Posted by admin on Apr 30, 2023 in |
Novel drug delivery approach by using natural polymers is a newer area of formulation development. The oral drug delivery in the buccal cavity to treat the dental infections has some limitations such as slow onset of actions and is also affected by the first pass metabolism. In order to overcome these challenges plant derived mucoadhesive gum from the fruit pulp of Ziziphus mauritiana L.(ZM) is used in the preparation of Denticap and evaluated in vitro for to analysis its sustained release action. Antibacterial drug Amoxycillin Trihydrate has been taken as the model drug. The denticap was formulated using Carbopol 934P, Z Mgum, Ethyl cellulose and ethanol by solvent evaporation technique. The physicochemical parameters such as swelling index, surface pH, tooth adhesion test etc were carried out. The swelling % ranges from 40-55%. The tooth adhesive strength and pH was 45g and 6.7 respectively. The cumulative drug release from the ZM denticap was found to be 67% at 30 hr. The drug release kinetic study shows that formulation follows diffusion...
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Posted by admin on Apr 30, 2023 in |
Background: Infections occur when viruses, bacteria, or microbes enter the body and multiply. Control of infection is achieved by using antibiotics; hence scrutiny of antibiotic prescribing patterns is an important aspect of quality and standards of clinical practice. Objective: To evaluate and analyse drug utilization and prescription pattern of antibiotics in various in-patient departments of the hospital to ensure safe and effective use. Methods and Material: A Retrospective Observational Study was carried out in 6 inpatient departments of Vivekananda General Hospital, Hubballi over a period of 1 year. A total of 993 prescriptions were collected, and the results were analyzed using MS Excel 2020, and SPSS 16.0. Results: This study reveals that the majority of patients belonging to the age group 41-60 years, received antibiotic therapy. Most patients were prescribed with antibiotic Ceftriaxone, 21.19% (n=402). Majority of the patients received antibiotics for Prophylactic treatment (44.65%). It was found that most of the patients were prescribed only one antibiotic (43.1%) whereas only 2.51% of patients were prescribed more than 4...
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Posted by admin on Apr 30, 2023 in |
A 30 years male patient from Chennai has presented with asymptomatic, grey-blue hyperpigmented patches of variable shape and size and an elevated erythematous border; the eruption has been symmetrically distributed on the face, the trunk, and the upper extremities for 4 years. This condition was diagnosed as “erythema dyschromicum perstans” which resembles to karunguttam one of the skin diseases in siddha system of medicine. He was treated with siddha medicines as Meganathakulikai for purgation to rearrange three humours (vatham, pitham & kabham), internal medicines (Rasaganthi mezhugu Capsules (RGM), Amukkarachooranam tablet, Seenthilsarkarai chooranam, Keelanelli chooranam tablets) & external medicine (Aruganthylam) @ Sirappu Maruthuvam OPD No: 3, Ayothidass Pandithar Hospital, National Institute of Siddha, Chennai-47 for 48 days. There were no adverse reactions or events observed during the course of treatment. The skin lesion of EDP reduced spontaneously in the treatment period, which is compared by before & after photocopies. This is the first case report in siddha for management of EDP larger study needs to confirm these...
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Posted by admin on Apr 30, 2023 in |
Background: Numerous methods have been used to induce myocardial ischemia (MI) in Experimental animals. MI induction using chemicals like isoproterenol in animal models is a simple and standardized method with fewer complications. Various doses of Isoproterenol were used extensively as an inducing agent. Aim: The present research aimed to evaluate the effect of Isoproterenol on the heart and lungs of male Wistar albino rats at different doses. Methods: Wistar albino rats were categorized as five groups with six animals each and administered with ISO for two days. Serum and histopathological studies were done. Results: Biochemical alterations and Microscopic features of the tissues showed pathological changes such as focal areas of inflammation, edema and vacuolar changes, and necrosis according to the dose administered, confirming myocardial injury and related necrotic lesions. Conclusion: These findings provide an idea and support fixing the dose for the inducing agent ISO for further cardioprotective...
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Posted by admin on Apr 30, 2023 in |
Batch cultures of two cyanobacterial species i.e., Nostoc commune and Anabaena variabilis were used to evaluate the impact of UV-B radiation on growth, photosynthetic pigments, lipid peroxidation, proline content, protein content as well as on the enzymes nitrate reductase and glutamine synthetase. The essential targets of UV-B radiation are the photosynthetic apparatus, photosynthetic pigments, and the excitation energy transfer. The UV-B radiation adversely inhibited the growth and photosynthetic pigments in both cyanobacterial strains. The content of Malondialdehyde increased by two-fold in both cyanobacterial species upon prolonged UV-B exposure. Protein content showed varied responses in both cyanobacterial species on UV-B exposure. Anabaena variabilis showed a decrease in protein content, whereas in Nostoc commune protein content elevates with an increase in UV-B exposure duration. With the increase in the duration of UV-B exposure up to 72 hrs the proline content in both species of cyanobacteria increased. Following the different duration of UV-B exposure in the following species, the in-vivo Nitrate reductase activity increased while in-vivo Glutamine synthetase activity decreased, although the...
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