Posted by admin on Dec 31, 2022 in |
In the present study, the antioxidant and anti-microbial potential of aerial and underground parts of the Cardaria draba (L.) Desv. Different tests evaluated methanolic extracts. The phenol and flavonoid contents of the extracts were investigated by Folin Ciocalteu and AlCl3 assays. Phenolic compounds analyzed By HPLC method. DPPH Radical-Scavenging, reducing power, nitric oxide-scavenging, and Fe2+ chelating tests were used to measure antioxidant activity and evaluate anti-microbial properties MIC, MBC, and ZOI values of extracts were measured. Extracts contained significant amounts of phenols and flavonoids. In the HPLC analysis, chlorogenic and a suitable mobile phase separated coumaric acid peaks. IC50 of DPPH Radical-Scavenging Activity for the aerial part was 403 ± 2.3 µg ml-1 and for the underground part was 555 ± 3.1 µg ml-1. Extracts showed weak reducing power that significantly differed significantly with Vitamin C (p <0.01). In the case of the nitric oxide-scavenging effect, quercetin activity was much more than in both extracts. Also, extracts had a weak capacity for Fe2+ chelating activity. The MIC values for...
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Posted by admin on Dec 31, 2022 in |
In this study, a series of novel Synthesis of (2,4-dimethoxy-3-((3- phenyl-4, 5- dihydroisoxazol-5-yl) methoxy) phenyl) (phenyl) methanone (8a-p), were synthesized from condensation of an equimolar quantity of aryl (3- hydroxy-2, 4-dimethoxyphenyl) methanones (4a-d) and 5-(bromomethyl)-3- phenyl-4,5-dihydroisoxazole (7a-d) in DMF solvent by employing anhydrous potassium carbonate (K2CO3) as a base. The chemical structure of the newly synthesized compounds was characterized by analytical and spectral (1HNMR, 13CNMR and HRMS) techniques. The desired title compounds were screened for qualitative (zone of inhibition) analysis by agar well method, respectively. Among the synthesized compounds in the series, the compounds 8b, 8c, 8f and 8l were found to show major antibacterial activity at a lower concentration, against Gram-positive bacteria such as Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria such as Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The rest of the compounds exhibited ample antibacterial activity compared to Chloramphenicol’s standard positive...
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Posted by admin on Dec 31, 2022 in |
The present study has been conducted to search out the anti-oxidative and anti-inflammatory potential of leaves of Camellia sinensis L. oil (Tea oil, TO). Forty-eight rats were included for 14 days experiment namely: Group I was normal to control, Group II was vehicle control, and Group III to VIII rats were subjected to paracetamol at the dose of 15 mg/ kg body weight/day to induce oxidative stress and inflammation (OS and I rats). Group IV to VII rats orally received TO at the dose of 100, 200, 400, 800 mg/kg, respectively and Group VIII received olive oil at 400 mg/kg. Paracetamol causes a significant (p < 0.05) increase in plasma urea, creatinine, glutamine-oxalic-transaminase, glutamate-pyruvate-transaminase, alkaline-phosphatase, interleukin-18 and tissue-injury-molecule-1, malondialdehyde and degeneration of hepatic cells in case of only OS and I rats. But treatment with TO in different doses showed a significant (p < 0.05) decrease above said parameters. We observed a significant (p < 0.05) decrease in superoxide dismutase, catalase, interleukin-10 levels in OS and I rats and...
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Posted by admin on Dec 31, 2022 in |
Gradual vision loss is linked to degenerative changes and cataract. The Isotine-herbal eyedrop has been clinically used for 36 years with a claim to reverse the cataract-induced visual impairment. This retrospective observational study on 308 cataract patients, registered between 2017 to 2019 at Basu Eye hospital, Bareli, UP, India, having 3 months of treatment, shows the significant therapeutic response in uncorrected distance visual acuity (UDVA) based on logMAR mean before and after treatment (P<.001). The improvement has been observed in patients having UDVA 0.1 to 1.7 and in UNVA from N-6.1 to N-36and above. Patients of partial vision impairment, having logMAR up to 0.99, significantly attained either normal vision or below 6/18 (logMAR- 0.47). In 103 patients of severe vision impairment (logMAR mean 1.0 to 1.77, considered as Blind by WHO), only 40 patients did not respond, but the remaining 63 patients attained a logMAR mean below logMAR-0.8. In the case of UNVA, 169 patients had vision between N-12 to N35, but after treatment, either they got normal vision...
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Posted by admin on Dec 31, 2022 in |
Plants and plant-based medicaments are the basis of many of the modern pharmaceuticals we use today for our various diseases. Pterocarpus santalinus Linn (Fabaceae) is a small to the medium-sized deciduous tree is widely distributed in the tropical regions of the world. The plant is mainly used to cure skin ailments, cough, hyper nervous activity and is also used as an anti-inflammatory, anti-cancer, and hepatoprotective agent. The present study aimed to determine qualitative and quantitative phytochemical and in-vitro antioxidant activities of the leaf of P. santalinus. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenol and flavonoids were determined by the well-known test protocol available in the literature. Quantitative analysis of phenolic and flavonoids was carried out by Folins Ciocalteau reagent and aluminum chloride methods, respectively. The in-vitro antioxidant activity of hydroalcoholic extract of the leaf was assessed against the DPPH assay method using standard protocols. Phytochemical analysis revealed the presence of flavonoids, diterpenes, phenol, protein, saponins, and tannins. The total phenolic and flavonoid content of...
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