Posted by admin on Jan 31, 2023 in |
The BSC sample was collected at four sites from the arid region of Rajasthan and these isolates were characterized based on morphological and biochemical parameters. We have to isolate both heterocysts and non-heterocysts cyanobacterial species. Oscillatoria tenuis species showed maximum chlorophyll accumulation and Phormium showed maximum carotenoids compared to heterocystous forms. The soluble protein content is high in Non-heterocystous Phormium and Oscillatora curviceps and lowest in heterocystous Nostoc linckia. Heterocystous forms Nostoc commune and Anabaena variabilis were synthesizing high carbohydrates compared to nonheterocytstous forms. Highest nitrogenase activity in Nostoc linckia isolated from Achorl...
Read More
Posted by admin on Jan 31, 2023 in |
Malaria is the most important parasitic disease in humans, with transmission occurring in over 100 countries with a population of three billion people. Protozoan parasites of the genus Plasmodium cause it. These parasites are transmitted from one person to another by the female anopheles mosquito. Medicinal plants possess many phytochemicals of great therapeutic value, and many effectively kill malaria parasites. These compounds working by variety of mechanisms and in most of the cases they exhibit their antimalarial potentiality by inhibiting many proteins involved in cell growth and division. Molecular docking is a computational approach which facilitates the finding of the best molecule from a group which may bind with the highest affinity with the intended target by providing a virtual biological system. This process works on the basis of specific algorithm and involves scoring function to rank the molecules that fit with the target. The present study has been designed to investigate the antimalarial potential of seven alkaloid compounds from the leaves of Bauhinia purpurea. Three standard antimalarial drugs...
Read More
Posted by admin on Jan 31, 2023 in |
This work aimed to explore how crude aqueous extract of Jussiaea repens affected oxidative stress and metabolic status in streptozotocin (STZ) induced diabetic male rats. The diabetic rats were gavaged with aqueous extract of Jussiaea repens (50 mg/100 g body weight/day for 32 daysconsicutively) after an induction of STZ (8 mg/100g body weight, i.p.). Fasting blood glucose, insulin, serum LDH, total GSH, MDA, G-6-PDH, amylase, lipase, catalase and superoxide dismutase were measured. The hepatic levels of hexokinase, PFK, G-6-Pase, F-1,6-BPase and glycogen were also measured. The aqueous extract of Jussiaea repens decreased blood glucose level in diabetic control group. The extract supplemented group also demonstrated a notable improvement in blood insulin levels, SOD, GSH and G-6-PDH level in comparison to diabetic group. In diabetic group, the LDH and MDA levels were significantly higher than non-diabetic control rats and were significantly recovered in extract supplemented group. But catalase level showed no significant change. The liver glycogen, hexokinase and PFK were lower in the diabetic group, whereas G-6-Pase and F-1,6-BPase were...
Read More
Posted by admin on Jan 31, 2023 in |
A rapid, sensitive, selective and robust quantitative densitometric high-performance thin-layer chromatographic method is developed and validated for separation and quantification of flavonoids namely rutin, quercetin, kaempferol and myricetin in herbal formulations. The separation is performed on silica gel 60F254 high-performance thin-layer chromatography plates using phase cyclohexane: ethyl acetate: formic acid 12:9:0.4 (v/v/v) as the mobile phase. A precise and accurate quantification is performed using linear regression analysis by plotting the peak area vs concentration in range of 200–1000 ng/band with regression coefficient, R2 from 0.997 to 0.998 for selected flavonoids. The developed method is validated in terms of accuracy, recovery and inter- and intraday study as per International Conference on Harmonisation (ICH) guidelines. The method is found sensitive, accurate and reproducible. Therefore, it can be recommended for marker-based standardization and quality assurance. The present research work is an attempt for simultaneous quantification of rutin, quercetin, kaempferol and myricetin in a single mobile phase. The validated HPTLC method can be further applied to evaluate the quality of any plant reported...
Read More
Posted by admin on Jan 31, 2023 in |
The cases of skin infections are increasing daily, and the conventional treatment loses its strength in treating those skin infections because of resistance of the microorganisms against the medications, including antibacterial as well as antifungal with the topical and oral administration, or both. The advancement of the treatment of treating skin infections by the combination with the synthetic drug (allopathic medicine) with the polyherbal formulation is known as Allopolyherbal formulation, which gives a wonderful result in the treatment of skin infections due to microorganisms (bacteria & fungus) by lowering the side effects and increasing the pharmacological activity of the synthetic drug (allopathic medicine) with the synergistic therapy in targeting the microbes and also shows the better patient compliance with the reliable therapeutic effects. In this research work, the allopolyherbal formulation contains the polyherbal formulation, which includes A. indica (Neem), O. tenuiflorum (Shyamatulsi), P. emblica (Amla), and A. barbadensis (Aloe) which have the potency enriched with antimicrobial activity and the allopathic drug, the antibacterial (chloramphenicol) and antifungal (terconazole) are used...
Read More
