Posted by admin on Nov 30, 2022 in |
Rungia parviflora belongs to the family Acanthaceae (Linn.). The dried and powdered leaves were extracted with ethanol in Soxhlet’s apparatus for 12 hrs. The extract was subjected to toxicity studies at the doses of 5, 50, 300, and 2000 mg/kg under the observation of 24 hrs. An acute toxicity study of ethanolic extract was found to be toxic (1/2 of rats died) at a dose of 2000 mg/kg, orally. Hence, it was taken as LD50. Further, the hepatoprotective activity of Ethanolic extract at the dose level of 250mg/kg and 500 mg/kg ware studied in Wistar male rats against thioacetamide (400mg/kg p.o.) induced hepatotoxicity. Silymarin 100mg/kg p.o. was taken as a standard hepatoprotective drug. The hepatoprotective activity was studied by determining the parameters like SGPT, SGOT, Total Bilirubin, ALT, Pentobarbitone induced sleeping time, Ascorbic acid content in urine, in-vitro Bromsulphalein uptake test and Histopathological observation of liver. Overall study indicated that ethanolic extract of leaves of Rungia parviflora at a dose level of 250mg/kg and 500mg/kg significantly protects the liver...
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Posted by admin on Nov 30, 2022 in |
Since ancient times, man has been looking for plants to rescue from diseases and improve immunity. He may find the right choice of plants by trial and error, observing nature and following theories, and passing that information to the next generation by word of mouth. Folklore medicine combines traditional healing practices, spirituality, and therapies to diagnose and prevent ailments. In the present study, a survey was carried out about the traditional usage of medicinal plants in herbal healers, old and native peoples of Pathinettamkottai village, and its surrounding areas of Sivagangai district in Tamil Nadu. The study explored 65 medicinal remedies from plants used to treat 41 different illnesses. The predominant part used to prepare medicines is a leaf. The medicines are prepared in the form of powder, paste, decoction, and vapor, and they are used to cure 31 health problems like cold, fever, asthma, diarrhoea, diabetes, jaundice, rheumatism, wounds, cuts, stomach pain, etc., The survey provides rich source of knowledge on plants and, thus new...
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Posted by admin on Nov 30, 2022 in |
The effect of many plant extracts and microbial biopesticides on insects’ different developmental stages and physiology have been widely studied from time to time, but the effect of microbial biopesticides on the mosquito tissues, especially mid gut tissues, is very few. Since the malaria vector is one of the most important inclusions in human health and mosquito-borne diseases represent a great health threat in tropical and sub-tropical climates, it is quiet logical to know the detailed mode of action of fungus on Anopheles stephensi (L.) larvae after assessing the bio toxicity. In the present study, we have mainly emphasized the midgut of Anopheles stephensi (L.) to understand better the larvicidal action of fungal biopesticide Beauveria bassiana (Balsamo). After treatment with the fungus Beauveria bassiana (Balsamo), the cytopathic effects of the fungus were widespread along the whole anterior and posterior part of the midgut...
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Posted by admin on Nov 30, 2022 in |
Purpose: The goal of this study was to develop taste-masked orally disintegrating tablets of the bitter-tasting levocetirizine dihydrochloride (LCDH) to improve the accessibility and adherence of pediatric, elderly, non-cooperative and paraplegic patients. Methods: In the present study, orally disintegrating Levocetirizine dihydrochloride tablets were formulated by direct compression. Taste masking was achieved using a pH-independent polymeric dispersion of Surelease E-7-19040 in combination with Opadry YS-1-19025-A in different ratios. In-vivo taste evaluation was done to see if the tablets produced utilizing the direct compression approach were successfully disguised. Results: The present study investigated uncoated and coated drug substances and prepared tablets of coated LCDH for flow as well as compression behaviour, Fourier Transform Infrared absorption spectra, Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy and in-vitro dissolution and disintegration properties. Conclusion: Using a combination of two polymeric dispersions “Sure lease E-1-19040” and “Opadry” coating for the delivery of LCDH, it was shown that a taste-masking evaluation could be performed to identify effective polymer-carriers for the...
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Posted by admin on Nov 30, 2022 in |
Introduction: SSI (Surgical site infection) is the dreaded complication following orthopaedic surgery. The main source of surgical site infection is the patient’s own skin flora. So skin preparation plays a major role in preventing the SSI. This study aims to compare povidone-iodine and 2% chlorohexidine alcohol in pre-operative skin preparation in elective orthopedic surgery and followed uo for 4 weeks for and postop SSI. Methods:This was a prospective study of 30 patients who underwent elective orthopaedic procedures between October 2021 to November 2021 with a follow-up duration of 4 weeks. A group of 30 patients of both sexes, different age groups with associated co-morbidities were included in our study. Results: They were divided into 2 groups of 15. Group-1 consisted of 9 males and 6 females; their mean age was 51, of which 9 had associated co-morbidities. Group-2 consisted of 8 males and 7 females. There were statistical differences (p<0.05) between co-morbidites in both groups and no statistical difference in risk factors between the two groups in terms of...
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