Posted by admin on Feb 28, 2023 in |
A study has been undertaken to isolate potent fungi from the South-east coastal zone of Andhra Pradesh. Among the 11 fungal strains isolated and screened, one potent strain with broad-spectrum antagonistic activity was found. Based on the morphological, cultural, and molecular characteristics, the potent strain was identified as Tritirachium egenum. Production of bioactive metabolites by the strain was high in malt extract broth compared to other media tested. The strain utilized mannitol and ammonium sulphate as good carbon and nitrogen sources for the elaboration of antimicrobial metabolites. The optimum pH and temperature for bioactive metabolite production by strain were recorded at 4.0 and 30°C, respectively. The secondary metabolites produced by the strain grown under optimal conditions exhibited high antagonistic activity against Gram-positive and Gram-negative bacteria and fungi. This is the first report of antimicrobial metabolites produced by Tritirachium egenum isolated from the south-east coast of Andhra...
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Posted by admin on Feb 28, 2023 in |
The main aim of present investigation was to examine the potential of a microemulsion formulation developed through simplex lattice design as well as desirability function approach for transdermal delivery of BCS class II anti diabetic drug Glibenclamide. Pseudo-ternary phase diagrams were plotted by water titration method for multiple microemulsion formulations using oleic acid (oil), tween 80 (surfactant) ethanol (cosurfactant) mixture and water. The area of Pseudo ternary phase diagram was the basis of selecting surfactant cosurfactant ratio (i.e. 1:2).Simplex lattice design for microemulsion preparation was used to identify the effect of independent variables oil concentration (X1), scs concentration (X2) and water (X3) with response variables like percentage transmittance (Y1) as well as cumulative % drug permeation (Y2). Polynomial equations as well as model graphs obtained by performing simplex lattice design experiments were used to evaluate the effect of independent variables on responses. The concentration of surfactant cosurfactant mixture was directly related to transmittance and hydration of skin also affected the permeation. So there was significant effect on the responses...
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Posted by admin on Feb 28, 2023 in |
Background: There is a significant link between polypharmacy and the emergence of adverse effects, drug interactions, and increased mortality among elderly patients. Polypharmacy and inappropriate prescription are matters of concern in elderly individuals; therefore, this study was done to find the pattern of polypharmacy among elderly patients. Methodology: A cross-sectional study was carried out at Tripura Medical College & Dr. B. R. Ambedkar Memorial Teaching Hospital (TMC) for a period of 12 months for elderly patients. Polypharmacy was analyzed by counting the number of medications per prescription. Each prescription drug was analyzed for overprescription, under-prescription, and inappropriateness individually. Baseline data were represented by suitable tables & figures and expressed in frequency, percentage, mean & standard deviation. The Chi-square test was applied to find out any statistical association. P value < 0.05 was considered statistically significant. Results: 444 elderly (65 years & above) patients attending medicine OPD were interviewed individually. Our study showed that 36.93% of the patients were receiving polypharmacy. There was a significant association between overprescription or underprescription...
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Posted by admin on Feb 28, 2023 in |
Introduction: The incidence and prevalence of diabetes and its complications has been significantly increased in recent times. C-reactive protein and hyperuricemia are early inflammatory markers associated with type 2 diabetes. Increased uric acid levels are known to be associated with endothelial dysfunction. The relationship between serum uric acid and inflammation in type 2 diabetes has not been explored thoroughly. Aim: The study estimates the levels of High sensitivity (hs) C-reactive protein and serum uric acid in type 2 diabetic patients. To find the correlation between serum uric acid levels and C-reactive protein levels in diabetic patients. Material and Methods: The observational study was conducted on 100 patients suffering from type 2 diabetic patients more than 40 years of age of either sex, coming to the biochemistry lab for investigations for six months. The serum uric acid, hs-C-reactive protein, and fasting blood glucose levels were analyzed. Results: It was observed that hs-CRP was significantly correlated with uric acid (with r=0.276, p-value= 0.005). It was also observed that there was no...
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Posted by admin on Feb 28, 2023 in |
We are in the half past of 2022, but still, we are facing the coronavirus pandemic situation. When a patient is hospitalized, only some FDA-approved drugs were administered to cure the patient. In treating coronavirus infection, nitazoxanide, granulocyte-macrophage colony-stimulating factor inhibitors, and various monoclonal antibodies are present. But all the molecules used in the treatment were not so effective in fully curing the patient. So, to break this jinx to develop of newer generation anti-SARS-CoV-2 drug molecules, computational approaches played an essential role. 2D QSAR studies related to anti-SARS-CoV-2 molecule development, some QSAR models observed with good statistical parameters such as R2: 0.748, cross-validated Q2 (LOO): 0.628, external predicted R2: 0.723 and another model suggested with R2: 0.764, Q2: 0.627 and Rm2: 0.610, Q2 (F1): 0.727, Q2 (F1): 0.652, MAE score: 0.127. We developed a new 2D QSAR model with a higher number of molecules and greater statistical parameters. A dataset of 84 anti-SARS-CoV2 molecules was obtained from literature followed by descriptor calculation PADEL software; the QSAR model was...
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