Posted by admin on Jun 30, 2023 in |
Understanding the preponderance of respiratory conditions with the symptoms like sore throat and cough being even more common, owing to the coronavirus outbreak. The improved resolution method was developed to quantify drugs Loratidine and Ambroxol from the most effective dosage regimen to treat sore throat and cough. An accurate, precise method was developed for concurrently estimating drugs from combined tablet dosage form by first-order derivative UV spectrophotometric method. Absorption maxima were determined as 265 nm for Ambroxol hydrochloride (ZCP for Loratadine) and 307 nm for Loratadine (ZCP for ambroxol hydrochloride), using 0.1 N HCl as a solvent for estimation. The analysis results were developed as per ICH guidelines and the drugs obeyed beer lambert’s law in a concentration range of 10 – 125 µg/mL for Ambroxol hydrochloride and 2 – 12 µg/mL for Loratadine with a regression coefficient of 0.9994 and 0.999 respectively. The %RSD values (<2) in precision studies indicate the method’s reproducibility. The LOD values were found to be 1.35µg/ml and 0.37µg/mL, and LOQ values were found...
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Posted by admin on Jun 30, 2023 in |
This entire study is based on the drug delivery system of the pharmaceutical company to design the drugs. In order to identify the effectiveness of the drug, this study has tried to identify the bonds between peptides & proteins. In this context, this study has chosen the drug acetazolamide and based on the chemical properties, it has made a calibration curve of the drugs in water solution. In addition, this study has tried to analyze the recompression factors to identify the percentages of drug release in relevant time...
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Posted by admin on Jun 30, 2023 in |
Marine microorganisms are a valuable source of novel enzymes with ideal characteristics because of the halophilic nature of marine bacteria. The present study aims to isolate, screen, and identify the marine bacterial strains from marine sediment samples that produce an enzyme urease with clinical and industrial applications. Marine sediment samples were collected and cultured on zobell marine agar medium. After incubation seven bacterial strains were isolated from the culture. From this, five isolates were showed urease activity on the urea agar base medium. Morphological and biochemical test of urease-producing organisms was done. Urease-producing bacterial strains (UR S7B) were selected on the basis of their urease test. The selected strain UR S7B was further sequenced for identification. The phylogenetic characterization and 16S rRNA of the strain UR S7B revealed that bacterial cultures belong to Bacillus sp. The morphological studies indicated that the isolate was Gram -ve, rod-shaped and motile organism. The present study concludes that marine bacteria can be a urease source with important...
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Posted by admin on Jun 30, 2023 in |
A cross-sectional study was conducted among 140 study subjects in an urban residential area of East Delhi selected by simple random sampling method to assess the prevalence of self-medication for Covid-19 and associated socio-demographic and economic factors. Data were collected by interviewing the study subjects using a pre-tested semi-structured interview schedule. The Mean+SD age of the study subjects was 41.89+13.54 years (range: 20 to 75 years); 77 (55.0%) were males, and 75.7% were graduates and above. There were 86 with a Covid-19 positivity history. The prevalence of self-medication among them was 33.7% (95% CI: 23.9%, 44.7%), least in 30-39 years (5.9%, 95% CI: 0.1%, 28.7%), maximum in 40-49 years (44.4%, 95% CI: 21.5%, 69.2%) (p=0.101), higher in females (38.1%, 95% CI: 23.6%, 54.4%) than males (29.5%, 95% CI: 16.7%, 45.2%) (p=0.402), socioeconomic class III (52.4%, 95% CI: 29.8%, 74.3%) and least among class I (20.0%, 95% CI: 9.6%, 34.6%) (p=0.017). Self-medication was not associated with education level, working status and marital status. Prevalence of self-medication was high during the...
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Posted by admin on Jun 30, 2023 in |
Introduction: Ultrasound-guided axillary brachial plexus block is commonly used for forearm and hand surgery. Perineural dexamethasone 8mg has proved to prolong the duration of analgesia, but studies with low doses of dexamethasone are scarce. Hence this study was designed to determine the duration of analgesia with 2 mg dexamethasone used perineurally with ropivacaine. Methods: Fifty-Eight patients scheduled for forearm and hand surgeries were included in our study and randomly allocated into two groups. Group R- Axillary Brachial Plexus Block given with 0.75% Ropivacaine 18 ml and 2ml NS and Group RD- Axillary Brachial Plexus Block given with 0.75% Ropivacaine 18 ml and 2 mg Dexamethasone making a total volume of 20ml. Results: Four patients were excluded because of block failure. The time of first rescue analgesia in Group RD was 515.74±11.07 minutes and in Group R was 452.78±14.76 minutes and was statistically significant. Onset of sensory block and motor block in Group RD was earlier than in Group R and duration of sensory and motor block was also longer...
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