Posted by admin on Nov 30, 2022 in |
Maṇikkaṭai-nūl (MK) is an exclusive diagnostic method particular to Siddha Medicine, where the subject’s Finger breadths (FB) calculated from the Antebrachial circumference (ABC) is accessed for predicting the symptom, disease, or the pathological sequence. The present observational field studies (Study 1 & 2) aim to validate the clinical significance of MK as a reliable diagnostic tool. True positive (T+), False positive (F+) and False negative (F-) predictions were evaluated in study 1 (n=116). Three divisional trials were done in study 2 that assessed the correlation of MK readings with Antebrachial circumference (ABC) (n1=117), ABC, total fingerbreadth (TFB) (n2=27), and Body Mass Index (BMI), and ABC. (n3=23). Pearson correlation analysis was used to determine the association between different parameters based on a 95% confidence interval. The differences were considered significant at a P-value of <0.05. A Scatter plot was used to study the pattern of association. From the study (n =116), the T+ cases were 97 (83.62 %) and 16 cases (13.79%) were not relevant (F+ & F-). For the...
Read More
Posted by admin on Nov 30, 2022 in |
Introduction: Plantar fasciitis is one of the more common causes of pain in the heel, as seen in non-traumatic patients. When the conservative treatments fail, Corticosteroid injection and Autologous Platelet Rich Plasma (PRP) injection will provide good pain relief. The study was performed to compare the functional outcomes following PRP and steroid injection and to identify which modality provides better pain relief. Materials and Methods: This was a prospective study of 30 patients. Patients were allocated to 2 groups, Group A(n = 15) and Group B(n=15). PRP injection was given in group A and Corticosteroid injection was given in group B. Visual Analog scale (VAS) and American Orthopaedics Foot and Ankle Society (AOFAS) score were used for assessing the pain and functional outcome. Results: In group A: the mean VAS pre-PRP was 6.66, which improved to 1.13 at the 6th-month follow-up. The mean AOFAS score pre-PRP was 62.8 and was improved to 89.20 at the 6th-month follow-up. In group B, the mean VAS pre-steroid injection was 6.8, which improved...
Read More
Posted by admin on Nov 30, 2022 in |
Nanoparticles are fascinating materials that find many applications in basic and applied research. The chemical reduction technique is one of the easiest methods for synthesizing Nickel Oxide Nanoparticles (NiO NPs) in low-temperature ranges. Nickel Nitrate Hexahydrate (Ni(NO3)2.6H2O), Ascorbic acid, NaOH, and NaBH4 were applied as starting reagents to synthesize NiO NPs. Noble metal oxide nanoparticles have been extensively utilized for many applications in the present scenario. In the present study, attention has been focused on the fabrication of NiO NPs synthesized by the Chemical Reduction Method (CRM). The synthesized nanoparticles were characterized by UV-Vis spectroscopy, FTIR spectroscopy, X-ray diffraction, EDAX, and SEM Techniques. The optical band gap energy value has also been determined as 2.59eV from the UV-Vis spectrum. The nanometal oxide is subjected to photocatalytic activity on Congo red dye under solar irradiation and exhibits very good degrading ability within a few minutes of exposure. Its pharmacological activity is also analyzed using pathogenic organisms like Staphylococcus aureus, Bacillus subtilis, Escheria coli, and Pseudomonas aeruginosa bacteria and found to...
Read More
Posted by admin on Nov 30, 2022 in |
Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the reported ADRs were analysed. Results: 150 suspected ADR reports were collected. Adult patients (14-50 years) experienced 109 (72.66 %) ADRs followed by elderly patients (>50 years) experienced 29 (19.33%) ADRs and paediatric patients (<14 years) experienced 12(8%) ADRs. On the causality scale 62.67% were probable ADRs and on severity scale 63% were moderately severe ADRs. According to MeDRA classification of ADR, Skin and subcutaneous tissue disorders were most common (47.67%), followed by Gastrointestinal disorders (23 %) and Nervous system disorders (13.95%). ADRs were most commonly seen due to antimicrobial drugs (44.3%) followed by Non steroidal anti-inflammatory drugs (NSAIDs) (17.8%). Conclusion: Our study findings showed underreporting in spontaneous ADR reporting system. Continuous efforts through...
Read More
Posted by admin on Nov 30, 2022 in |
Phage therapy has become a successful alternative to conventional antibiotic therapy due to the increasing number of multidrug-resistant bacteria in most clinical settings. Various factors like phage adsorption to the host site and phage neutralization by the host determine the efficacy of phage treatment. However, external factors like temperature and pH are critical in deciding the success of using phages in therapeutics. The high stability of phages under both favourable and unfavourable conditions guides their stability in phage therapeutic preparations as well as at the site of infection. In the present study, we exposed the phage to different pH and temperature combinations. The phage showed statistically significant activity at pH 7 and 8 compared to pH 6. In terms of different exposure temperatures, the phage showed good antibacterial activity at temperatures between 31 0C and 40 0C. A combination of pH 7 with temperature 380 C showed the highest recovery of the phage; however, stability was seen in a considerable range of temperature and pH. The lytic activity of...
Read More
