Posted by admin on Jan 31, 2023 in |
Medicinal herbs have an important role in illness prevention, and their promotion and usage are compatible with all current disease preventive techniques. Pueraria tuberosa, widely known as kudzu, is a climber with tuberculated woody stems. It has exhibited Cardio-tonic, Aphrodisiac, Abthyperglycemic Galactogogic, and anti-lipidemic characteristics Daidzin, Puerarin, Puerarone, Genistein, Puetuberosanol, Tuberostan, Tuberosin and Puerarin 4′,6′ diacetate are all found in high amounts in the tubers of Pueraria tuberosa. Numerous bioactive phytochemicals, mostly Isoflavonoids such as Puerarin, Genistein, Daidzein and Tuberosin, were soon identified in the tuber. In the present study, three types of studies, Pharmacognostical Studies, Phytochemical Studies, and Pharmacological Studies, have been done using methanolic extracts of tuber powder; Pharmacognostical Studies include organoleptic evaluation, microscopical evaluation, and physical evaluation. In pharmacological studies, analgesic activity was recorded using the Hot plate Method. A suitably designed transverse section of the tuber was studied and different tissue organizations were viewed at 10x and 40x. Foreign organic matter, ash values, extractive values, moisture content, swelling index, and foaming index were all measured,...
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Posted by admin on Jan 31, 2023 in |
Background: Caesalpinia bonducella F. (Leguminosae) has long been used in traditional medicinal treating methods. It has high therapeutic values in India Ayurveda. They contain tannin, saponins, flavonoids, and alkaloids. The seeds of Caesalpinia bonducella are claimed to be styptic, purgative, anthelmintic and cures inflammations. Today the interest in traditional medicine and demand for more plant-based drugs has increased. Here the study is focused on anti-inflammatory efficiency and analysis of phytochemical compounds from the Caesalpinia bonducella seed kernel extract. As part of the immune response, inflammation plays a significant role in defending or protecting the body against pathogens like viruses, bacteria, fungi, and other parasites. Inflammation leads to a complete detriment at the sites of inflammation and promotes the renewal or regeneration of normal tissues. During inflammation, Chemotaxis is the event with cells like Fibroblasts, leukocytes, Macrophages, and Tumor cells are involved in the migration of cells towards a chemical signal in the cell’s surrounding environment. Our research focuses on unravelling the anti-inflammatory efficacy of ethanolic fraction, which comprises the...
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Posted by admin on Jan 31, 2023 in |
During the severe worldwide pandemic caused due to SARS COV-2 Corona virus, Favipiravir has been used for the treatment. It is a water insoluble anti-viral drug with poor dissolution and poor flow properties, resulting in poor oral absorption and less bioavailability. For a long time, the phrase “direct compression” was used to describe the compression of a single crystalline component into a compact without the addition of any other materials. Using excipients and solvents, the crystallo-co-agglomeration process aggregates drug crystals in the form of small spherical particles to create an intermediate product with better micromeritic and mechanical characteristics, solubility, and dissolution. Crystallo-co-agglomeration is a unique approach in which the pharmaceuticals or excipients are crystallized and agglomerated concurrently from a good solvent and/or bridging liquid by adding a non-solvent. The present study aims to formulate crystallo-co-agglomerates of Favipiravir to improve its physicochemical and mechanical properties. Results obtained during the evaluation showed that CCA technique could be successfully employed as an alternative to conventional wet...
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Posted by admin on Jan 31, 2023 in |
Potentially bioactive tetradentate novel Schiff base ligand and its mononuclear metal (II) complexes have been synthesized by the condensation method of p – nitroaniline, isatin, and 2, 2′ bipyridyl molecules in the ratio of 1:1:1. The ligand and its reported complexes exactly categorized by diverse physicochemical techniques that include elemental analysis, conductance measurements, IR, electronic spectra studies, 1H NMR spectroscopy, and EPR studies. Derived complexes are exactly non-electrolyte in nature in Dimethylformamide solution because of their lower conductance values. The IR data tells us the association of C=N nitrogen atom in coordination to the metal ion. Electronical studies and magnetic measurements suggested the octahedral geometry around metal ion under investigation. The EPR spectral data shows additional proof for the octahedral geometry. The nucleolytic cleavage of the reported compounds was checked upon pUC18 DNA by gel – electrophoresis method. In this study, anti-oxidant and anti-microbial activities have also been evidently studied. The compounds show exact growth inhibitory activity over bacteria such as S. aureus, E. coli, B. subtilis and K,...
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Posted by admin on Jan 31, 2023 in |
Purpose: A serious cause of morbidity and mortality, malaria remains a major public health concern. Failure of available treatments due to the rapid emergence of drug-resistant parasite strains emphasizes the need for a continuous search for new, safe, accessible, and affordable drug treatments. Methods: In this context, an ethnobotanical survey was conducted, different parts of seventeen medicinal plants were collected, and their methanolic extracts were prepared. These extracts were evaluated for anti-plasmodial activity against two strains of Plasmodium falciparum: chloroquine-sensitive 3D7 and resistant INDO using SYBR-Green I assay. The extracts were also assessed for cytotoxic effects against HEK293 mammalian cell lines using MTT assay. Results: Two plant extracts: Albizia lebbeck and Tecomella undulata exhibited good activity with IC50 ranging from 10-20µg/ml. Among others, eight showed moderate activity (IC50= 20.1- 50µg/ml), while eight extracts either showed poor activity or were not active upto IC50=100µg/ml against Pf3 D7. The extracts with good to moderate effects showed equipotent effects against Pf INDO and were non-toxic to mammalian cell lines with selectivity indices...
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