Posted by admin on May 31, 2023 in |
In the present investigation, newly developed solid dispersion technology that precludes the use of organic solvent and decreases the individual concentration of hydrotropic agents, simultaneously decreasing their toxic potential, was employed for preparing dispersions of valsartan. Valsartan is a pro-drug which has poor bioavailability because of poor solubility as it belongs to BCS class II. Study aims to enhance the solubility of valsartan by mixed solvency approach. Solution was made by using different co-solvents to enhance the solubility of valsartan. Camphor, thymol were used as solvents to increase the solubility of valsartan. A mixture of camphor: thymol (1:1) was selected for solubility enhancement of valsartan. FTIR study did not show any interaction between drug and excipients. Prepared solid dispersions were evaluated for flow properties, XRD, DSC, and SEM were also compressed to form tablets. Dissolution studies of prepared tablets were carried out using USP Type II Apparatus. The stability study for up to one month showed no significant changes by evaluation parameter. It was concluded that the concept of...
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Posted by admin on May 31, 2023 in |
The epidemic of COVID-19 provides various issues for healthcare professionals. Rapid assessment and treatment, vulnerability classification, efficient use of critical care facilities, adequate medications, surveillance, and prompt discharge, are crucial to protect as many casualties as possible. We described different classification techniques of ML (machine learning) to analyze skin-related issues. This research aims to provide adequate skin specialists with a strategic plan to understand that they may diagnose its prospects and problems. In this work, we use well-known ML methods, including DT (Decision Tree), LR (Logistic Regression), SVM (Support Vector Machines), KNN (K Nearest Neighbor), and multi-model (Gradient, gaussian nave bias, XGB, SGD), classification methods. Make an intelligent diagnostic assistant to correctly identify a certain kind of allergy...
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Posted by admin on May 31, 2023 in |
Antibacterial activity of methanolic extracts of different parts (leaves, flowers, green pods and roots) of Moringa oleifera plant were evaluated against gram positive bacteria Bacillus subtilis (Bs), Staphylococcus aureus (Sa) and gram negative bacteria Klebsiella pneumonia (Kp), Escherichia coli (Ec), Pseudomonas aeruginosa (Pa). The activities were performed by the agar well diffusion and cup plate method, with methanol as the negative and tetracycline as a positive control. Secondary metabolites extracted from all the parts of M. oleifera were found active against bacteria. Furthermore, the antimicrobial activity of the mentioned plant extracts was also examined against various gram-positive and gram-negative bacterial strains. It was observed that against K. pneumonia, leaves extracts (17.6 mm) of M. oleifera possess higher antibacterial activity as compared to others, flower extract (19.2mm) against B. subtilis, leaves extracts (22.6 mm) more effective against E. coli, pod extracts (22.5 mm) against S. aureus and leaf extract (21.9 mm) showed against P. aeruginosa as compared to others. The results reveal that M. oleifera might be a potential source...
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Posted by admin on May 31, 2023 in |
The continuous search to search for a naturally occurring medicinal compound that could be a suitable adjunct to existing therapies for treating one of the growing global health emergencies in diabetes is a never-ending one. Naringenin [2, 3-dihydro-5, 7-dihydroxy- 2 -(4-hydroxyphenyl) -4H-1-benzopyran-4-one], a naturally occurring flavonoid abundantly present in grapes, grapefruit, and citrus fruits have been found to confer different pharmacological activities. Thus, keeping its potential medicinal properties in mind, our aim of the study was an in-depth study of intraperitoneal treatment of naringenin, especially at the levels of oxidants, lipidemic activities, and anti-apoptotic activity in tissues such as the heart and brain, so that it could be better evaluated as a potential therapeutic agent. Our study demonstrates that naringenin treatment reduced hyperglycemia-inducedoxidative stress by activating various intracellular anti-oxidant enzymes and preventing apoptosis by initiating the translocation of Bcl-2 to the mitochondria, partially affecting the release of mitochondrial cytochrome c to the cytoplasm and preventing the activation of caspase-3 and caspase-9, thus preventing cell death. The transmission electron microscopic...
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Posted by admin on May 31, 2023 in |
Leukemia is a disease of cancer that affects blood-forming tissues i.e., bone marrow and lymph nodes, which is associated with uncontrolled growth of WBCs. These cells are unable to fight against infection and weaken the ability of bone marrow to make RBCs and platelets. When leukemic cells overproduce, they interfere in circulatory cells’ functioning, i.e., RBCs and platelets. Along this, leukemia’s pathogenesis is unique in relation to different malignant growths which ordinarily start in major organs and then spread in bone marrow. Different types of leukemia are discovered based on different classification systems with the two major leukemia types – acute and chronic. The work includes the 50-year history of leukemia-lymphoma cell lines, which is considered a key model system in biomedicine. The work involves finding suitable protein receptors for the available potent drugs. Protein receptors are the target sites where drug molecules bind, activate and start their response. FLT3 tyrosine kinase protein is taken as a receptor to study docking concerning ligands like Abacavir, Gabapentin, etc. Autodock and...
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