Posted by admin on Jan 31, 2023 in |
Citrus sinensis are treasuries to deliver novel drugs and a significant aromatic medicinal plant reported to possess a broad spectrum of medicinal uses. The compounds present in these plants can deliver the potential therapeutic drug. A free web tool, SWISS ADME predictor, was used to evaluate the pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of phytoconstituents under investigation. The in-silico study has been deployed to screen the phytochemical components D-limonene, α-pinene, and β-pinene in Citrus sinensis. Against the protein target of RNA-dependent RNA-polymerase and Spike receptor binding domain with the aid of AutoDockVina software. All calculations for protein-fixed ligand-flexible docking were done using the Lamarckian Genetic Algorithm (LGA) method and analyzed using BIOVIA Discovery Studio 2016.13. The Phytoconstituents also showed good hydrophilic-lipophilic balance, good bioavailability, and decent GI absorption. The results obtained after docking showed a good binding affinity and implicated the active phytoconstituents for drug discovery and...
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Posted by admin on Jan 31, 2023 in |
Nanoemulsions, also mentioned as submicron emulsions, ultrafine emulsions and miniemulsions, are submicron-sized colloidal particulate systems considered as thermodynamically and kinetically stable isotropic dispersions; they contain two liquids like water and oil (immiscible), stabilized by an interfacial film consisting of a suitable surfactant and co-surfactant to form a single phase. In this research, lawsone nanoemulsion was developed by using Neem oil, tween 80 and ethanol. The formulation optimization was done by designing a ternary phase diagram followed by water dilution method. We developed 6 formulations (F1-F6) with different concentrations of oil and surfactant but drug concentrations are the same in all developed formulations. Developed formulations are evaluated for different parameters like pH, solubility, drug content, viscosity, transparency, size of globules and stability study, etc., and found to be appropriate in all tests. Since, oil/water Nanoemulsion had greater density than water/oil systems, the stiffness values increased significantly whenever the water content increases or when the system switched to oil/water type. Antimicrobial screening of the drugs and formulations were also screened against...
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Posted by admin on Jan 18, 2023 in |
Phytosomes is vesicular drug delivery system in which phytoconstituents of herb extract surround and are bound by lipid. Hexadecanoic acid is the phytoconstituents of Nigella sativa oil. Hexadecanoic acid is hydrophobic and possesses less solubility and permeability. The study aims to formulate, optimize, and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity hexadecanoic acid loaded phytosomes were prepared using Thin film hydration method and were optimized using factorial design (32) using Design-expert® software (Version 7.0.0, Stat-Ease Inc., Minneapolis, USA) different formulations were prepared. Two different independent variables were used, which include: Amount of Soya lecithin (X1), amount of cholesterol (X2) and the responses are particles size determination (Y1), and entrapment efficiency (Y2). The optimized formulation of hexadecanoic acid phytosomes was incorporated into a Carbapol 934 gel base and 1.5% of hexadecanoic acid phytosomal gel was prepared which was evaluated for drug content, pH, Spreadability, viscosity and in-vitro drug release. The prepared hexadecanoic acid phytosomes had a maximize EE% was found to be (72.23%), particle size was found to...
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Posted by admin on Dec 31, 2022 in |
A facile, highly efficient, simple, and convenient method for synthesizing 2, 4, 5-trisubstituted imidazole derivatives from the condensation of various substituted benzaldehyde, benzil, and ammonium acetate by using a catalytic amount of PEG-SOCl in the presence of water at room temperature or under microwave irradiation. PEG-SOCl is an effective heterogeneous catalyst and easy to separate. We have investigated that PEG-SOCl catalytic system was excellent recycled and reused three times without any loss of catalytic activity. PEG-SOCl act as a green catalyst, low-cost, non-volatile, non-hazardous, environmental friendly catalyst, and water is a green solvent reaction carried out at room temperature or under microwave radiation method shows greater advantages because it has contributed in the green chemistry aspects. The prepared catalyst was analyzed by analytical methods such as infrared spectrum (IR), X-Ray diffraction pattern (XRD), thermo-gravimetric analysis (TGA), and BET surface analysis. Spectroscopic techniques identified the synthesized pure product (1j), including infra-red (IR) spectrum, 1H and 13C NMR spectrum and Mass (LC-MS)...
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Posted by admin on Dec 31, 2022 in |
Rapidly Dissolving Drug Delivery Systems have become interested in the pharmaceutical industry as frameworks that provide quick onset of action with enhanced dissolution characteristics. Risperidone, a poorly water-soluble drug, is a second-generation antipsychotic of the benzisoxazole derivatives used in treating schizophrenia and other mood disorders. The present research work aimed to fabricate fast dissolving buccal film of Risperidone solid dispersion, using a quality by design (QbD) approach. Formulation with the drug: polymer ratio of 1:1 prepared by a solvent evaporation method using polyethylene glycol 400 showed the highest drug release. QbD was applied to the films prepared by the solvent casting method. Preliminary screening studies, along with initial risk assessment and the use of Box- Behnken design, allowed the selection of HPMC E5, PEG 400, and Croscarmellose sodium as critical material attributes for film formulation and as independent variables. In contrast, folding endurance, disintegration time, and tensile strength were taken as response variables. The films were evaluated based on in-vitro percent drug dissolution, disintegration time, percent elongation, tensile strength,...
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