Posted by admin on May 31, 2023 in |
The Cultivation of Abelmoschus moschatus plants for collecting seeds used for medicinal purposes is affected by Mycotoxins which are substances that moulds create under particular environmental circumstances. These pollutants harm both human and animal health. Mycotoxins are difficult to get rid of and are occasionally impossible. The best control is prevention. Controlling the moisture levels in herbal materials and storage conditions like temperature and/or relative humidity can help avoid the growth of mycotoxins. The different parameters like Harvesting season, Dry grain storage conditions, and crop rotation techniques affect the growth of the mycotoxins. In this trial, the plants are grown using different parameters affecting the production, the packaging material and storage conditions are also varied as per QBD approach and the level of mycotoxins, specifically aflatoxins (G1, G2, B1 & B2) are identified, quantified, and monitored. The Aflatoxins are identified and analyzed using the HPLC-FLD technique, a sophisticated method for estimating the aflatoxin content in ppb levels; the method is validated and provides accurate and precise results in the...
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Posted by admin on May 31, 2023 in |
A highly sensitive, simple, accurate and precise Ultra high-performance liquid chromatographic (UHPLC) method was developed and validated for the quantitative determination of sofalcone in the presence of its degradation products. The analysis was performed on Agilent symmetry analytical column Eclipse plus C18 (100mm × 2.1 mm, 1.8μm) ultra-performance liquid chromato-graphy-Diode Array Detectors (UHPLCDAD), while the detection was performed on 350 nm using Diode Array Detectors. Water (0.1% Formic Acid) and Ammonium Acetate in Methanol were the mobile phases, run at a flow rate of 0.3 ml/min for gradient elution. The mean values of recovery were found to be 100.02% and 100.55%. The linear regression data for the calibration plot showed a good relationship with high correlation coefficients. The performance of the method was validated for precision, accuracy and robustness. Sofalcone was subjected to the ICH-prescribed acidic, alkaline, oxidative, photolytic, and thermal stress conditions, and it undergoes degradation with well-resolved degradation products. These degradation products were further analyzed by mass spectrometry to elucidate the structure of degradation products and proposed...
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Posted by admin on May 31, 2023 in |
Infectious diseases continue to be a major cause of morbidity and mortality, and the current antimicrobial resistance crisis has the potential to worsen this problem. To address this issue, new antimicrobials and strategies for fighting antimicrobial resistance are needed. In this study, we synthesized two arylflouro hydrazide derivatives by reacting various selected hydrazides (4-Fluorobenz-hydrazide) and different substituted aromatic aldehydes (3-Bromo-2-fluoro benzaldehyde and 5-Bromothiophene-2-carboxaldehyde). The compounds were characterized using IR, 1H NMR, and 13C NMR. The synthesized derivatives were also pharmacologically evaluated using molecular modeling. The biological activity was assessed using an antimicrobial assay, which showed significant activity compared to the standard Ampicillin. Among the synthesized compounds, PD2B exhibited a higher zone of inhibition with 10 mm in E. coli and 12 mm in B. subtilis, whereas PD2F showed a zone of inhibition with 3 mm in E. coli and 8 mm in B....
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Posted by admin on May 31, 2023 in |
Purpose: Sanshamani Vati (SHV) is useful in all types of Jwara, and Mahalaxmivilas Rasa (MLVR) is the best drug in various cardiovascular and respiratory disorders. To maintain the enormous trust in Ayurveda, it’s necessary to ascertain the quality, efficacy & safety of Ayurvedic formulations on scientific lines using modern techniques. Present work attempts have been made to standardize the traditional Ayurvedic formulations – SHV and MLVR with modern techniques. Method: The formulations were standardized for physicochemical, Elemental and phytochemical screening. The XRD profiling was done for MLVR. Also the authentication of RM used in SHV was done using HPTLC. The validation of the methods for Elemental and phytochemical assays was performed as per ICH guidelines. Results: The Physico-chemical and phyto-chemical screening of Sanshamani Vati, and Mahalaxmivilas Rasa Tablets was done. The HPTLC profile confirms the presence of Berberine at Rf 0.25 ± 0.02 in SHV and Myristicin at Rf 0.50 ± 0.02 in MLVR. The elemental content of Gold (Au), Iron (Fe), Mercury (Hg) & Copper (Cu) in MLVR...
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Posted by admin on May 31, 2023 in |
Siddha medicine originated from Tamil culture in southern India. Worldwide there are 75% of herbal plants are used for AYUSH and Allopathy medicines. Amukkara Choornam is a polyherbal Siddha formulation. Amukkara Choornam has anti-arthritic activity, and it helps to cure rheumatoid arthritis. The demand for Siddha medicines in India is increasing daily; we have to overcome some problems like quality control issues, processing, administrative issues, and clinical trials. From the above, quality control issues are the most important ones. The quality, safety and, side effects, knowledge about herbs can be determined while standardizing each herbal formulation. The knowledge about the herbs and herbal medicines by the villagers and tribes is unknown to scientists. Scientists are well-known about the standardization process unknown by rural peoples and tribes. Hence the present study is carried out to identify the bioactive phytochemical constituents present in Amukkara Choornam by spectroscopic analysis. Standardization is a tool in the quality control process must for rural health care. Siddha medicines are our traditional medicines, which have lesser...
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