Posted by admin on Nov 30, 2022 in |
Purpose: The goal of this study was to develop taste-masked orally disintegrating tablets of the bitter-tasting levocetirizine dihydrochloride (LCDH) to improve the accessibility and adherence of pediatric, elderly, non-cooperative and paraplegic patients. Methods: In the present study, orally disintegrating Levocetirizine dihydrochloride tablets were formulated by direct compression. Taste masking was achieved using a pH-independent polymeric dispersion of Surelease E-7-19040 in combination with Opadry YS-1-19025-A in different ratios. In-vivo taste evaluation was done to see if the tablets produced utilizing the direct compression approach were successfully disguised. Results: The present study investigated uncoated and coated drug substances and prepared tablets of coated LCDH for flow as well as compression behaviour, Fourier Transform Infrared absorption spectra, Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy and in-vitro dissolution and disintegration properties. Conclusion: Using a combination of two polymeric dispersions “Sure lease E-1-19040” and “Opadry” coating for the delivery of LCDH, it was shown that a taste-masking evaluation could be performed to identify effective polymer-carriers for the...
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Posted by admin on Nov 30, 2022 in |
Introduction: SSI (Surgical site infection) is the dreaded complication following orthopaedic surgery. The main source of surgical site infection is the patient’s own skin flora. So skin preparation plays a major role in preventing the SSI. This study aims to compare povidone-iodine and 2% chlorohexidine alcohol in pre-operative skin preparation in elective orthopedic surgery and followed uo for 4 weeks for and postop SSI. Methods:This was a prospective study of 30 patients who underwent elective orthopaedic procedures between October 2021 to November 2021 with a follow-up duration of 4 weeks. A group of 30 patients of both sexes, different age groups with associated co-morbidities were included in our study. Results: They were divided into 2 groups of 15. Group-1 consisted of 9 males and 6 females; their mean age was 51, of which 9 had associated co-morbidities. Group-2 consisted of 8 males and 7 females. There were statistical differences (p<0.05) between co-morbidites in both groups and no statistical difference in risk factors between the two groups in terms of...
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Posted by admin on Nov 30, 2022 in |
Background: Hoffa fracture management is almost always surgical since it involves the intraarticular part of the femur. It can be managed either with cannulated cancellous screw alone or with the addition of a buttress plate. The study aimed to evaluate and compare the functional outcome of fracture fixation between the CC screw &CC screw with a buttress plate. Method: This was a prospective study of 30 patients with Hoffa fracture conducted between January 2020 to December 2021. Patients were allotted into 2 groups. Group A was treated with CC screw fixation, Group B was treated with CC screw + buttress plate. Post-operatively, follow-up was done for 1 year. Results: There were 14 males and 16 females in our study with both sides equally injured. The mean age of patients was 36.1 ranging from 23 to 52 years. RTA was the most common mode of injury. The average blood loss during group A was 117 ml and for group, B was 182.1 ml which is statistically significant. The average postoperative...
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Posted by admin on Nov 30, 2022 in |
A simple, fast, inexpensive, and reliable UV spectrometric method was developed and validated to quantify Econazole Nitrate incorporated in topical gel in the form of co-crystal. This article presents the development and validation of different methods for quantification of Econazole nitrate co-crystal loaded in the topical gel as per ICH [Q2(R1)] guidelines. In method-A, the standard and sample solutions were prepared in Methanol; in Method-B the solution was prepared in a mixture of Methanol: phosphate buffer pH7.4. Based on analysis of UV spectrum, different wavelengths were selected for analysis of drug by two methods, 220 nm was selected for method A whereas 265 nm was selected for method B. The linearity of drug was obtained in the concentration range 2-10 μg/mL (R2= 0.9988) in method-A and concentration range 20-100 μg/mL (R2= 0.9984) in Method-B. The accuracy of both method was checked by calculating % recovery at 80percent, 100percent and 120percent. The % recovery by both methods was obtained to be in the range of 80-90percent. The less values of...
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Posted by admin on Nov 30, 2022 in |
Introduction: Coumarins are secondary metabolites widely spread in nature. Due to their broad pharmacological activities, many natural and synthetic coumarins and more complex related derivatives are of interest. The coumarin is extremely variable in structure due to the various types of substitutions in their basic structure, influencing their biological activity. Metal complexes of coumarins obtained revealed higher biological activity than their ligand. Metal complexes play a vital role as chemotherapeutic agents. Methods: 7-amino-4-methylcoumarin refluxed with substituted aromatic aldehydes in absolute alcohol in presence of acetic anhydride and was washed with cold water to give Schiff bases of 7-amino-4-methylcoumarin (4a-4j). Further, the metal complexes of coumarin Schiff base (5a-5j) were synthesized by dissolving both Schiff base of 7-amino-4-methylcoumarin and metal sulphates in methanol and are stirred at 250C with dropwise addition of a dil. ammonia. Result and Conclusion: Screening the copper metal complexes against breast cancer cell line (MDA MB 231) with standard Paclitaxel using MTT assay method. The synthesized metal complexes show anticancer activity in a concentration-dependent manner. The...
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