Posted by admin on Aug 31, 2022 in |
Natural products can be the alternative of synthetic medicine and antiviral drugs can be potential from natural products. An attempt was made to evaluate the antiviral activity from the extract of Desmodium gangeticum (L.) DC. as a phytomedicine (GanjhuVirR) for the treatment of dengue fever associated with thrombocytopenia. The present study was evaluated acute and subacute toxicity in rat as well as clinical trial in treated and without treated patients who admitted in hospital due to dengue fever associated with thrombocytopenia. The rats were grouped into group 1 (control) and 2, 3 and 4 (treated) for toxicity test while 51 patients were included in the clinical trial and 25 were treated and 26 provided only standard management as control. The parameters viz. platelet count, fever profile, average hospitalization period, clinical profiles and viral load reduction were tested for both the group. All the data related to morbidity, mortality and behavioural features were observed similar between exposed and control group. The haematological and biochemicals findings were comparable between the group....
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Posted by admin on Aug 31, 2022 in |
The major pathogenic mechanisms of diabetes are chronic hyperglycemia and glucotoxicity. Excess production of reactive oxygen species due to hyperglycemia results in oxidative stress and changes in mitochondrial energy metabolism promote β cell dysfunction, eventually leading to apoptosis and the development of diabetic complications. Although several oral antihyperglycemic agents are available, their adverse effect profile affects their prolonged use. Medicinal plants, having a low toxicity profile, are being looked at as alternatives for diabetes treatment. The present study was thus planned to elucidate the mechanisms of action of 5 medicinal plantsviz. Azadirachta indica, Momordica charantia, Gymnema sylvestre, Syzygium cumini, and Trigonella foenum graecum selected on the basis of Ayurveda in diabetes using RINm5F cells. The effects of these plants on Streptozotocin (STZ) induced oxidative stress was assessed using variables like lipid peroxidation in terms of malondialdehyde (MDA) release, modulation of apoptosis, cell cycle analysis using flowcytometry, and insulin release using commercially available rat insulin Elisa kits. All the plant extracts in the presence of STZ inhibited the release of...
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Posted by admin on Aug 31, 2022 in |
Antimicrobial activity of stem bark of Mangifera indica was determined using the disk diffusion method to determine the susceptibility or resistivity of Staphylococcus species to the plant extract. Ethanol extract showed the highest inhibition zone diameter of 34mm, while the aqueous extract showed a zone diameter of 23 mm. The ethanol proved to be a better solvent, and the Staphylococcus species was found susceptible to the ethanolic extracts. The stem barks extracts can be used to develop new antimicrobial compounds. Survey results revealed a need to increase awareness to limit the overuse of harmful chemical cosmetics as skin care products and augmentation in the use of organic extract for skincare products among...
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Posted by admin on Aug 31, 2022 in |
Background: Artificial sweeteners are well-known today because of their high sweetness property with low or no caloric intake. However, consuming artificial sweeteners interferes with normal physiological processes within our bodies. Objectives: The study investigates biochemical changes in blood glucose homeostasis and hematocrit parameters during and after terminating intakes of aspartame and sucralose in male albino rats. Methods: the experimental design included 54 male albino rats in five groups, twelve rats for each group, except the control group contained six rats. 2 and 4 g/kg of sucralose and 0.8 and 1.6g/kg of aspartame were given orally every day for 12 weeks. Aspartame and sucralose were omitted for a further six weeks. Fasting blood glucose, insulin, insulin resistance (HOMA-IR), (HbA1c), and CBC were measured. Results: HOMA-IR increased in rats supplemented by high doses of either sweetener and HbA1c significantly increased in rats fed on low and high concentrations of Sweetal® (6.43 and 6.85 mmol/mol, respectively). Conclusion: Although terminating artificial sweeteners intake decreases blood glucose gradually, artificial sweeteners intake is still a...
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Posted by admin on Aug 31, 2022 in |
Background: Migraine is one of the major causes of disability affecting the productivity, physical, psychological and social well-being of patients. To conduct a systematic review and network meta-analysis (NMA) of randomized trials investigating the effect of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) on productivity and physical functioning of adults migraineurs. Methods: Databases were searched from inception to May 2021. Work productivity and physical functioning were evaluated using change in patient-reported Work Productivity and Activity Impairment (WPAI) and Migraine Physical Function Impact Diary (MPFID) scores. The NMA was conducted with fixed-effects model in Bayesian framework. Results: Overall, 26 studies (4,393 migraineurs in five randomized trials) were included with a treatment course of at least 12 weeks. With limited treatments in network formed, subcutaneous injections of fremanezumab 675+225+225 mg QM and 225+225+225 QM were more effective in reducing loss of overall work productivity, activity impairment, and impairment experienced while at work in chronic and episodic migraine, respectively, with the higher median difference in WPAI scores from baseline compared to a...
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