Posted by admin on Oct 31, 2022 in |
Background: Acute respiratory infections are the most important cause of mortality and morbidity among under-five children in developed and developing countries in the world. There is lack of awareness/ knowledge among parents regarding antibiotic use in children for minor respiratory ailments. Hence, the present study was undertaken. Methods and Methodology: After taking institutional ethical clearance a Descriptive study on 100 mothers of under-five children attending Urban Health Training Centre of KIMS, Bangalore, is enrolled by convenience sampling. Using pre-structured and pre-tested questionnaire proforma, socio-demographic details, a few questions related to acute respiratory infections were collected. After the pre-test, health education was given to the urban health training center participants using flip charts. Followed by 2 weeks of health education, the same questionnaire was given to the subjects, and details were collected. Descriptive statistics and SPSS V20 were used for statistical analysis. Results: Pre and post-test knowledge and attitude were analyzed using wilxcon sign rank test, which showed the effect of health education was found to be statistically significant with...
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Posted by admin on Oct 31, 2022 in |
N. nucifera, often recognized as lotus, is an aquatic plant. Extracts of various solvents have shown therapeutic potential against many diseases. This research focused on screening preliminary qualitative phytochemicals and investigating the seed’s antioxidant activity. Primary and secondary metabolites were discovered in a hydroethanolic fraction of different extracts of lotus seeds. The extractive value, total ash (3.56±0.36) water-soluble (0.86±0.68), and acid insoluble ash value (2.09±0.88) were determined. The solvents benzene, chloroform, ethyl acetate, n-butanol, and aqueous were used as extracts. TPC and TFC content of ethyl acetate extract of seeds were found to be 366.6±10.77 (mg GAE/ g-1 dry weight) and 344.4±3.71 (mg RE/ g-1 dry weight), respectively. The ethyl acetate fraction of the seed extract showed the lowest value determining the highest free radical scavenging activity (105.30 ± 12.06µg/ml) in DPPH and FRAP (142.2± 0.0509 mgAA gm-1). The values were found to be close as compared to the standard (56.40±23.63µg/ml).The results support high antioxidant content in the seed extract of N. nucifera. FTIR and GCMS did the characterization...
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Posted by admin on Oct 31, 2022 in |
Orange (Citrus sinensis), Kinnow (Citrus reticuleta), and Mosambi (Citrus limetta) methanolic, the aqueous extract showed the inhibitory activity on α-amylase and α-glucosidase assay where methanolic, acetone and aqueous extract of these fruit peels exhibited the anti-hypertensive activities. The results showed that the methanol and aqueous extract of Orange, Kinnow, and Mosambi peels inhibited α-amylase and α-glucosidase activities. However, Orange peels (IC50 = 18.4 and 9.43 µg/mL) and Kinnow peels (IC50 = 12.6 and 6.09 µg/mL) exhibited higher capacity to inhibit α-amylase activity compared to Mosambi peels (IC50 = 11.6 and 6.54 µg/mL) and Orange peels (IC50=12.5 and 8.67 µg/mL) methanol and aqueous extract exhibited higher inhibitory effects on α-glucosidase activity compared to Kin now (IC50= 9.78 and 7.65 µg/mL) and Mosambi peel (IC50=4.56 and 10.6 µg/mL).respectively. Similarly, methanol, acetone, and aqueous extract of Orange, Kin now and Mosambi inhibit the angiotensin-1-converting enzyme (ACE) activity. Moreover, methanol and acetone extract of Orange (IC50 =0.38 and 0.40 ug /mL) and Mosambi (IC50 = 0.44 and 0.46ug /mL) showed significant inhibitory capacity...
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Posted by admin on Oct 31, 2022 in |
A simple, novel, precise, and cost-effective reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated to simultaneously estimate ezetimibe and bempedoic acid in the marketed tablet dosage form. The chromatographic separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of Acetonitrile: water (60:40 v/v). The flow rate was 1.0 mL/min with detection at 225 nm using UV detector. The retention time for bempedoic acid was 4.7 min, and for ezetimibe 5.7 min. Ezetimibe showed a linear response in the concentration range of 20-60 µg/mL. Bempedoic acid showed a linear response in 180-540 µg/mL concentration range. The correlation coefficient (‘r²’ value) for ezetimibe and bempedoic acid was 0.9982 and 0.9998, respectively. The results of analysis have been validated as per different validation parameters. The percentage recoveries obtained for ezetimibe and bempedoic acid range from...
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Posted by admin on Oct 31, 2022 in |
Streblus asper Lour is traditionally used for anti-diarrheal and anthelmintic activity. The present study aims to prove the antidepressant activity in a different extract of leaves of S. asper Lin animal models. The extracts of Sterblus asper L. significantly reduced the immobility time in the forced swimming test (FST), notable at 400 mg/kg when compared with the control group. The immobility time in the tail suspension test (TST) using mice markedly reduced after acute 14 days of treatment with Despiramine Hydrochloride (30 mg/kg). Administration of extracts of Streblus asper L. at dosages of 100, 200, and 400 mg/kg significantly reduced the immobility time. The extracts of Streblus asper L. (100mg/kg) shown that the same locomotion effect as the control group. However, 200 mg/kg and 400 mg/kg doses of Streblus asper L. significantly increase locomotion, rearing, and defecation. The result obtained from the forced swimming test (FST), tail suspension test (TST), and measurement of locomotor activity test (MLAT) indicate that the ethanolic extract of the leaves of S. asper L....
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