is marked by atheroma and patchy intimal plaques in arteries that cause thickening and hardening of arteries. It is reported that “Origanum majorana L.” possess antiulcerogenic, antiproliferative, antioxidant, and anticarcinogenic activities, and it is an important remedy against thromboembolic disease. The present study was designed for the evaluation of the anti-atherosclerotic activity of hydrodistilled volatile oil (OMO) of Origanum majorana L. in high-fat diet-induced atherosclerotic rats. The in vitro studies found that OMO possesses fibrinolytic, thrombolytic, and antiplatelet activity. These activities can play an effective role in the anti-atherosclerotic activity of OMO. Atherosclerosis was induced using a high-fat diet model in atherosclerotic activity of OMO. Atherosclerosis was induced using a high-fat diet model in histopathological examination of the aorta was determined at the end of the study. OMO significantly showed that the levels of total cholesterol (TC), triglyceride (TG), low-density lipid (LDL), and very low-density lipids (VLDL) levels were also decreased, there is a decrease in the level of liver function enzymes...
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Posted by admin on May 31, 2023 in |
Background: To enhance patient compatibility Safoof e Muhazzil (powder) was compressed into tablets. Objectives: The present study was aimed at comparing the two dosage forms for any variations in the efficacy of Safoof e Muhazzil. Method: This triple-armed RCT was carried out on 90 patients after obtaining ethical clearance and written and informed consent. The study period was six weeks. Improvement was measured in terms of change in weight, BMI, waist hip ratio (WHR) and waist circumference (WC). 5g of powdered Safoof e Muhazzil (SMC) was given twice daily with water, whereas, 5 tablets of Safoof e Muhazzil (SMT) were given twice daily with water. The third group was given atarvostatin 10 mg once daily. Result: The study recorded a 20.03 % dropout. Most of the patients were non-alcoholic, non-smoker, non-vegetarian males above 45 years and had BMI between 25-30 kg/m2. SMC and SMT gave similar results on all parameters of weight management with p<0.001. This can be attributed to the anti-oxidant and lipolytic properties of Safoof e Muhazzil...
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Posted by admin on Apr 30, 2023 in |
This study describes the implementation of a Quality by Design approach to develop and validate the RP-HPLC for amlodipine and valsartan. The reaction surface method optimizes by adopting the three-level Box Behnken design. The three factors selected are methanol and water concentrations (mobile phase), flow rate, and wavelength. The developed chromatographic method was validated against the ICH Q2(R1) guidelines for linearity, range, precision, LOD, and LOQ. The maximum absorbance of amlodipine and valsartan (λ max) was found to be 245 nm. The optimized method consists of mobile phase Methanol: Water (pH 3.0) (80:20), and flow rate 0.9 ml/min, which was optimized by using design expert software. Linearity of the developed method was established over the concentration range of 1 10 μg/ml for Amlodipine and 30 – 200 μg/ml with correlation coefficients (r2) of 0.997 and 0.9993, respectively. The percent RSD for accuracy and precision of the method was found to be less than 2%. The limit of detection (LOD) was 0.08 µg/ml and 0.89 µg/ml for Amlodipine and Valsartan,...
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Posted by admin on Apr 30, 2023 in |
This research aimed to develop an inclusion complex of resveratrol (RSV)/hydroxypropyl-β-cyclodextrin (HP-β-CD) using a quality-by-design (QbD) approach to improve the solubility and stability of RSV and formulate it into a fast-dissolving sublingual film (FDSF). The RSV/HP-β-CD inclusion complex was prepared by the kneading method using a Box–Behnken Design to assess the effect of the molar ratio of RSV and HP-β-CD, reaction time, and drying time as independent variables on the % entrapment efficiency and % yield. FTIR, DSC, Powder XRD, NMR, and SEM were performed to evaluate the formed complexes. The RSV/HP-β-CD complexation was successful in enhancing RSV solubility and stability. Furthermore, the inclusion complex was incorporated into a fast-dissolving sublingual film. The prepared films were evaluated for a folding endurance test, tensile strength, disintegration time, drug content, thickness, and SEM. The sublingual route of administration was found to be beneficial for films, as it provided 80% permeation of RSV in 60 minutes and no damage to the epithelial tissues was observed in the histopathological study performed on the...
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Posted by admin on Apr 30, 2023 in |
Pancreatic cancer is an intractable and rare malignancy ranked 12th in incidence and 7th in mortality. It is the leading cause of cancer deaths in developed countries and is rising in developing countries like India. According to GLOBOCAN 2020 statistics, pancreatic cancer has ranked as the 11th most common malignancy in the world and accounts for 495773 new cases and caused 466003 deaths in 2020. Tumor hypoxia is an important pathological condition that influences several signaling cascades in malignant cells, eventually leading to therapy resistance. Several natural bioflavonoids hold promise as anti-cancer agents. However, the effect of Quercetin on hypoxic pancreatic cancer cells is unknown. We analyze the effect of Quercetin on expression levels of metastatic markers HIF1α and E-cadherin under hypoxic conditions. Quercetin treatment was significantly correlated with reduced HIF1α expression levels and elevated E-cadherin levels. Our results suggest that Quercetin may alter E-cadherin levels by regulating HIF1α expression. Quercetin may inhibit pancreatic cancer cell metastasis by regulating metastasis genes in a hypoxic microenvironment and has pharmacological potential...
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