Posted by admin on Nov 30, 2022 in |
Cutaneous wound healing starts with an acute inflammatory phase marked by secretion of pro-inflammatory mediators that enhance infiltration of leukocytes with a peak in the first 24 to 48 h. This resolves to enable the continuation of other phases in series, namely, the proliferative, re-epithelialization, vascularisation, and tissue remodelling phases. The study uses a mechanical device, for the first time, to create a mechanical cutaneous wound in adult Zebrafish to simulate mammalian cutaneous wound. Topical application of 0.5% ointment of a fraction from hexane leaf extract of Vernonia arborea, accelerated wound healing in the developed model. The phytocompound in the fraction modulates the inflammation kinetics, increasing initial inflammation at 24 hrs by expediting neutrophil infiltration, three folds more than the untreated model. The resolution of inflammation was rapid in the experimental group after 3 dpw compared to the untreated control resulting in speedy proliferation and migration of keratinocytes and three times faster wound closure, measuring up to 92.3% as compared to 95.3% in the positive control group. The fraction...
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Posted by admin on Nov 30, 2022 in |
Bryophytes are the closest modern relatives of the predecessors to the earliest terrestrial plants and have shown to be brilliant chemists since they have long been a favorite treatment among tribal peoples all over the world, who use its pharmacological characteristics to treat a wide range of ailments. As bryophytes’ Phytochemistry contains a diverse range of biologically active compounds such as lipids, proteins, steroids, organic acids, alcohols, aliphatic and aromatic compounds, polyphenols, terpenoids, acetogenins and phenylquinones, it’s no surprise that substances derived from these ancestral plants are widely used as antitumor, antipyretic, insecticidal and antimicrobial agents. The present investigation has been an attempt to evaluate the antifungal potential of two ethnic botanically important liverworts, Plagiochasma appendiculatum, and Pellia endiviifolia. The methanolic extract was tested against two fungal species, Candida albicans MTCC 1637 and Aspergillus niger MTCC 1235. In-vitro antifungal activity was evaluated by disc diffusion method, which revealed inhibition of Candida albicans MTCC 1637 and Aspergillus niger MTCC 1235 growth. Plagiochasma appendiculatum proved to be more effective against both...
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Posted by admin on Nov 30, 2022 in |
Background: Severe Acute Respiratory Syndrome Corona Virus Disease 2019 (COVID-19) is responsible for the COVID-19 pandemic causing respiratory illness worldwide. Hence there is an urgent need for simple, rapid, and accurate tests for diagnosis. Performance characteristic of Rapid Antigen detection test for identifying sensitivity and specificity with gold standard Real-Time Polymerase Chain Reaction and correlate the significance of non-specific parameters like CRP(C- Reactive Protein), IL-6(Interleukin-6), Procalcitonin for diagnosis of COVID-19. Methods: The Rapid Antigen Detection test was compared with Real-Time Polymerase Chain Reaction to detect SARS CoV-2 in respiratory specimens. 100 respiratory samples (mainly nasopharyngeal and throat swab) and for CRP, IL6, and Procalcitonin serum samples were obtained from COVID-19 suspected cases, mostly in-patients at Saveetha Medical College from April 2021- to September 2021. Results: Out of 100 samples, 67% were positive, 33% were negative for SARS-CoV2 RNA by RT-PCR assay. When compared with Rapid Antigen Test, the RT-PCR test showed 83.8% sensitivity and 59.3% specificity, while non-specific parameters correlation in diagnosis of COVID-19 showed CRP insignificant, IL-6 and...
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Posted by admin on Nov 30, 2022 in |
Background: Fever is a part of a complex biological response due to pathogens, bacterial infection, damaged cells, drugs, toxins, etc. Fever is currently treated by NSAIDs. Unfortunately, NSAIDs damage the liver and kidney, inhibit COX-1, which affects the digestive system, and increase the risk of a blood clot. Therefore, the developments of potent antipyretic drugs from medicinal herbal plants are now under consideration. Polyherbal formulations (PHFs) was become resurgent due to the demand and consumption of herbal drugs. The present research aims to evaluate the antipyretic screening activity of PHFs in albino Wistar rats. Material methods: Different PHFs combinations were formulated using hydro-alcoholic extracts and explored the antipyretic activity of PHFs in albino Wistar rats. Male albino Wistar rats weighing 100-150g were selected and grouped among normal control, standard (Paracetamol; 150mg/kg) and treatment groups (PHF; 100 mg/kg, PHF; 300 mg/kg and PHF; 600 mg/kg) respectively. To check the safety parameters of PHFs extract, Hematological and biochemical tests were also performed. Results: PHFs (100mg/kg, 300mg/kg and 600mg/kg) shows antipyretic effect...
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Posted by admin on Nov 30, 2022 in |
Ibuprofen is a Non-steroidal anti-inflammatory (NSAID) class drug and is used to treat pain, minor aches, fever, inflammation, and arthritis. Ibuprofen has an oral dose of 300 mg minimum and 3200 mg maximum in a day and is the main reason for the increase in its dosing frequency; many of the Ibuprofen formulations are of three times a day dosing and is the main reason for the development of such a formulation which can reduce the dosing frequency, so many researchers developed Ibuprofen matrix dosage form which can give a prolonged therapeutic effect. But in this formulation, Ibuprofen is combined with a Natural, Resinous substance known as “Bee Propolis” or simply “Propolis” Propolis is a natural substance collected by some species of Honey bees; it is a resinous, gummy material that has many therapeutic properties and can also be used as a natural binder in the dosage form due to its good binding abilities and, it can also give a positive synergistic effect when combined with Ibuprofen. In this...
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