Posted by admin on Jan 31, 2023 in |
Hydrogels are cross-linked polymers with the capacity to bulge in an aqueous medium. Because of their extraordinary properties, these are utilized as brilliant drug delivery vehicles that particularly necessitate focusing on the drug to specific sites. On account of the eminent hydration and biocompatibility properties generally utilized in pharmaceutical field, especially cellulose derivatives. In oral medication, many advanced technologies are introduced. More recently pulsatile drug delivery system is meant for the release of drug followed by a predetermined lag time, which is an emerging approach in chronotherapeutics. In the current research work intended to formulate the pulsicapsules of miglitol by utilizing hydrogel plugs which were prepared by cellulose ethers like ethyl cellulose and sodium carboxymethyl cellulose in ratios of drug: polymer, i.e., 1:2, 1:3. Zero size capsule bodies were treated with formaldehyde to adjust the solubility of capsules and pulsicapsules were prepared by filling the bodies with three dosages of immediate release granules of miglitol which were separated by two hydrogel plugs and closed with an untreated cap. The...
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Posted by admin on Jan 31, 2023 in |
Bioremediation of organic compounds and heavy metals has been recognized to be a successful and effective technique in rhizoremediation of soil toxicity using the beneficial microbes which produce different metabolites and enzymes to degrade the toxic compounds/ pesticides available in the soil. In the present study, actinobacterial isolates were explored and identified for bioremediation of soil toxicity available in the soil. The actinobacterial isolates were utilized for the promising PGPR traits and ability to degrade the monocrotophos pesticide residues available in the soil. The “opd” gene of interest responsible for monocrotophos pesticide degradation trait was isolated and cloned in vector DNA to produce recombinant DNA. The recombinant DNA was transformed in E. coli cells to produce multiple copies in E. coli cells resulting in recombinant (transformed) and non-recombinant (non-transformed) colonies. The transformed E. coli cells were inoculated in nutrient broth having pesticide concentration. The transformed cells degraded the pesticide, and the HPLC method determined the derivatives produced. The formulations based on actinobacterial isolates were tested, and field applications were...
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Posted by admin on Jan 31, 2023 in |
Background: Solubility is an important boundary to obtaining the needed drug concentrations in systemic circulation for pharmacological response to be shown. In today’s time, poor water solubility is the crucial issue faced with developing new chemical entities. Objective: Cefixime trihydrate (CT) is an oral third-generation cephalosporin antibiotic used to treat bacterial diseases. It has an oral bioavailability of 40-50% and belongs to the BCS class-IV. This study aims to boost the solubility of poorly aqueous soluble anti-bacterial drug cefixime trihydrate (CT) by the hydrotropic solubilization technique. Methods: Hydrotropy is one of the solubility improvement techniques that enhance the solubility to many folds with hydrotropes. Sodium benzoate (SB) and piperazine (PP) are the hydrotropes that were selected for the preparation of solid dispersion to improve the solubility of cefixime trihydrate. Thus, prepared solid dispersions were evaluated for percentage yield, drug content, saturation solubility and in-vitro dissolution studies. Results: The result showed increased solubility and in-vitro drug release of CT compared to the pure drug. The solubility of cefixime trihydrate was...
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Posted by admin on Jan 31, 2023 in |
Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disorder. It is characterized by inflammation of the synovial joints and concomitant destruction of cartilage and bone. However, rheumatoid arthritis is typically a progressive illness that has potential to cause joint destruction and functional disability. In the present research, GSH content were significantly decreased in arthritic control group when compared to normal control group. Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, causes increase in GSH content, which was comparable with standard drug Dexamethasone. Change in body weight is in response to the incidence and severity of arthritis and used to assess disease onset. Weight loss is associated with increased production of pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1. Adjuvant arthritis is characterized by reduced body weight. The body weight of arthritic control rats decreased compared to the normal control group due to FCA administration. Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, recovered the body weights, significantly which was comparable with standard drug Dexamethasone....
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Posted by admin on Jan 31, 2023 in |
Background: Pityriasis Versicolor (PV) is a cutaneous fungal infection of the skin revealed by changes in skin pigmentation due to colonization by a dimorphic lipophilic fungus of the skin, known as Malassezia furfur. There is an impact on the psychological status of patients resulting in anxiety or depression. This disease is predominant in warm and hot climates. Currently, no ideal drug of choice exists with minimal side effects to treat PV. Objective: To assess the incidence, characteristics of the lesions, and effectiveness of the herbal procedure. Aim: To treat PV individuals with herbal treatment by minimizing side effects. Methods: The herbal cure was chosen based on a preferable study; different types of herbs used are Neem powder, herbal baths, turmeric, and streaming, which helped to clear PV patches present on the skin. The diagnosis is clinical, but a direct examination must be done. The present clinical research study is on the potentiation of the body’s ability to eliminate PV by manipulating the diet and managing lifestyle for PV. Results:...
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